Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"type I IFN"”.
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The type I IFN of Bos taurus
The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to rapid expansion in the number and complexity of their genes. IFNT, which is a unique Type I IFN restricted to pecoran ruminants, also has a specialized role in maternal …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early post viral infection, there is induction and secretion of IFN-β which alerts nearby cells and primes leukocytes for an immune response. A rapid response is necessary for effective control of virus …
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Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
… O (LLO) and infects a variety of cell types including dendritic cells (DC). Our laboratory and others have shown that optimal DC maturation occurs when <italic>Listeria</italic> gain access to the host cytosol, and this correlates with protective immunity.
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Cryptosporidium Uses Its Cspv1 Virus to Activate Host Type I IFN Response and Attenuate IFN-Gamma-Mediated Epithelial Anti-Parasitic Defense
… and host anti-parasitic defense. Interferon (IFN) family is a group of cytokines that play essential roles in host innate and adaptive immunity against pathogen infections. There are three types of IFNs and all three types of IFN signaling have been observed in intestinal epithelium following …
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The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection
The type I interferon: IFN) cascade is critical in control of herpes simplex virus type I: HSV-1) infection and relies on specific recognition molecules to rapidly signal viral infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or …
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Regulation of type I interferons in murine dendritic cells
… of innate and adaptive immune responses. Type I interferons (IFNs), as important danger signals, activate cDCs through the canonical type I IFN receptor signaling. Type I IFNs are the first line of host defense against viral infection by up-regulating IFN-stimulated genes (ISGs). However, …
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Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells
… to infectious agents. Using the expression of type I interferon (IFN) as a benchmark of antiviral responses, our results indicated that the type I IFN were robustly induced in C3Hl0Tl/2 cells, but not in ESCs, when they were exposed to polyinosinic:polycytidylic acid (poly(I:C), a dsRNA viral …
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Characterizing novel molecular regulators of antiviral gene expression
… state and initiation of inflammatory responses, type I interferons (IFNs) are particularly important, as they potently induce the production of hundreds of IFN-stimulated genes (ISGs), many of which have antiviral functions. The type I IFN response requires tight molecular coordination to achieve …
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
… model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
… amounts of pro-inflammatory cytokines, including IFN-alpha. Furthermore, ICs might activate platelets and thus be involved in the development of cardiovascular diseases which is increased in SLE patients. In this thesis I have investigated the immunopathogenesis of SLE with an emphasis on ICs, …
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Monogenic Defects of the Type I Interferons Signaling Pathway in Humans: Molecular and Clinical Implications
… regulator of innate anti-viral immunity in the type I and III interferon (IFN) signaling pathways, which share many signaling proteins. Consistent with this role, I show that the patient's cells had drastically reduced responses to type I IFN which led to increased influenza virus replication. …
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Contributions of type 17 immunity and type I interferon signaling to Salmonella-induced autoimmunity
… autoimmune sequelae remain unclear, type 17 and type I interferon (IFN) signaling play significant roles in the pathogenesis of many classical autoimmune diseases and bacterial infections. Previous research from our lab has shown that Salmonella biofilm-associated amyloid protein, …
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Investigating HSV-1 pUL56 mediated antagonisation of DNA sensing mechanisms
… this, is through the viral protein pUL56, a type-II transmembrane protein within the tegument of HSV-1, that protrudes into the cytoplasm when expressed in infected cells. HSV-1 pUL56 funcAons as an E3 ubiquitin ligase adaptor protein, interacting with the WW domains of the NEDD4 family of …
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Type B Presentation from HEL Protein in the Context of Inflammation
… a given pMHC pair are allowed, generating both type A and B pMHC complexes. Protein traffics to the late endosomal compartment and is loaded onto nascent MHC II in the presence of the editor H2-DM where type A pMHC conformers are selectively formed, generating exclusively type A pMHC from …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… adaptive immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and tumors. Although the importance of cDC1s is now well established, the mechanisms that regulate …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
… leads to the upregulation of a maturation phenotype and the production of type I interferon (IFN) as well as the induction of a strongly polarised TH1, IFN-γ dominated allogeneic T cell response. In contrast, monocyte-derived Langerhans cells (MDLC), display only partial maturation phenotype and …
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection including participating in the …
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The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
… NF-κB pathway and the TLR7 signalling pathway to type I IFN induction. We propose that DDX3X acts as a scaffolding protein that brings together IKKα and its substrates.
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… versus bystander cells exposed to paracrine type-I interferon (IFN). Infected cells downregulated Clec2d nascent transcripts, mainly due to absence of RNAPII recruitment to the Clec2d promoter. Moreover, a cell-autonomous role for the MCMV ie3 gene product was also discovered, whereby ectopic …
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… factors, NF-kB and IRF3, in the induction of type I interferons (IFNs) and IFN-stimulated genes (ISGs) that ultimately establish an antiviral state. These signaling pathways are central to host antiviral defense and thus become targets for viral interference. Hepatitis A virus (HAV), a …
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