Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"type I Interferons"”.
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Regulation of type I interferons in murine dendritic cells
… of innate and adaptive immune responses. Type I interferons (IFNs), as important danger signals, activate cDCs through the canonical type I IFN receptor signaling. Type I IFNs are the first line of host defense against viral infection by up-regulating IFN-stimulated genes (ISGs). However, …
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Plasmacytoid Dendritic Cells Sense Skin Injury and Promote Wound Healing Through Type I Interferons
… have the capacity to produce large amounts of type I IFNs (IFN-a/b) in response to viruses or host derived nucleic acid containing complexes. pDCs are normally absent in skin but accumulate in the skin of psoriasis patients where their chronic activation to produce IFN-a/b drives the disease …
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Monogenic Defects of the Type I Interferons Signaling Pathway in Humans: Molecular and Clinical Implications
… regulator of innate anti-viral immunity in the type I and III interferon (IFN) signaling pathways, which share many signaling proteins. Consistent with this role, I show that the patient's cells had drastically reduced responses to type I IFN which led to increased influenza virus replication. …
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
… model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite …
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Regulating Inflammation Through Exercise-Mediated Trained Immunity or Genetic Manipulation of the Interferon Locus
… targeting key immune modulatory factors, such as interferons. In my thesis, I employed both approaches. First, we explored whether exercise training could induce adaptations in bone marrow-derived macrophages, resulting in trained immunity, known to occur in immune cells due to persistent …
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Type 1 Interferon: A Negative Regulator Of Myeloid-Derived Suppressor Cells Function In Cancer
… well understood. Here, we present evidence that type I interferons (IFN1) receptor signaling in neutrophils and monocytes serves as a universal mechanism that restrict acquisition of suppressive activity by these cells. Downregulation of the IFNAR1 receptor and inactivation of the IFN1 pathway …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… the expression of pro-inflammatory cytokines and type I interferons (IFN) through the activation of the transcription factors including IFN regulatory factor 3 (IRF3). Interestingly, we found evidence that the same defense mechanisms are implicated in protecting organisms from cancer. We …
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The type I IFN of Bos taurus
The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to rapid expansion in the number and complexity of their genes. IFNT, which is a unique Type I IFN restricted to pecoran ruminants, also has a specialized role in maternal …
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The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… poorly understood. Recent work has shown that Type I Interferons, inflammatory cytokines typically produced in response to viral infection, are present in the post-mortem brains of human TBI patients. The cyclic GMP-AMP Synthase- Stimulator of Interferon Genes (cGAS-STING) pathway is one of the …
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Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
… evidence of infection within the first year. Type I interferons (IFN) and interferon inducible genes are responsible for the innate antiviral state and single nucleotide polymorphisms (SNPs) within these genes may affect the patients ability to respond post-transplantation. We hypothesize the …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… immune responses including the production of type-I interferons (IFNs). Endogenous DNA that is inappropriately cleared can also accumulate in cytosol and drive pathological inflammation and autoimmune diseases such as systemic lupus erythematosus (SLE). It is well known that cytosolic DNA …
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Engineering Intratumoral Cytokine Therapies for Cancer
… and retention is an effective strategy for type I interferons (IFN). Significant enhancement in tumor retention of IFN and IFN, mediated by anchoring these IFNs to co-injected aluminum-hydroxide (alum) particles, greatly improved their tolerability and efficacy. The improved efficacy of …
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Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune surveillance responses. In addition to their nuclear …
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LPS from subgingival plaque and the periodontal pathogen Porphyromonas gingivalis, its effect on M1 and M2 macrophage responses and potential as a biomarker
… events conferred by a combination of TNF-α, type-I interferons and epigenetic regulation.
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Apoptosis of Peripheral Blood Leukocytes in Systemic Lupus Erythematosus: Studies on Serum Induction and Complement-Dependent Clearance Mechanisms
… seems to be involved. In SLE upregulation of type I interferons, a hyperactive B-cell response, presence of autoantibodies against modified nuclear components, increased complement consumption, increased apoptosis and decreased clearance of apoptotic cells are seen. The purpose of this thesis …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… cascade that leads to the production of type-I interferons and proinflammatory cytokines necessary to trigger the protective defenses of the immune system. Critical to this pathway is the activation of a kinase, TANK binding kinase 1 (TBK1), which phosphorylates the downstream …
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Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity
… transcription factors regulate the production of type I interferons and proinflammatory cytokines, which serve to keep virus infections under control. RIG-I and MDA5 contain N-terminal tandem CARD domains. CARD domains in other proteins are known to mediate protein-protein interactions. MAVS also …
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… factors, NF-kB and IRF3, in the induction of type I interferons (IFNs) and IFN-stimulated genes (ISGs) that ultimately establish an antiviral state. These signaling pathways are central to host antiviral defense and thus become targets for viral interference. Hepatitis A virus (HAV), a …
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Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
… and enhance the efficacy of existing treatments. Type I interferons (IFNs), particularly IFNβ, are cytokines with well-characterized antiviral and anti-proliferative actions and documented capacity to trigger apoptosis in tumour cells, including NB. In this study, we investigated whether OEA and …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… and late, showed patterns characteristic of type I interferon (IFN) exposure. We next examined experimentally the possible proximal causes of the observed transcriptional profiles. We analyzed the gene expression patterns induced by TGFβ, 13 type I interferons, as well as recombinant HIV Tat …
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