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Showing 1 to 13 of 13 for “"type IV secretion system"”.
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Characterization of The Agrobacterium Tumefaciens Virb2 Pilin of The Virb/D4 Type Iv Secretion System
… <em>tumefaciens</em> VirB/D4 type IV secretion system (T4SS) delivers oncogenic T-DNA and effector proteins to susceptible plant cells. This leads to the formation of tumors termed Crown Galls. The VirB/D4 T4SS is comprised of 12 subunits (VirB1 to VirB11 and VirD4), which …
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Interactions between an integrative and conjugative element and its bacterial host
Conjugative elements are mobile genetic elements that can transfer from a donor bacterium to a recipient via an element-encoded type IV secretion system. Integrative and conjugative elements (ICEs) are an abundant class of conjugative element. ICEs are typically integrated into the bacterial host …
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A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell
<p>"Helicobacter pylori is a spiral, gram-negative bacterium that colonizes the stomachs of approximately 50% of the World's population overall and is a major etiological agent of human gastric adenocarcinoma. Of infected individuals, only 10-15% develop severe gastric disease due to environmental …
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Elucidating the Secreted Bacterial Kinome
… have been acquired and revealed a remarkable diversity among protein families. This is especially apparent in pathogenic species where host and pathogen participate in an intense evolutionary arms race, and horizontal gene transfer is common. We have taken a bioinformatic approach to identify …
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Characterization of Helicobacter pylori sRNAs HPnc2525, HPnc2600, and HPnc2645
… pylori is a common microaerophilic gram-negative bacterium that infects approximately 50% of the human population. Although all H. pylori infections result in inflammation of the gastric epithelium, only 10-15% of infections are symptomatic and progress to severe gastric diseases such as …
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<em>Agrobacterium</em> Virb10 Contributions to Type Iv Substrate Secretion, T-Pilus Biogenesis, and Outer Membrane Pore Formation
The VirB/D4 type IV secretion system (T4SS) of <em>Agrobacterium tumefaciens</em> functions to transfer substrates to infected plant cells through assembly of a translocation channel and a surface structure termed a T-pilus. This thesis is focused on identifying contributions of VirB10 to substrate …
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Multiple virulence genes and other MRNA regulatory targets are differentially expressed in two Helicobacter pylori strains overexpressing small RNAs
… and cancer through the action of the cagPAI Type IV secretion system and its associated cytotoxin, CagA. Although the genetic regulation necessary for these and other virulence traits is complicated by a relative lack of regulatory proteins in H. pylori, its wealth of small RNAs (sRNAs) may …
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Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells
… a repertoire of high-affinity iron acquisition systems to facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy-harnessing cytoplasmic membrane protein, TonB, as well as specific outer membrane TonB-dependent transporters (TdTs). The overall goal of …
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Evasion Of Innate Immunity By The Pathogen Coxiella Burnetii
… is displayed by studies on the innate immune system, which is on a constant evolutionary arms race with invading microbes. In this dissertation, we explore the innate immune response to the bacterial pathogen Coxiella burnetii. This intracellular pathogen has an intimate association with host …
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Assessing Helicobacter pylori's HcpE and DsbK's Effects on Immunostimulation in Host Gastric Cells
… patient noncompliance, the search for an alternative treatment is essential. HcpE, a member of the Helicobacter cysteine-rich proteins (Hcps) family, contains the largest number of cysteine residues and is secreted extracellularly. Its structure is made of Sel-Like Repeats (SLR) motifs–stabilized …
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Structural Studies of the Receiver Domain of LytR from Staphylococcus Aureus and Interaction Studies of TraW and TrbC from the F Plasmid of Escherichia Coli
… concern to human health. Bacteria use various systems in combination or alone in response to environmental stressors and stimuli to adapt to changing conditions. Such systems include the two-component regulatory system (TCS) and the type IV secretion system (T4SS). Microbes use TCSs to regulate …
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Interplay between an integrative and conjugative element and its bacterial host
… Mobile genetic elements (MGEs) are the primary drivers of horizontal gene transfer, introducing large fragments of DNA. Often, MGEs contain cargo genes beneficial to the host, conferring new traits such as antibiotic resistances, pathogenicity, and metabolic capabilities. Though MGEs sometimes …
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Immunogenität translozierter Effektorproteine bei Infektionen mit Bartonella henselae
Bartonella henselae, ein gramnegatives Stäbchenbakterium, ist weltweit verbreitet und bekannt als der Erreger der Katzenkratzkrankheit, einer häufigen Differentialdiagnose einer Lymphadenopathie. Vor allem bei Immunsuppimierten kann Bartonella henselae auch die Bazilläre Angiomatose, die Peliosis …