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Showing 1 to 11 of 11 for “"type III collagen"”.
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Delayed Thrombus Resolution and Fibroproliferative Vascular Wound Healing From Deficiency of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility
… conferring a tissue deficiency of type III collagen. Cutaneous wounds heal poorly in these patients, and they are susceptible to spontaneous and catastrophic rupture of expansible hollow organs like the gut, uterus, and medium-sized to large arteries, which leads to premature death. …
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Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome
<p>Vascular type of Ehlers-Danlos Syndrome (vEDS) is an inherited cardiovascular disease affecting the middle to large sized arteries, with an incidence rate of 1/5000. vEDS patients also show a significant phenotype of easily bruised skin, indicating aberrant wound healing and injury repair …
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Collagen gene expression in human cancer
Type I collagen is the predominant collagen within the stroma and plays an important role in the processes of tumour cell invasion and metastasis during which the collagens within the stroma is degraded. Total RNA was extracted from different stages of breast cancer and adjacent normal tissue for …
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Proteolysis - induced changes in meat collagen during conditioning.
… of different quality. Perimysial and endomysial collagens were solubilized to a small extent during conditioning and residual insoluble collagens in both connective tissue domains were damaged by proteolytic processing. Yields of soluble perimysial material from unconditioned muscles were …
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
<p>Collagen fibrils are the primary molecular scaffold of all connective tissues and provide the essential support for cell migration and differentiation. Collagen fibrils represent one of the most complex molecular hierarchies: three polypeptide chains in Gly-Xaa-Yaa repeating amino acid …
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Comparative histology of human skin.
… to this study. (i) Two histological stains for collagen were compared against each other for the first time, namely Herovici's technique and picrosirius-polarization. (ii) Skin samples from embalmed cadaveric tissue from human cadavers were compared against samples taken from surgical patients. …
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The mechanism of collagenolysis : a substrate-centric view
Collagenolysis (collagen degradation) is a physiological process involved in normal tissue maintenance, but excessive collagenolysis has been associated with the progression of cancer metastasis, atherosclerosis, and other diseases. Despite considerable efforts to understand the steps involved, the …
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The Role of Type VIII Collagen in Fibrous Cap Formation and Progression of Atherosclerosis
Collagens play an integral role in the progression of atherosclerosis. Collagen synthesis and remodelling influence inflammation, smooth muscle cell (SMC) proliferation and migration, and properties such as plaque tensile strength and mechanical stability. Type VIII collagen is expressed at low …
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The role of unfolded states in collagen degradation
Excessive collagen degradation (collagenolysis) has been implicated in a series of diseases such as tumor metastasis, atherosclerosis and arthritis. There are still several unresolved questions about the mechanism of collagenolysis. First, the prototypical structure of the collagen triple helix …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
… of all five dopamine receptors in both wild type (WT) mouse heart tissue and LV cardiac fibroblasts. Then, the expression and relationship between excitatory dopamine receptor 1 (D1R) and inhibitory dopamine receptor 3 (D3R) was examined through a dopamine receptor 3 global knock out (D3KO) …
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An investigation into the anatomical and proteomic properties of the anterolateral ligament (all)
… matrix (ECM) composition, including type I collagen, type III collagen, decorin, biglycan, fibronectin, and tenascin-C-proteins characteristic of load-bearing ligaments. The FCL showed higher collagen abundance, and the ALL demonstrated high levels of decorin (20-22). In conclusion, …