Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"tumour vasculature"”.
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CROSSTALK BETWEEN TUMOUR VASCULATURE AND OVARIAN CANCER STEM CELLS: THE ROLE OF L1CAM.
Ovarian cancer is the most lethal gynaecologic tumour, mainly due to relapse and chemoresistance, two events fuelled by ovarian cancer stem cells (OCSC). The tumour microenvironment (TME) is thought to act as a niche for OCSC, preserving stem cells properties and sustaining tumour recurrence. The …
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p38 MAPK Signalling in Endothelial Apoptosis
… proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main …
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Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach.
… chemotherapy. There is evidence to suggest that tumour vasculature is the main target of this dosing schedule resulting in an overall ‘non specific’ anti-angiogenic effect. It is now being studied in clinical trials alone and in combination with specific antiangiogenic agents.This thesis had two …
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting a passive tumour targeting property. Functionalised tetraazamacrocycles based around the cyclam and cyclen structures form …
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Oscillations in microvascular flow : their relationship to tissue oxygenation, cellular metabolic function and their diagnostic potential for detecting skin melanoma - clinical, experimental and theoretical investigations
Tumour vasculature is known to be inefficient and abnormal due to poorly regulated angiogenesis during tumour growth. This leads to irregular patterns of blood flow which are spatially and temporally heterogeneous. Many investigations into the characteristics of tumours are invasive and performed …
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Elucidating how αvβ3-integrin regulates neuropilin-1’s role in tumour angiogenesis in order to improve anti-angiogenic therapy
αvβ3-integrin expression is vastly upregulated in tumour vasculature, and has long been considered a key molecule in promoting tumour angiogenesis. However, its initial promise as a target in anti-angiogenic therapy has wavered since the αvβ3-integrin antagonist cilengitide did not meet its end …
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Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases
… Overexpression of matrix metalloproteinases in tumour tissues relative to normal tissues has been exploited as a target for peptide-based therapeutics, to improve therapeutic index of currently used agents. The stability of MMP-activated prodrugs in normal tissue or organs is a significant …
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Validation of photoacoustic imaging biomarkers in cancer biology
… and impact of these hypoxic fluctuations on tumour progression have not yet been fully understood. Harnessing the photoacoustic effect, photoacoustic imaging (PAI) holds significant potential to elucidate these dynamics, but to fulfil this potential, a need for a thorough technical and …
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Functional imaging of cancer using Optoacoustic Tomography
Poor oxygenation of solid tumours has been linked with resistance to chemo- and radio-therapy and poor patient outcomes. Measuring the functional status of the tumour vasculature, including blood flow fluctuations and changes in oxygenation is important in cancer staging and therapy monitoring. A …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… of dense stromal fibrosis which distorts tumour vasculature. This limits nutrient, oxygen and chemotherapy perfusion into pancreatic tumours and promotes oxidative stress. The craftsmen of fibrosis are cancer-associated pancreatic stellate cells (CA-PSCs) who drive disease progression, …
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RGD-targeted Solid Lipid Nanoparticles Containing Asiatic Acid for the Treatment of Cancer
… drug carriers. The concept of targeting to the tumour vasculature or angiogenic blood vessels has continued to be of interests in cancer research since 1970s, as it offers promising therapeutic applications for many solid tumours. Active targeting of DDSs relies on specific interactions between …
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Abnormal microvascular phenotypes in a mouse model of glioblastoma and the effect of vessel compression on blood flow
… areas of research in cancer, studying the tumour microenvironment and the physics of cancer has shown promising results for patient benefit, and will be the focus of this thesis. A tumour is an abnormal cell growth, and is cancerous when it has the potential to metastasise. Tumours have …
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Establishment of recombinant antibody technologies allowing for the generation of SNAP-tag fusion proteins
… The acute heterogenicity and complexity of TNBC tumours, together with a lack of well-defined molecular targets, complicates prognosis of the diseases resulting in patient reliance on traditional therapies, like chemotherapy, radiotherapy, and surgery, which are associated with elevated incidence …