Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"tyrosine kinase signaling"”.
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REGULATION OF C-MET RECEPTOR TYROSINE KINASE SIGNALING BY ANGIOTENSIN-(1-7) IN TRIPLE NEGATIVE BREAST CANCER
Breast cancer remains a devastating disease, negatively impacting the lives of many women worldwide. In the United States, 40,450 women succumbed to breast cancer in 2015, with an estimated 247,000 new cases being diagnosed in 2016. Approximately 15% of all breast cancer cases will be classified as …
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Transcriptional Regulation of Profilin Is Required For Drosophila Larval Wound Closure
… In Drosophila larvae, wound closure requires two signaling pathways (the Jun N-terminal kinase (JNK) pathway and the Pvr receptor tyrosine kinase signaling pathway) and regulation of the actin cytoskeleton. In this and other systems, it remains unclear how the signaling pathways that initiate …
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Activation of Ca<sup>2+</sup>-activated K<sup>+</sup> Channels and Cell Migration by Hepatocyte Growth Factor/Scatter Factor in Madin-Darby Canine Kidney Cells.
… of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on activation of a charybdotoxin (ChTX)-sensitive, volume-activated …
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The role of adaptor proteins Crk and CrkL in lens development
Cell shape changes and signaling pathways are essential for the development and function of the lens. During lens development proliferating epithelial cells will migrate down to the equator of the lens, differentiate into lens fiber cells, and begin to elongate along the lens capsule. The …
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Phospho-regulation and metastatic potential of Murine Double Minute 2
… while maintaining p53 protein levels. While the signaling events that regulate Mdm2 E3 ubiquitin ligase activity have been extensively studied, what activates the neddylating activity of Mdm2 has remained elusive. My investigations have centered on understanding whether tyrosine kinase signaling …
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Function, expression and evolution of the *Src family kinases in Caenorhabditis elegans
… of a family of membrane-associated protein tyrosine kinases involved in cell signaling pathways that control cell growth, development, and differentiation. Activation of Src by mutation or overexpression has been implicated in a range of cancers, particularly breast and colon cancer. …
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Predicting Genetic Interactions Using Functional Interaction Networks
… clinically relevant processes such as receptor tyrosine kinase signaling and DNA damage response pathways and were prioritized for screening using a multiplex CRISPR platform.</p> <p>Collectively, this work presents brings together strategies in data processing, network modeling, and synthetic …
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Analysis of the organization and dynamics of proteins in cell membranes
… are critical to signal transduction. Problems in signaling networks are important in understanding many diseases including cancer, allergy and asthma, so there is great interest in understanding these changes. Biologists in the Spatiotemporal Modeling of Cell Signaling Center (STMC) have generated …
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Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
<p>The Abl family of protein tyrosine kinases regulates diverse cellular processes by coordinating cytoskeletal rearrangements. Recent data indicate that pharmacological inhibition of Abl kinases reduces inflammation in preclinical models and in the clinic. While a previous role for Abl kinases in …