Global ETD Search
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Showing 1 to 5 of 5 for “"type 6 secretion system"”.
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Contribution of Secretion Systems to Macrophage Polarization and Cell Death During Burkholderia pseudomallei Infection
… intracellular pathogen, B. pseudomallei uses secretion systems as primary virulence factors. The type 3 secretion system (T3SS) is used to escape the phagosome while the type 6 secretion system is responsible for cell-to-cell fusion and multinucleated giant cell (MNGC) formation. Both …
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Important role of the type VI secretion system in the virulence of an emergent human pathogen Aeromonas hydrophila: Delineating the mechanism of action of its effectors
… In this study, we characterized the new type 6 secretion system (T6SS) from isolate SSU of A. hydrophila and demonstrated its role in bacterial virulence. We have provided evidence that the T6SS is independent of other secretion systems and that the vasH gene is essential for the …
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Secretion of the chitinolytic machinery in Serratia marcescens
There are six known secretion systems in Gram negative bacteria, referred to as Type 1 to Type 6 respectively, which are dedicated to moving substrate across the outer membrane. Secretion systems are broadly separated into those that move their substrate across the cell envelope in a single …
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Investigation into the transcriptional regulation and role in virulence of the Type VI Secretion System of <em>Serratia marcescens</em> Db10
The Type 6 Secretion system (T6SS) is the most recently identified secretion system in Gram-negative bacteria. It is widely distributed and has been found to target both eukaryotic and prokaryotic cells. The T6SS has been described as resembling an inverted bacteriophage cell puncturing device …
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Combating Plague: Fighting a War on Two Fronts Through Vaccine Design and New Therapeutic Intervention
… interruptions in genes encoding hypothetical type VI secretion system components. Through the generation of several T6SS associated gene deletion mutants, we have shown significant attenuation of the bacterium in pneumonic models of plague. Combinatorial deletions of T6SS associated genes …