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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 33 for “"tumour microenvironment (TME)"”.

  1. CROSSTALK BETWEEN TUMOUR VASCULATURE AND OVARIAN CANCER STEM CELLS: THE ROLE OF L1CAM.

    BARONIO, MICOLUniversità degli Studi di Milano2024

    Ovarian cancer is the most lethal gynaecologic tumour, mainly due to relapse and chemoresistance, two events fuelled by ovarian cancer stem cells (OCSC). The tumour microenvironment (TME) is thought to act as a niche for OCSC, preserving stem cells properties and sustaining tumour recurrence. The …

    milano Repository record

  2. Antioxidant PRDX1 limits CD8+ T cell effector function in the tumour microenvironment

    Wesolowski, AlexanderUniversity of Cambridge2024

    … in detecting and orchestrating effective anti-tumour immunity. However, under this selection pressure, cancer cells progressively evolve mechanisms to undermine and subvert host immunity. Immunotherapy aimed at restoring or enhancing endogenous CD8+ T cell function has had profound clinical …

    cambridge Repository record

  3. Graph Representation Learning to Study the Tumour Microenvironment

    Martin Gonzalez, PaulaUniversity of Cambridge2023

    The progression and treatment response of cancer is influenced by the intricate tissue structure where cancer cells are embedded, known as the tumour microenvironment (TME). Recent technical advances allow the acquisition of highly multiplexed biomedical images (HMBI) that generate spatial tissue …

    cambridge Repository record

  4. Investigating the impact of ageing on the tumour microenvironment and its crosstalk with malignant cells in pancreatic cancer

    Araos Henriquez, JoaquinUniversity of Cambridge2024

    … (PDAC) is characterised by an extensive tumour microenvironment (TME), which contributes to disease progression and therapy response. PDAC primarily affects elderly individuals as patients are typically diagnosed when 70 years old or older. While ageing has been shown to impact the TME …

    cambridge Repository record

  5. Cancer Cartography: Mapping Cancer Evolution in Tissue Space

    Lomakin, ArtemUniversity of Cambridge2023

    … the role of cellular interactions within the tumour microenvironment (TME) and the impact of spatial constraints on cancer evolution. Emerging spatial omics technologies offer the potential to address these gaps, although their application in spatial genomics remains limited. This is …

    cambridge Repository record

  6. Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma

    Smoragiewicz, MartinUniversity of Cambridge2019

    … immunosuppressive mechanism operates within the tumour microenvironment (TME) of PDAC. In the KRasG12D; p53R172H; Pdx1-Cre (KPC) genetically engineered mouse model of PDAC, T cells are excluded from tumour nests and this effect is related to the chemokine CXCL12 produced by FAP+ stromal cells. …

    cambridge Repository record

  7. Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer

    Reid-Schachter, Gillian2017

    … disease despite multiple lines of treatment. Recent studies investigating the tumour immune microenvironment have highlighted the prognostic significance of different tumour infiltrating lymphocyte (TIL) subsets and secreted immune factors in HGSC. However, the mechanisms promoting TIL …

    queens Repository record

  8. Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models

    Zhang, Ting2025

    … are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. …

    plymouth Repository record

  9. Computational profiling of the tumour immune microenvironment

    Cast, OliverUniversity of Cambridge2023

    A tumour comprises not only cancer cells but other populations, including immune and stroma, collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and …

    cambridge Repository record

  10. Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation

    Pelicano Da Cunha Branco Da Costa, CatarinaUniversity of Cambridge2025

    … one of the deadliest cancers, with limited treatment options and poor survival rates. It is characterised by strong driver mutations, extensive epigenetic reprogramming, and a dense tumour microenvironment (TME). A defining feature of the PDAC TME is its fibrotic stroma, which is largely …

    cambridge Repository record

  11. Dissecting the interplay between cytotoxic T lymphocytes and the pancreatic cancer stroma

    Golo, Matteo ; https://orcid.org/0000-0002-1604-3887UNSW, Sydney2026

    … T lymphocytes (CTLs) are key effectors in antitumour immunity, patrolling tissues to detect and destroy cancerous cells by directing cytotoxic granules toward the immunological synapse formed with their target. Although CTL infiltration into solid tumours often correlates with improved patient …

    unsw Repository record

  12. Determining stromal evolution in response to immune checkpoint inhibition

    Moody, WilliamUniversity of Cambridge2022

    … system to recognise and eliminate developing tumours has been hypothesised for over a century, yet only recently has this concept translated to the clinic with the discovery of immune checkpoint inhibitors (ICIs) which reactivate anti-tumour T cells. However, their rapid translation into …

    cambridge Repository record

  13. Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment

    Tulkki, Valtteri Heikki JuhaniUniversity of Cambridge2018

    … with adverse outcome independent of the tumour stage (p=0.046). Furthermore, this copy number gain correlated with Oncostatin M receptor (OSMR) overexpression and sensitised these cells to Oncostatin M (OSM) leading to increased Signal transducer and activator of transcription 3 (STAT3) …

    cambridge Repository record

  14. Investigating the role of the Epstein-Barr virus-encoded oncoprotein, latent membrane protein 1, in cell transformation in vitro

    Davis, Alexandra M.De Montfort University2020

    … (EMT), assuming a mesenchymal phenotype. The tumour microenvironment (TME) has emerged as an important target for cancer therapy, and carcinoma-associated fibroblasts (CAFs) are known to play a vital role in the TME: research suggests that both fibroblasts and epithelial cells (via EMT), may …

    de-montfort Repository record

  15. Mapping the spatial organisation of B cells and immune signalling in TNBC to characterise response to immunotherapy

    Ahmad, LubnaUniversity of Cambridge2025

    … states of spatial organisation within the tumour microenvironment (TME), which likely support many of their functional roles. However, the landscape of B cell spatial organisation in cancer and specifically in triple-negative breast cancer (TNBC) is poorly characterised. Organisation and …

    cambridge Repository record

  16. The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression

    Macapagal Foliaki, JenaResearchSpace@Auckland2024

    … is the most aggressive, fatal, yet most common tumour to affect the central nervous system in adults. With a median survival time of only 15 months following diagnosis, it is a disease of high morbidity and mortality. Immunotherapies have shown great promise in the treatment of other …

    auckland-ms Repository record

  17. Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs

    Zimarino, CarloUniversity of Cambridge2021

    … heterogeneous immune population found within the tumour microenvironment (TME). We sought to explore the potential role of microenvironment components on the suppressive behaviour, development and maintenance of MDSCs, focusing mainly on the role of the SIRPα-CD47 signalling axis. In an orthotopic …

    cambridge Repository record

  18. Development of a hydrogel-based microfluidic model of the lymph node

    Mazzaglia, CorradoUniversity of Cambridge2022

    … specific immune responses. In cancers, the tumour-draining lymph node (TDLN) is the site of initial anti-tumour immune response. The TDLN undergoes dramatic reprogramming in response to tumour drainage that is still partly unclear. In vivo models do not easily permit us to follow events …

    cambridge Repository record

  19. The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)

    Abderahman, Sama'Queen's University Belfast2020

    … is a heterogeneous aggressive type of mammary tumour which lacks a definite tailored therapeutic approach, consequently limiting treatment options to chemotherapeutic agents. Doxorubicin has demonstrated significant efficacy in the treatment of TNBC although many patients experience recurrent …

    qu-belfast Repository record

  20. The Role of Autotaxin in Cancer

    Maggs, LaurenUniversity of Cambridge2023

    … in Phase 1B clinical trials for the treatment of patients with metastatic pancreatic cancer, in combination with gemcitabine. ENPP2 is overexpressed in both pancreatic adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC). In HCC, ATX is produced by both the tumour microenvironment …

    cambridge Repository record

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