Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"tyrosine kinase inhibitor"”.
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… of Linifanib (ABT-869), a multi-receptor tyrosine kinase inhibitor of VEGF and platelet derived growth factor (PDGF) receptor families, on radio-sensitization of HNSCC. The results show that Linifanib (ABT-869) can induce an antitumor effect and radio-sensitize HNSCC cells via inhibition …
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Prognostic markers associated with tyrosine kinase inhibitor treatment response and maintenance of treatment free remission in chronic myeloid leukaemia
… improved with the introduction of highly active tyrosine kinase inhibitors (TKIs). However, treatment responses are highly heterogeneous. The aim of this thesis is to identify prognostic markers that may help individualise treatment and optimise outcome by stratifying patients into risk groups. …
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Genistein-Induced Potentiation Effect on Glucose-Stimulated Insulin Secretion (GSIS) in INS-1 β-cells
… isolated from soy bean seed and having tyrosin kinase inhibition activity, had a potentiation effect on GSIS (glucose-stimulated insulin secretion) in pancreatic INS-1 beta cells. Although the potentiation effect was glucose-dependent, the signal involved in potentiation effect were not …
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An optical proteomic profile of the HER2 family in breast tumours and the effect of exposure to tyrosine kinase inhibitors
… of the effects of HER2-targeted therapy with the tyrosine kinase inhibitor (TKI) lapatinib, in vitro, and elucidation of the ensuing conformational changes may help understand the molecular activity of lapatinib and elucidate mechanisms of resistance. Clinical translation of this knowledge may …
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Development and application of novel analytical methods for molecularly targeted cancer therapeutics
… were developed for the quantification of 1) tyrosine kinase inhibitor anti-cancer drugs to examine the interaction of these agents with drug resistance mechanisms, and 2) the multiple myeloma drug thalidomide as a pilot study to identify potential correlations between serum drug levels and …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
… target tumors in a specific way. Small molecule inhibitors represent an attractive approach to pursue this. However, the absence of molecular structures for most of the miRNAs makes it very difficult to predict which inhibitors can bind to them. Herein we designed a strategy to screen for small …
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The Role of Type I Insulin-Like Growth Factor Receptor Signaling In Breast Cancer Brain Metastasis
… with picropodophyllin, an IGF-IR-specific tyrosine kinase inhibitor. Together, our data suggest that the IGF-IR is an important mediator of brain metastasis and its ablation delays the onset of brain metastases in our model system.</p>
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The unfolded protein response and HLA-B27 misfolding: implications for ankylosing spondylitis
… signals, since co-administration of the tyrosine kinase inhibitor genistein leads to activation of XBP1. Furthermore, we show that genistein can inhibit UPR induction of BiP in response to a range of ER stresses indicating that the cancer drug genistein can inhibit or activate the UPR …
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Understanding the Molecular Level Interactions of Cancer Inhibitor Imatinib with Human Fibroblast Growth Factor-1
… a 2-phenyl amino pyrimidine derivative is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to the intracellular pocket located within tyrosine kinases and inhibit the downstream cell proliferation events, but the exact molecular mechanism is still elusive. In this …
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Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
… know that cytokines relay their signals through tyrosine kinase and we have previously demonstrated that histamine regulated the levels of various cytokines which phosphorylate STAT1. We were therefore interested in finding out if the effect of histamine on STAT1 phosphorylation is mediated …
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Growth regulation in the protozoan parasite Trypanosoma brucei: Evidence of tyrosine-specific protein kinase activity
Phosphorylation of proteins at tyrosine is an important mechanism for regulating cell growth and proliferation in metazoan organisms. This phosphorylation is conducted by a tyrosine-specific protein kinase. The activation of tyrosine kinases is an important step in transducing extracellular signals …
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Protein kinase C modulates mitogenic signalling by epidermal growth factor in T51B rat liver cells.
… epidermal growth factor (EGF) and the protein kinase C (PKC) signal-transduction pathways. T51B cells can be made proliferatively quiescent upon prolonged serum deprivation, which results in their growth-arrest at the G1 phase of the cell cycle. Addition of EGF (1.5$\eta$M) or, re-addition of …
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Flourescent Biosensor-Based, Cdc42 Activity Imaging For Understanding the Regulation of Epidermal Growth Receptor (EGFR) Signalling in Head and Neck Cancer
… in Squamous Carcinoma Cell Lines after EGFR tyrosine kinase inhibitor (TKI) treatment, using the FRET biosensor Raichu-Cdc42. I have demonstrated that conversely, Raichu-Cdc42, and consequently endogenous Cdc42 activity increases significantly following EGFR TKI treatment. Further …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
… growth factor-A (VEGF-A), VEGF-C and AZD2171, a tyrosine kinase inhibitor of the VEGF receptors, were tested as radiation sensitizers and protectors. Our results indicate that VEGF-A and VEGF-C are radiosensitizers while AZD2171 did not modulate the radioresponse. In vivo, normal lymphatics were …
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Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer
… was to assess the potential role of selected inhibitors in TNBC, including the small molecule tyrosine kinases inhibitors of EGFR gefitinib and erlotinib, the monoclonal antibody against EGFR cetuximab, and the multi-target tyrosine kinase inhibitor dasatinib. Significantly higher EGFR …
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Characterisation and modulation of drug resistance in lung cancer cell lines
… cells. Lapatinib, a growth factor receptor tyrosine kinase inhibitor synergised with P-gp substrate cytotoxics in P-gp over-expressing resistant cells. However, lapatinib treatment, at clinically relevant concentrations, also increased levels of the P-gp drug transporter in a dose-responsive …
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Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells
… carcinomas. Lapatinib is an ErbB1 and ErbB2 tyrosine kinase inhibitor that has been shown to have anti-proliferative effects in breast and lung cancer cells. Cells treated with Lapatinib undergo G1 phase arrest, followed by apoptosis. Lapatinib has been approved for clinical use, though …
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Application of Informatics Tools to Facilitate the Practice of Precision Medicine with Genomic Testing and Clinical Data
… lung cancer patients receiving immune checkpoint inhibitor (ICI) therapy. Through multivariate statistical models and vi survival analyses, we demonstrated the impact of various clinical and biomolecular variables on patient survival. Our results showed patients experiencing immune related adverse …
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