Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"tumour proliferation"”.
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The pharmacological inhibition of the neuropeptide Y1 and Y5 receptors on proliferation, migration, and cell signaling in hypoxic breast carcinomas
… of these receptors by peptide binding impacts tumour proliferation, migration, invasion, and angiogenesis, especially in hypoxia. Here we show that the use of NPY1R and NPY5R antagonists in MDA-MB-231 and MCF7 breast cancer lines can inhibit hallmarks of cancer and that NPYRs are associated …
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Analysis of methylation status of CGB genes in common nontrophoblastic cancer
… hormone and its unique β-subunit are recognised tumour markers involved in enabling anti-apoptotic pathways, promotion of invasion and angiogenesis, and supporting tumour proliferation leading to more aggressive cancer and poor prognosis. The limiting factor for the hCG production is the presence …
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The Development of Novel Tools for the Metabolic Labelling of Glycans in Cancer
Aberrant cell surface glycosylation is key in tumour proliferation, metastasis, and immune evasion, with hypersialylation one of the alterations most observed in tumour cells. Changes in the glycome can be monitored by incorporating unnatural sugars bearing bioorthogonal chemical reporters. …
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Investigation of the role of ARFGEF3 in breast to brain metastasis
… cancer is one of the most common malignant tumours. Although the survival rate of breast cancer has improved in recent years, still it can reappear after a few years and can metastasize to the other part of the body. It is relatively common for breast tumours to metastasize to the brain and …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
Meningiomas and schwannomas are mostly benign tumours of the nervous system that currently have no clinically approved treatments apart from surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. …
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Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies
ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… models fail to recapitulate patient-specific tumour–immune interactions. To address this and enable testing the growing number of possible treatment combinations, I aimed to establish autologous preclinical immune modelling of ccRCC in vitro using expanded patient-derived ccRCC, kidney and …
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Life Style, Molecular Pathology, and Breast Cancer Risk
… breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. A major aim of this …