Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"type 1 myotonic dystrophy (DM1)"”.
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Advances in high-throughput screening: better compounds, novel targets, enhanced sensors
… RNA-protein binding interaction responsible for type 1 myotonic dystrophy (DM1), a hereditary degenerative disorder. Finally, Chapter 4 will explore the limits of small-molecule detection in a novel laser-based optical biosensor technology. Taken together, these three stories encompass the full …
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Developing potential drugs for the treatment of myotonic dystrophy: from rational design to lead development
Myotonic dystrophy (DM) is currently an incurable genetic disease that affects 1 in 8,000 humans worldwide. Although extensive efforts have been made to understand its pathogenesis, the mechanism by which DM causes its symptoms is not fully understood. Nevertheless, it is known that the alternative …
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RNA recognition: controlling RNA-protein complexes with small molecules
… disease, Fragile X mental retardation, and myotonic dystrophy type 1. Myotonic dystrophy (DM1 and DM2) is an autosomal dominant neuromuscular disorder associated with a (CTG)n and (CCTG)n expansion in the 3’-untranslated region of the Dystrophia Myotonica protein kinase (DMPK) gene. The …