Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"tumour stroma"”.
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… mutation seen in ccRCC with more than 90% of tumours had clonal disruption of the VHL pathway. Although it is the initial oncogenic insult in ccRCC, it takes decades after VHL inactivation for ccRCC to develop. To investigate the molecular mechanisms of ccRCC development, a mouse model with …
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Stromal interactions in pleural mesothelioma
… mesothelioma is dominated by loss of function of tumour suppressor genes rather than targetable oncogenes. It is a stromal rich malignancy with cancer cell nuclei frequently accounting for less than 25% of all tumour nuclei. The remainder are largely comprised of stromal cells, the roles of which …
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Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… and CD73 were shown to be highly expressed on tumour-infiltrating immune cells. The distribution of extracellular adenosine appeared heterogeneous in murine PDAC, with high concentrations in hypoxic areas, enriched for myeloid infiltration. M2 macrophages among other myeloid populations, highly …
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The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
… known about the molecular mechanisms underlying tumour cells' alteration of their microenvironment, entrance into the circulation, and colonization of distant organs. In recent years, accumulating evidence has indicated that tumour microenvironment, which consists of a variety of cell types and …
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Defining the pro-tumour impact of the evolving stromal microenvironment
Much like normal tissues, tumours require a supporting microenvironment for growth and survival, known as the tumour stroma. However, tumours represent a dynamic and turbulent environment, in which factors such as hypoxia, fibrosis, nutrient deprivation and the local cytokine milieu continually …
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Immune Infiltrates in Breast Cancer: Clinical Significance from Histopathology to Prognosis
… a central role in prognosis. Overall, increased tumour infiltrating lymphocyte (TIL) counts are associated with better outcomes. However, the prognostic significance of TILs varies by TIL type, with CD8+ (cytotoxic T-cells) generally being associated with better outcomes, and both FOXP3+ …
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Niche disturbances in Chronic Lymphocytic Leukaemia affect HSC residency and drug resistance
… C- (PKC) expressed in activated BM mesenchymal stromal cells (BM-MSCs) which display activation of inflammatory pathways, as well as BM endothelial cells (BMEC) (Lutzny et al., 2013). This activation provides a nurturing environment, which not only contributes to disease progression, but likely …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… immune responses. In particular, the tumour immune microenvironment and the interaction between immune and cancer cells are emerging as crucial factors in tumour progression, prognosis, and response to therapy in TNBC. In this study, we aimed to evaluate the relationship between these …
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
… transition (EMT) signalling and an abundance of stroma (particularly fibroblasts) in their tumour microenvironment. To date, there has been inconsistent data regarding the benefit of standard chemotherapy in these patients with high-fibroblast (HiFi) tumours. Additionally, there is limited …