Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"tumourigenesis"”.
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Insulin Recepto Loss Impairs Mammary Tumourigenesis in Mice
Breast cancer (BC) prognosis and outcome are adversely affected by increased body weight, obesity, and the obesity-associated type 2 diabetes. Hyperinsulinemia, common in the obese state, has been associated with higher risk of death and recurrence in BC. Up to 80% of breast cancers overexpress the …
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The role of Men1 in pituitary gland tumourigenesis
… and to elucidate the mechanism of MEN1 tumourigenesis I have generated a conditional Men1 mouse model that enables me to specifically delete Men1 in the pituitary gland. Men1 deficient pituitary glands are hyperplastic as early as 7 weeks of age. The hyperplasia often develops into …
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Identifying regulators of neural stem cell fate and tumourigenesis
The proliferation of neural stem cells (NSCs) must be regulated precisely in order to generate a functional nervous system. Mis-regulated NSC division can lead to the inadequate production of differentiated progeny or to ectopic NSCs and tumour formation. As such, genes that promote the …
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Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis
… tumour cells, implicating Cdk5 activity in tumourigenesis. Furthermore, this is the first implication of long-form CRMP2 (CRMP2A) in the nucleus and potentially the isoform associated with cancer. <br/><br/>Overall, the data presented in this study provides a platform in which to improve …
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Evaluating CD44-EZRIN Interactions in Triple-Negative Breast Cancer: Tumourigenesis and Drug Resistance
When breast cancer is detected at an early localized stage, surgery is often successful in achieving long term survival. However, when breast cancer becomes invasive and progresses to metastatic disease, surgery followed by adjuvant therapies is required, and many patients fail to respond or …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
Neural stem cells produce all the cells of the nervous system and regulation of proliferative behaviour is crucial for proper brain development. Over-proliferation of NSCs can also lead to disease, resulting in the formation of tumours. There is a delicate balance between NSC proliferation, …
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Investigating a Role for the Duchenne Muscular Dystrophy Gene in the Tumourigenesis of Head and Neck Cancer
… the details surrounding their involvement in tumourigenesis are poorly understood. Using primary HNSCC tumour RNA-Seq data from The Cancer Genome Atlas (TCGA) database paired with clinical data, the association of DMD expression with survival outcomes was assessed. Kaplan-Meier (KM) analysis …
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A study of succinate dehydrogenase deficient tumourigenesis: From functional assessment of variant pathogenicity to the discovery of new disease biomarkers
… with a predisposition to a spectrum of tumourigenesis including phaeochromocytoma, paraganglioma (1) (PPGL), gastrointestinal stromal tumours (GIST) (2), renal cell carcinoma (RCC) (3) and pituitary adenomas (4). Pathogenic variants in each of the four genes (SDHx) encoding the four …
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The roles of the retinoic acid receptors in growth, differentiation and development.
… I wanted to assess the role of the RARs in tumourigenesis by overexpressing RAR$\alpha$myc in the mammary gland in the mouse. Many cancers arise due to a block in the normal differentiation of an undifferentiated precursor cell and I postulated that the RAR$\alpha$myc, because of its ability …
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Outcomes and optimal treatment of patients with Acromegaly
… I also explored factors influencing pituitary tumourigenesis by characterising mRNA levels for 11β-HSD isozymes in normal and neoplastic pituitary tissue. Results demonstrated reduced 11β-HSDl expression and 10-fold increased 11β-HSD2 expression in pituitary tumours compared with normal …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… stem cell survival, proliferation, apoptosis and tumourigenesis. Previous studies have shown c-Myc dependency for both apoptosis and proliferation following activation of the Wnt pathway, however little is known about the role c-Myc plays in inducing apoptosis following DNA damage in vivo. To …
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Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma.
… understood mechanisms involved in oesophageal tumourigenesis may provide a platform to develop improved diagnostic techniques and therapies. The growth hormone (GH) signalling axis is important for proper cellular and organ system function. The axis has been shown to play a role in a number of …
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The Contribution of Environmental Cues to Early Squamous Tumour Formation in the Upper Gastrointestinal Tract
… and is integral to several stages of tumourigenesis. Thus, the risk and progression of cancer involves a complex interplay between mutant cells and their dynamic environment which is far more intricate than previously understood. However, our understanding of how the pre-cancer …
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The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer
… a novel mechanism by which it contributes to tumourigenesis.
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Tumour suppression mediated through DPC4, p53 and APC
… carcinogen- induced murine models of pancreatic tumourigenesis. Second, it examines the in vitro effects of TGF -ß signalling, of which SMAD4 is the central mediator, on murine primary cultured pancreatic acinar cells. Previously p53 ApcM "i+ mice have been shown to develop pancreatic tumours. To …
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DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis
… did not significantly increase lung or liver tumourigenesis compared to DMSO controls. No difference was observed between ogg1 genotypes, although a non-significant trend towards AFB1-treated ogg1 (-/-) mice being more susceptible to tumourigenicity was apparent. Overall, deletion of ogg1 did …
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Investigating the role of PKC-β in tumour activated stromal cells
… microenvironmental PKC-β enhanced tumourigenesis in a murine lung cancer model that could be targeted by a small molecule inhibitor. Overall, I demonstrate PKC-β to be a novel regulator of the BMSC secretome and that targeting these signalling cascades with small molecule inhibitors …
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Molecular and functional analysis of the tumour antigen T21
… studies on the role of T21 in prostate cancer tumourigenesis. As with the majority of identified cancer/testis antigens, the role of T21 in cancer remains undetermined. Therefore, investigations were initiated to understand the potential function of T21 in cancer cells.
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