Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"type 1 interferon"”.
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Type 1 Interferon: A Negative Regulator Of Myeloid-Derived Suppressor Cells Function In Cancer
… well understood. Here, we present evidence that type I interferons (IFN1) receptor signaling in neutrophils and monocytes serves as a universal mechanism that restrict acquisition of suppressive activity by these cells. Downregulation of the IFNAR1 receptor and inactivation of the IFN1 pathway …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… the innate cytokines Interleukin-12 (IL-12) and type I interferon (IFN-a/b) are induced to high levels by intracellular bacterial and viral infections and have been shown to promote adaptive T lymphocyte responses to infection. While the role for IL-12 on the development of T lymphocyte effector …
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SAFETY, EFFICACY, AND IMMUNOGENICITY OF SARS-COV-2 MRNA VACCINES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
… like systemic lupus erythematosus (SLE), a type 1-interferon-driven disease, remain uncertain, as their mechanism of inducing T-cell-mediated responses and antibody production may risk exacerbating underlying immune dysregulation. This study evaluated immune responses to mRNA COVID-19 …
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Investigations into the viral molecular determinants of lethality of Punta Toro virus (Bunyaviridae, phlebovirus) in the Syrian hamster.
… that the NSs gene encoded by the S segment is a type 1 interferon antagonist. Taken together, this evidence indicates a mechanism of pathogenesis whereby early innate immune suppression by the viral NSs gene/protein in infected cells leads to uncontrolled viral replication that ultimately results …
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Defining the Physiological and Molecular Role of Pellino3 in TLR3 Signalling
… in the first line of defence by recognising the type of pathogenic threat encountered and by responding in kind. TLR pathogen interaction triggers the production of a number of pro-inflammatory cytokines and anti-viral mediators to initiate the process of microbial elimination. However, if left …
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Clustering of immune-mediated diseases using genomic data
… escape X-inactivation and a bicluster capturing type 1 interferon response, enriched for samples from patients with systemic lupus erythematosus. I found that whilst it is an advantage that biclustering has sufficient complexity to describe the immune system comprehensively, this also means that …
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Protective or Problematic? Investigating the role of the innate immune receptor NLRX1 as a tumor suppressor or promoter in breast and pancreatic cancer
… are activated by other PRRs, such as NF-κB and type-1 interferon signaling which both have implications in cancer. NLRX1 can regulate additional cancer-associated pathways, such as MAPK and AKT, and cancer-associated functions like metabolism and reactive oxygen species (ROS) production. …
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Effect of HIV infection and pregnancy on parameters of vaginal immunity
… in susceptibility to HIV infection, and two interferon pathways that have been associated with antiviral immune defense. We hypothesized that pregnant women have increased proinflammatory cytokines in genital secretions, potentially putting them at increased risk for HIV infection, and that …
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The Role of The C5A Receptor In Host Defense Against Listeria Monocytogenes
… cytokines such as TNF-α, IFN-γ and IL-6. As Type 1 IFN impedes the host response to Lm through the promotion of splenocyte death, we examined the effect of C5a and C5aR on type 1 IFN expression <em>in vivo </em>and <em>in vitro</em>. Serum levels of IFN-α and IFN-β are significantly higher in …