Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 267 for “"type 1 diabetes"”.
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Multimodal Prediction of Type 1 Diabetes
Type 1 diabetes often presents abruptly with life-threatening symptoms; however, its autoimmune pathogenesis typically unfolds over many years. After autoimmunity has been established, the rate of progression to clinical disease varies markedly between individuals, creating both an opportunity and …
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Aspects of autoantibody epitopes in type 1 diabetes
Type 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to …
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Genetic contribution to type 1 diabetes microvascular complications
Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of beta cells in the pancreas resulting in insulin deficiency, which leads to hyperglycemia and organ damage. T1D patients experience an increased risk of morbidity and mortality due to long-term complications, specifically …
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Poor glycaemic control in adolescents with type 1 diabetes
Many adolescents with type 1 diabetes (T1DM) have suboptimal glycaemic control, increasing the risk of diabetic complications. This thesis explores some of the causes, consequences and therapeutic options for adolescents with T1DM and poor glycaemic control. Insulin resistance occurs in T1DM and …
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Type-1 diabetes risk prediction using multiple kernel learning
… analysis of multiple kernel learning (MKL) for type-1 diabetes risk prediction. MKL combines different models and representation of data to find a linear combination of these representations of the data. MKL has been successfully been implemented in image detection, splice site detection, …
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Type 1 diabetes in children - risk factors and prediction.
… factors are important for development of Type 1 diabetes (T1D). Increased birth weight (BW), increased linear growth and gestational infections are among the reported risk factors. T1D is predictable by analysis of HLA genotypes and islet cell autoantibodies. In this thesis risk factors …
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Association of autoimmune thyroid disease and type 1 diabetes
… istically female and middle-aged at the onset of diabetes. Ages at onset of diabetes and of thyroid dysfunction were correlated, suggesting the possibility of a common and coincident pathogenesis. Insulindependent diabetics with coexisting autoimmune thyroid disease showed a higher prevalence of …
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Prediction and Detection of Hypoglycaemia in Type 1 Diabetes
Patients with Type 1 Diabetes still suffer from recurrent and troublesome hypoglycaemia despite improvements in glucose monitoring, insulin delivery and structured education. The key objectives of my thesis were to explore ways to identify patients at greater risk to develop hypoglycaemia and to …
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… a different paradigm of metabolic disease, the type-1 diabetic heart becomes more dependent upon the oxidation of fatty acids (FAO) for ATP synthesis due to an inability to regulate blood glucose concentration. The work presented in this thesis aimed to further our understanding of substrate …
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Glycaemic control in pregnancies complicated by type 1 diabetes
Type 1 diabetes in pregnancy is associated with higher rates of maternal and infant complications. The complications are associated with maternal hyperglycaemia. Thus, the main goal of treatment for these women is to optimise glycaemic control and thereby improve clinical outcomes for themselves …
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Early life phenotypes of type 1 diabetes genetic risk
… studies have shown that children who develop type 1 diabetes (T1D) have larger size at birth — a marker of foetal growth — or rapid postnatal weight gains. Recent studies have explored the contribution of the T1D susceptibility human leukocyte antigen (HLA) alleles, which explain half of …
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Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
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Microencapsulated human islets as a therapy for type 1 diabetes
… are to become a viable option as a therapy for type 1 diabetes in humans.
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The role of inflammation in type 1 diabetes-related complications
Contains fulltext : 302597.pdf (Publisher’s version ) (Open Access)
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Auditory-vestibular function in adults with type 1 diabetes mellitus
Diabetes mellitus (DM) is a universal health problem. According to the International Diabetes Federation (IDF), 425 million people world-wide are affected by DM. With such high incidence of DM, health professionals aim to avoid possible secondary disorders which impact health related quality of …
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Anxiety, illness, beliefs and management of child type 1 diabetes
This portfolio thesis is comprised of three parts; a systematic literature review, an empirical study and a set of appendices.
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Hypoglycaemia in type 1 diabetes: risk factors, symptoms and recovery
… commonest side-effect of insulin treatment for diabetes mellitus. Appreciation of the risk factors for hypoglycaemia and early recognition of its symptoms can help the affected individual with prompt self-treatment of hypoglycaemia, preventing progression to severe hypoglycaemia. The proposed MD …
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Psychosocial screening in children and adolescents with type 1 diabetes
Management of Type 1 Diabetes (T1D) in children and adolescents is challenging. Psychological and social factors may explain why many young people fail to adequately control their diabetes. Research examining the potential benefits of introducing psychosocial screening into routine clinical care is …
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The genetics of type 1 diabetes: family and population studies
Type 1 (insulin-dependent) diabetes mellitus is caused by autoimmune destruction of insulin-producing pancreatic ß-cells. Genetic susceptibility is necessary for the development of type 1 diabetes but inheritance does not follow simple Mendelian rules and environmental factors are also involved. …
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Closed-loop insulin delivery in adults with type 1 diabetes
Achieving tight glucose control safely in type 1 diabetes with currently available methods of insulin delivery is challenging. Aggressive regimens carry an increased risk of hypoglycaemia, particularly overnight. Both alcohol consumption and exercise predispose further to low glucose levels. The …
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