Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"two-component signaling"”.
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Mechanism and specificity of bacterial two-component signaling systems
Bacterial two component signaling (TCS) systems are the predominant means by which bacteria sense and respond to external signals. These systems represent a large family of paralogous proteins; often hundreds of the histidine kinase (HK) and response regulator (RR) pairs that make up a TCS system …
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Investigation of two-component signaling systems in Pseudomonas aeruginosa and their roles in the mucus barrier
… a common means through which this occurs is via two-component signaling systems, which are typically comprised of a membrane-bound histidine kinase that senses external cues signals, and a cognate cytoplasmic response regulator that triggers changes in gene expression. The importance of these …
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Regulation of cell fate asymmetry in Caulobacter crescentus by a complex of two component signaling proteins
Cellular asymmetry is critical to the generation of complexity in both metazoans and many microbes. However, several molecular mechanisms responsible for translating asymmetry into differential cell fates remain unknown. Caulobacter crescentus provides an excellent model to study this process …
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Engineering orthogonal signaling pathways to probe sequence space capacity
… and powerful mechanism by which cells create new signaling pathways, but recently duplicated proteins typically must become insulated from each other, and from other paralogs, to prevent unwanted cross-talk. A similar challenge arises when new sensors or synthetic signaling pathways are engineered …
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Pervasive degeneracy and epistasis in a protein-protein interface
… library-based mutagenesis studies of bacterial two-component signaling pathways. These pathways, typically consisting of a histidine kinase and a response regulator, are an ideal model system for studying protein-protein interactions as they rely almost exclusively on molecular recognition for …
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Signaling between Two Sensor Kinases Controls Biofilms and Host Colonization in a Bacterial Symbiont
… common sensory pathway utilized by bacteria is two-component signaling (TCS), composed of an environmental sensor (the sensor kinase, SK) and a cognate, intracellular effector (the response regulator, RR). The marine bacterium Vibrio fischeri uses an elaborate TCS phosphorelay containing a …
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Targeting Receptor-Histidine Kinase Signaling in Staphylococcus Aureus
<p>Two-component signaling systems involving receptor-histidine kinases (RHKs) are present in all branches of life outside of the animal kingdom. Remarkably, very little is known concerning the extracellular ligands that presumably bind to RHKs to initiate signaling. The two-component agr signaling …
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Cell Envelope Modifications By Lcp Family Proteins Of Group B Streptococcus And Virulence Singaling By Peptides Of The Salivaricin Locus Of Streptococcus Pyogenes
… PROTEINS OF GROUP B STREPTOCOCCUS AND VIRULENCE SIGNALING BY PEPTIDES OF THE SALIVARICIN LOCUS OF STREPTOCOCCUS PYOGENES</p> <p>by</p> <p>HANNAH MORRISON ROWE</p> <p>December 2014</p> <p>Advisor: Dr. Melody Neely</p> <p>Major: Immunology and Microbiology</p> <p>Degree: Doctor of Philosophy</p> …
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The Characterization of Quorum Sensing E. Coli Regulators E,F, and G (Qse EFG) and Their Role in Pathogenesis
… has been well-characterized and involves the two-component sytem QseBC. Less is known about the signaling towards EHEC's AE lesion formation capability. Here, we describe a unique signaling system important for EHEC pedestal formation. In contrast to conventional two-component signaling …
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Specificity and evolution of bacterial two-component signal transduction systems
… enabling cells to quickly increase their signaling capacity. After duplication, however, all pathway components are identical in sequence and function. To evolve a new role, the pathways must become insulated at the level of signal transduction. Two-component signal transduction systems, …