Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"tumour progression"”.
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Proteomics characterization of HPV-independent Vulvar Cancer Tumour Progression and Metastasis by Mass Spectrometry
… cancer available in the clinical practice yet. Tumour biomarkers, such as TP53 and CA125, do not have enough sensitivity and specificity in vulvar cancer detection. Therefore, new protein biomarker candidates are needed for current vulvar cancer diagnosis and prognosis. Mass spectrometry (MS) is …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
The leading cause of cancer deaths is tumour metastasis. The formation of metastases is a complex multistep process, involving invasion of the basal membranes and connective tissue, penetration of the blood vessel walls, invasion of the host tissue, and initiation of growth at the new location. The …
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The critical role of histone methylation in tumour progression and as anti-cancer targets in neuroblastoma
… neuroblastoma cell proliferation in vitro and tumour progression in neuroblastoma-bearing mice. In a publicly available microarray gene expression dataset, high levels of DOT1L gene expression in tumours correlated with high levels of MYCN gene expression and poor patient survival independent …
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Multiscale modelling of cancer invasion: the role of dynamic fibre redistribution and matrix-degrading enzymes in tumour progression
… in cell-cell and cell-matrix adhesion, the tumour is able to spread into the surrounding tissue. The ECM constituents are favourably explored by the cancer cells during invasion, and in this context, of particular importance is the special contribution of ECM fibrous proteins components, …
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Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… with adverse outcome independent of the tumour stage (p=0.046). Furthermore, this copy number gain correlated with Oncostatin M receptor (OSMR) overexpression and sensitised these cells to Oncostatin M (OSM) leading to increased Signal transducer and activator of transcription 3 (STAT3) …
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Development of in vitro models of invasion for the pharmacological investigation of small molecule inhibitors of tumour progression. Development and validation of a 3-dimensional tumour spheroid invasion model to evaluate the pharmacological effects of novel small molecule β3 integrin antagonists.
Tumour dissemination is a major reason for failure of therapy for many tumour types therefore there is a requirement for novel targets & therapies. The αIIbβ3 and αvβ3 integrins have been demonstrated to have significant involvement at many stages of the tumour dissemination process including, …
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Immune cell alterations in mouse models of prostate cancer
Numerous studies have demonstrated that tumour cells have the ability to alter immune function to create an immune suppressed environment. This allows tumour cells to escape immune surveillance and consequently the tumour can progress. Dendritic and T cells have critical roles in immune activation …
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Digital Profiling of Circulating Extracellular Vesicles at Single-Upconversion Nanoparticle Sensitivity and Resolution
… (EVs) carry significant information about the progression stages of tumour sites. Quantification of low-abundant EVs and statistical profiling of the heterogeneity of single EVs, particularly from liquid biopsy sampling, will guide clinical decisions on the stages of tumour progression. …
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A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… to identify molecular markers that can determine progression of low grade glioma. This was done using various approaches such as IDH1 and IDH2 mutation analysis, MGMT methylation analysis, copy number analysis using array comparative genomic hybridisation and identification of differentially …
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Effects of Oncostatin-M Receptor overexpression on cervical squamous cell carcinoma cells and their extracellular vesicles
… with an adverse overall survival independent of tumour stage. OSM-OSMR signalling activates STAT3 and MAP-kinase pathways and induces a pro-malignant phenotype including increased cell migration, invasion and angiogenesis. Bidirectional communication between cancer cells and cells of the tumour …
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A study of activation antigens involved in the pathologicalmechanisms and pathways of cutaneous malignant disease withparticular emphasis on cutaneous T cell lymphoma andmalignant melanoma
… to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis. Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression.
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… linked to signalling, cell communication and tumour progression. This study has shown that cluster of differentiation (CD) 74 and CD44 act in synergy and are susceptible to the effect of the macrophage migration inhibitory factor (MIF). MIF is a 12.5 kDa chemokine-like inflammatory mediator, …
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17-AAG and sihsp90α combinational therapy as a novel anti-cancer approach
… Hsp90 is known to be highly expressed in tumour cells where it regulates stability and function of several key oncogenic client proteins including Akt kinase, EGFR, CDK and PDGFR. These client proteins are mutated or overexpressed in tumours and are involved in tumour progression and …
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Proteomic analysis of biomarkers associated with immunotherapy in murine tumour models
… efficacy of immunotherapies and to investigate tumour immunity in general and the mechanisms involved in tumour progression. These models provide an in vivo environment which cannot be reproduced in vitro, which results in more accurate and reliable information on the host response to …
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Unbiased global proteomic profiling of patient-derived meningiomas of all grades to identify molecular signatures of differentially expressed proteins and phosphoproteins.
… is the most frequent primary intracranial tumour. Surgical resection remains the main therapeutic option as pharmacological intervention is still hampered by the poor knowledge of the molecular signature of these tumours. In order to elucidate the proteomic profiling of meningiomas and …
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On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.
Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive …
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Telomerase a prognostic marker an therapeutic target
… glioma is the most common and aggressive form of tumours and is usually refractory to therapy. Telomerase and its altered activity, distinguishing cancer cells, is an attractive molecular target in glioma therapeutics. The aim of this thesis was to silence telomerase at the genetic level with a …
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The role of PAK6 in HGF-induced prostate cancer cell migration
… cells move from the primary site and establish tumours at a secondary location. During tumour progression cancer cells can assume a migratory phenotype which is characterised by cell-cell dissociation and single cells adopting a migratory morphology. Hepatocyte growth factor (HGF) signalling is …
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Inhibition of the autophagy pathway modulates osteosarcoma chemoresistance
… is the most common primary malignant bone tumour. Although the introduction of chemotherapy has improved the survival rate of osteosarcoma patients, chemoresistance remains a major clinical problem underlying poor survival outcome. Previous studies have shown that deregulation of a cell …
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