Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 103 for “"type I interferon"”.
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The role of type I interferon in chronic lymphocytic leukemia
Type I interferon (IFN) has pleotropic and context-dependent biological effects. IFN's involvement in viral infections is well known but its precise role in cancer remains elusive. The aims of this thesis were to study the role of IFN in chronic lymphocytic leukemia (CLL), the most common adult …
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Role of type I interferon in pulmonary inflammation and fibrosis
… Clinical studies have revealed elevated type I interferon (IFN-I) pathway activity in autoimmune patients with ILD compared to those without pulmonary involvement, with IFN-I levels positively correlating with disease severity, suggesting a potential pathogenic role in lung disease …
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
The type I interferon (IFN-α/β) family is a pleiotropic set of cytokines that play a role in regulating many biological functions, including suppressing viral replication and modulating adaptive immune functions. Although IFN-α/β has been extensively studied regarding the activation of interferon …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… adaptive immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and tumors. Although the importance of cDC1s is now well established, the mechanisms that regulate …
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Signal Transduction and Transcriptional Regulation in the Response to Type I Interferon
<p>The interaction of type I interferon (IFN) with a specific cell surface receptor elicits a number of physiological changes, including the attainment of a state in which viral replication and cellular proliferation is inhibited. The response to IFN is mediated by a group of IPN-induced proteins …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… of replication organelles, antagonism of interferon type I (IFN-I) responses, and NLRP3 inflammasome activation, a major factor of severe COVID-19. Here, I review the most recent published findings regarding the multiple roles of nsp6 in promoting SARS-CoV-2 replication and investigate …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… necrosis factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in cancer cells and in immune cells leads to the production of TNFα, which can then synergize with SMCs to kill cancer cells. The combined treatment of SMC and IFNα induces tumour regression in mice, and this …
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Contributions of type 17 immunity and type I interferon signaling to Salmonella-induced autoimmunity
… autoimmune sequelae remain unclear, type 17 and type I interferon (IFN) signaling play significant roles in the pathogenesis of many classical autoimmune diseases and bacterial infections. Previous research from our lab has shown that Salmonella biofilm-associated amyloid protein, …
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The role of the type-I interferon response in the aggregation of tau protein
… focusing on the current understanding of the type-I IFN response in AD and tauopathies. Finally, I present the hypotheses examined in this thesis. Chapter 2 describes the materials and methods used in this PhD thesis. Chapter 3 describes studies conducted in primary neural cultures and …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… or tumor progression following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to BCG standard of care. However, the mechanisms that mediate the IFN-I-stimulated …
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… regulation and more recently, modulation of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection …
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Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
Previous studies demonstrate that interferon alpha (IFN-α) promotes human T helper 1 memory development by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
… of SLE with an emphasis on ICs, type I interferon (IFN) system, complement system and platelets. In the first papers we studied the plasmacytoid dendritic cell (pDC) and properties regulating their IFN-alpha producing ability, a central cytokine in the SLE pathogenesis. We found …
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Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
… the innate cytokines interleukin 12 (IL-12) and type I interferon (IFN-alpha/beta) are produced in response to intracellular bacterial and viral infections. While the effects of IL-12 on CD4+ T cell differentiation are relatively well-understood, the role of IFN-alpha/beta, despite extensive …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… cascade that leads to the production of type-I interferons and proinflammatory cytokines necessary to trigger the protective defenses of the immune system. Critical to this pathway is the activation of a kinase, TANK binding kinase 1 (TBK1), which phosphorylates the downstream …
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Cytokine modulations by type I interferon suppression-negative and NF-κB activation-negative Porcine Reproductive and Respiratory Syndrome Virus
… (PRRSV) suppresses innate immunity, namely, type I interferons (IFNs-α/β) during infection and predisposes infected hosts to secondary bacterial infections. PRRSV also activates NF-κB signaling such that the secondary infection may trigger enhanced expression of proinflammatory cytokines. …
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Identification and Characterization of Interferon-Stimulated Regulators of Bacterial Infection
The type I interferon activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes as a model bacterial pathogen, I sought to identify the roles of …
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Sensing Foreign DNA: The Role of DNA-PKcs in Human Anti-viral Innate Immunity
… signalling axis and the production of type I interferon. Previously, our work identified the non-homologous end-joining protein DNA-PKcs, part of the DNA-dependent protein kinase (DNA-PK) complex, as an intracellular PRR for cytoplasmic viral DNA in murine cells. After screening several …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… to counter virus infection is production of type I interferon (IFN), an innate immune response that generates antiviral state to prevent virus replication and spread by expressing several IFN-stimulated genes. Type I interferon response depends on a set of germ-line encoded receptors called …
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