Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"tumour-associated macrophages"”.
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… development of CRC is highly influenced by the tumour microenvironment. Tumour cells are able to recruit macrophages and change their behaviour. These tumour-associated macrophages (TAMs) were of the M2 phenotype (CD206+). In CRC patient tissues and xenografts from mouse model, presence of …
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CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients
… and aims A higher proportion of CD68-positive tumour associated macrophages (TAMs) has been associated with poorer outcomes in HIV-negative patients with Hodgkin lymphoma (HL), but whether this is true in HIV positive patients with HL is not known. In this study, we investigated the number of …
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Enhancing Anti-Cancer Immunotherapy by Disruption of the non-Receptor Tyrosine Kinase Fes
… kinase, which is abundantly expressed in macrophages, dendritic cells, NK cells and B cells, as an innate intracellular immune checkpoint. In syngeneic engraftment models of breast cancer and melanoma, FES genetic disruption in the host was associated with delayed tumour growth, improved …
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Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma
… cancer cells account for less than 5% of the tumour microenvironment, yet drug screening and treatment strategies typically focus on targeting malignant cells. Tumour-associated macrophages (TAMs) are associated with poor prognosis and resistance to therapy; however, there remains an unmet …
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Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models
… are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
This project focuses on two tumours of the nervous system, schwannoma and meningioma. A large group of schwannomas and meningiomas display the inactivation of the NF2 gene. The NF2 gene codes for the tumour suppressor protein Merlin and its loss is associated with a multitude of pro-tumourigenic …
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
… phagocytes (MNP), consisting of monocytes, macrophages and dendritic cells (DC), are major cell types of the innate immune system and their activation is required for an effective immune response, including the anti-cancer response. Tumour-associated macrophages (TAM) are a universal feature …
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The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression
… is the most aggressive, fatal, yet most common tumour to affect the central nervous system in adults. With a median survival time of only 15 months following diagnosis, it is a disease of high morbidity and mortality. Immunotherapies have shown great promise in the treatment of other …
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Investigation of the role of Col4a1 and Itga11 in enzalutamide resistance of prostate cancer cells
… and accounts for over 90% of PCa-related deaths. Tumour-associated macrophages (TAMs) can promote ADT resistance in bone metastasis, but the mechanism is yet unknown. Recent studies in our lab have identified that macrophages regulate the expression of a set of extracellular matrix genes that are …
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Role of the extracellular matrix-integrin interaction in enzalutamide resistance of bone metastatic castration-resistant prostate cancer
… options for bone mCRPC patients. Although tumour-cell autonomous mechanisms are increasingly understood, roles played by the tumour microenvironment (TME) in driving Enz-resistance remain less clear. Previous has research revealed that macrophages, as a major TME component, are important in …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… regeneration. Hypothesis: We hypothesised that Tumour-associated macrophages (TAMs), a distinctive cell type within the tumour microenvironment, could represent an innovative therapeutic approach for neuro-regenerative medicine. Indeed, TAMs possess a unique set of properties, including immune …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
Triple-negative breast cancers (TNBC) are usually associated with an aggressive phenotype, an increased risk of early relapse, and poor outcome. Burgeoning evidence demonstrates that TNBC encompasses distinct molecular entities that are differentially characterized by specific hallmarks of cancer, …