Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"tyrosine kinase receptor"”.
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Truncated Tyrosine Kinase Receptor B (TrkB.T1) plays a role in susceptibility to chronic stress
Brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) have been implicated in depressive/anxiety disorders. The efficacy of antidepressants may be related to BDNF-TrkB signaling fueling neuroplastic changes. TrkB.T1 might have novel signaling effects that may be relevant for dealing …
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Engineering functional recombinant proteins based on antibody domains and fragments of C. botulinum neurotoxin
… selected scFv binds to CD117 that is a membrane tyrosine kinase receptor present on the surface of various tumour cells. The variable part of chains shows great variability in amino acid sequence among the chains. The unique sequence of amino acid residues for variable fragments leads to the …
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Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation
… in DA release is not mediated by DA D3 autoreceptors. Meanwhile, chronic toluene exposure attenuated DA release only in the nucleus accumbens (NAc). Repeated toluene exposure also increased extracellular DA levels in the NAc, which is typical of addictive drugs. However, repeated toluene …
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Regulation of flt3 gene expression in haematopoietic and leukaemic stem cells
The interaction between the tyrosine kinase receptor Flt3 and its ligand leads to signalling during the commitment of haematopoietic stem cells (HSCs). Constitutive activation of the Flt3/FL pathway is a key factor in enhanced survival and expansion in acute myeloid leukaemia (AML). Although there …
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Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
Internal tandem duplications in the fms-like tyrosine kinase receptor (FLT3-ITDs) cause constitutive activation of the receptor and confer a poor prognosis in acute myeloid leukemia (AML). We hypothesized that Shp2 interacts with FLT3-ITD via protein complexes at tyrosine (Y) 768, 955, and/or 969 …
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Novel Immune-Regulatory Mechanisms in a Mouse Model of Traumatic Brain Injury
… TBI as well as discovering a novel role for the tyrosine kinase receptor EphA4 in the peripheral-derived immune response to brain trauma. Previous work has demonstrated significant differences in recovery from TBI in young vs adult animals, and some studies have indicated that the immune response …
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Role And Regulation Of ESCRT-III In Multivesiculr Body Biogenesis
… body: MVB) biogenesis is essential for receptor downregulation, viral budding and cytokinesis. ESCRT-III is a large polymer built from related ESCRT-III proteins that is thought to help generate intralumenal vesicles: ILVs) within the MVB. How ESCRT-III functions is poorly understood. …
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Role Of d16HER2 Splice Variant In Breast Cancer Stem Cells
The transmembrane tyrosine kinase receptor HER2 is overexpressed in about 20% of human breast cancers (BCs). Evidence suggests that the co-existence of the full-length/wild-type HER2 oncoprotein (WTHER2) with its altered isoforms increases the heterogeneity of HER2 overexpressing (HER2+) disease …
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Wnt-5a signaling in breast cancer metastasis
… breast cancer cells. In addition, the Wnt-5a coreceptor Ror2 was found to be involved in regulation of breast cancer cell migration and to associate with DDR1, a tyrosine kinase receptor that participates in Wnt-5a signaling. These results further emphasize the importance of Wnt-5a in breast …
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Identifying and Targeting Molecular Deregulations In Uterine Leiomyosarcoma: A Role For Mtor Inhibition-Based Combination Therapies
… in ULMS, examined the possible contribution of tyrosine kinase receptor deregulation promoting mTOR activation, and unraveled a role for pS6RP and p4EBP1 as molecular disease prognosticators. The significance of mTOR activation in ULMS and its potential as a therapeutic target were further …
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Identification of Markers to Predict Benefit from Trastuzumab Treatment
… characterised by high expression of the NKG2D receptor. Enrichment of immune system- and tyrosine kinase receptor signaling-related pathways was found associated also with response to trastuzumab monotherapy in clinical samples, suggesting the possibility to treat HER2-addicted tumours with …
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Investigating the isoform-specific role of phosphoinositide 3- kinase p110delta
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that regulate a diverse array of biological functions in every cell type by generating lipid second messengers. The PI3K family is comprised of multiple isoforms that are divided into three main classes; class I, II and III. All class I …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… demonstrated that another cytokine, fms-like tyrosine kinase receptor 3 (FLT3) ligand (FL), is an important regulator of B cell progenitors but has a redundant role in steady state maintenance of mature B cells, we here demonstrate that FL plays a crucial role in the regeneration of not only B …
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The role of cancer stem cells in osteosarcoma
… enzyme aldehyde dehydrogenase (ALDH) and tyrosine kinase receptor CD117 were found to be heterogeneously expressed amongst the cell lines. All cell lines when plated at low density could recapitulate the colony hierarchies based on variation in colony morphology (holoclones, meroclones and …
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Interactions between the haematopoietic stem cell and the myeloid microenvironment in aplastic anaemia
… belonging to the G protein super-family and the tyrosine kinase group in dose response studies. Light density cells from patients with treated aplasia contained significantly fewer CD 34+ cells than those present in the control suspensions (mean 0.65%, SD 0.35% vs 1.62%, SD 1.4%; p= 0.002). …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… utilized the combination of α and β adrenergic receptor complex, while CORT signaled through glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) to reactivate HSV in the neurons. NTFs are tissue-target derived growth factors required for neuronal protection and survival. …
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Defining The Role of Egfr Acetylation In Cellular Processes: Clinical Implications
<p> Epidermal growth factor receptor (EGFR) is a cell membrane tyrosine kinase receptor and plays a pivotal role in regulating cell growth, differentiation, cell cycle, and tumorigenesis. Deregulation of EGFR causes many diseases including cancers. Intensive investigation of EGFR alteration in …
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Functional miRNA-based Phenotypic Screening as a tool to delineate HIV-host interactions and facilitate Novel Drug Discovery
… including host DNA damage repair, cell cycle and tyrosine kinase receptor-mediated signalling. Experimental validation confirmed that HIV replication induced an aberrant cell survival phenotype in response to chemically induced DNA damage but this effect was reversed when DNA damage was induced …
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Molecular Mechanisms Regulating Neonatal Oocyte Survival and Primordial Follicle Formation in the Mouse Ovary
… and cyst breakdown in the neonatal ovary. The tyrosine kinase receptor, KIT, and its ligand, KITL, have been implicated in oocyte survival and follicle development in both fetal and adult ovaries but have not been well studied at the perinatal time point. To elucidate the functional role of KIT …
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Investigation of the effect of a probiotic-supplemented diet on the haemocyte proteome of the abalone Haliotis midae
… other. It was also found that the neurotrophic tyrosine kinase receptor was the central molecule within the interaction network, suggesting that this protein may play a crucial role within the protein interaction network that contains all the differentially expressed proteins. Biochemical …
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