Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"tyrosine kinase activity"”.
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Molecular determinants regulating Bruton’s tyrosine kinase activity and their mechanism: a combined computational and experimental approach
… the unique sequence elements that regulate the activity of a protein tyrosine kinase called Bruton’s tyrosine kinase or Btk. Btk is a member of the immune signaling pathway in B-cells and is required for B-cells maturation and function.</p> <p>Lack of a three-dimensional structure of full-length …
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Molecular Cloning of Avian Sarcoma Virus CT10 and Characterization of its Protein Product
… regulatory region found in the nonreceptor tyrosine kinases, a phosphoinositide-specific phospholipase C, and the ras GTPase activator protein; no homology was found to any known catalytic domain. Potential roles for the homologous domains, termed SH2 and SH3, in normal signal transduction …
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A therapeutic approach to chronic myeloid leukaemia using short hairpin RNA molecules
… 9 and 22, where the ABL gene on chromosome 9, a tyrosine kinase, is translocated to the BCR gene region on chromosome 22 giving rise to an abnormal BCR/ABL fusion gene. The resultant <br/>fusion gene has an abnormally upregulated tyrosine kinase activity that results in an increase in the …
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Identification of novel components in fibroblast growth factor signalling
… and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling proteins, formation of multiprotein signalling complexes and activation of downstream cascades. The goal of this project was to identify novel FGFR1 interacting proteins. The …
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A Role for RAS in V-CRK Transformation
… oncogene product, while possessing no intrinsic tyrosine kinase activity, causes an elevation in levels of cellular phosphotyrosine as it transforms chicken embryo fibroblasts (CEF). Because of this similarity to v-Src transformation and EGF receptor (EGFR) stimulation, signalling pathways that …
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Up-modulation of Hepatocyte Growth Factor/ c-Met Signaling by Protein Kinase C-g and its Mechanism
Protein kinase C (PKC) family is composed of 11 isoenzymes, and has been known to down-modulate the tyrosine kinase activity of c-Met, the receptor for hepaotcyte growth factor (HGF). However, specified roles by PKC isoenzymes on the regulation of HGF/c-Met signaling have never been addressed yet. …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
… Growth Factor Receptor (HGFR/cMet) is a receptor tyrosine kinase that is essential for multiple cell responses, including cell proliferation, survival, motility and branching morphogenesis. Normal HGFR signaling regulates embryonic development, organ regeneration and wound healing, whereas …
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Development of Tyrosine Kinase Peptide Biosensors and Methods for Detection
<p>New methods to monitor tyrosine kinase activity are critical for studying kinases in cell biology, drug discovery and the clinic. Peptide-based biosensors for detection of kinase activity utilitize a kinase specific artificial peptide substrate, which can report intercellular kinase activity …
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The role of integrin mediated adhesion and signaling during Xenopus retinal development
… integrin, talin, vinculin, paxillin and phosphotyrosine in retinal glial cell line XR1 and in the developing Xenopus retina. These proteins are colocalized at focal adhesions located at the termini of F-actin filaments in XR1 cells. These proteins display spatial and temporal expression …
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Novel Mechanisms of Kinase Independent Pro-Survival Functions of EGFR in Cancer
Tyrosine kinase activity of epithelial growth factor receptor (EGFR) plays an important role in regulating numerous signaling pathways in cancer. It is commonly overexpressed in various cancers. Several strategies for cancer therapy were developed to target the kinase function of EGFR. However, the …
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Visualizing Mast Cell Activation: Single Molecule Dynamics of Early Events in FceRI Signaling
… regulates its association with the intracellular tyrosine kinase Syk. Proper initiation of tyrosine kinase activity is absolutely necessary for all receptor dependent signaling, yet it is not completely understood how Syk function is regulated. In this work we use single molecule imaging to follow …
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The Oncogene of Avian Sarcoma Virus UR2 and its Cellular Homologue: Structure, Sequence and Expression
… P68<sup>gag-ros</sup>, which has an associated tyrosine kinase activity. To elucidate the basis of the functional conservation as well as differences between ros and other oncogenes, I sequenced the entire genome of UR2 and compared the predicted amino acid sequence of P68 with other members of …
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Studies on the Activity of the Long Terminal Repeat of Rous Sarcoma Virus in Animal Cells and in Yeast
… transformed 3Y1 was used to demonstrate that the tyrosine kinase activity of v-src can (a) substitute for the serum-requirement of the RSV LTR, (b) increase the level of transcripts initiated in the LTR even in the presence of serum, (c) exert its serum-sparing effect on the RSV LTR in the absence …
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Regulation of Expression of a Retroviral Transforming Gene and its Cellular Homolog
… is the transforming protein of FSV and that its kinase activity plays a crucial role in cell transformation by this virus. v-fps, the transforming gene of FSV is homologous to a cellular gene, c-fps, present in uninfected cells. We obtained a specific antiserum directed against the v-fps domain …