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Showing 1 to 2 of 2 for “"type III TGF-beta receptor"”.
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Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression
… among women. The transforming growth factor-beta (TGF-β) pathway is an important modulator of breast cancer progression, acting in a tumor suppressing fashion in early carcinogenesis but switching in a poorly understood fashion to a promoter of cancer progression in later stages. …
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Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
<p>The type III TGF-β receptor (TβRIII) is a TGF-β co-receptor that presents ligand to the type II TGF-β receptor to initiate signaling. TβRIII also undergoes ectodomain shedding to release a soluble form (sTβRIII) that can bind ligand, sequestering it away from cell surface receptors. We have …