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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 122 for “"tumour microenvironment"”.

  1. Analysis of the Tumour Microenvironment in CLL

    Hamilton, EmmaKing's College London2013

    … that CLL cell survival can be modulated by tumour cell interactions with the microenvironment in vivo.<br/>The first part of the thesis describes in vitro assays which demonstrated that CLL cell contact with endothelial cells in a co-culture system promotes CLL cell survival. The precise …

    kings Repository record

  2. Characterisation of the Tumour Microenvironment in Ovarian Cancer

    Jiménez Sánchez, AlejandroUniversity of Cambridge2019

    The tumour microenvironment comprises the non-cancerous cells present in the tumour mass (fibroblasts, endothelial, and immune cells), as well as signalling molecules and extracellular matrix. Tumour growth, invasion, metastasis, and response to therapy are influenced by the tumour …

    cambridge Repository record

  3. Graph Representation Learning to Study the Tumour Microenvironment

    Martin Gonzalez, PaulaUniversity of Cambridge2023

    … where cancer cells are embedded, known as the tumour microenvironment (TME). Recent technical advances allow the acquisition of highly multiplexed biomedical images (HMBI) that generate spatial tissue maps of dozens of proteins capturing the intricacies of the TME. Combining the …

    cambridge Repository record

  4. The role of microvesicles in EMT and tumour microenvironment

    Haidery, Ahmad ZiaLondon Metropolitan University2015

    … The influence of carcinoma cell derived-MVs on tumour microenvironment was examined through use of Non-small lung cancer cells (A549) derived-MVs on primary lung fibroblasts (MRC5). MRC5 cells were treated with A549 cell derived-MV produced significantly high level of myofibroblasts marker …

    london-metro Repository record

  5. Antioxidant PRDX1 limits CD8+ T cell effector function in the tumour microenvironment

    Wesolowski, AlexanderUniversity of Cambridge2024

    … in detecting and orchestrating effective anti-tumour immunity. However, under this selection pressure, cancer cells progressively evolve mechanisms to undermine and subvert host immunity. Immunotherapy aimed at restoring or enhancing endogenous CD8+ T cell function has had profound clinical …

    cambridge Repository record

  6. Crosstalk between natural killer cells and cancer associated fibroblasts in the tumour microenvironment

    Nunes Rodrigues, LeonorUniversity of Cambridge2023

    … cytotoxic function is often impaired in the tumour microenvironment. Indeed, difficult to treat solid cancers, like pancreatic cancer, are rich in cancer associated fibroblasts (CAF) which support tumour growth and suppress immune cell functions. Overcoming barriers like CAF-derived immune …

    cambridge Repository record

  7. The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression

    Macapagal Foliaki, JenaResearchSpace@Auckland2024

    … is the most aggressive, fatal, yet most common tumour to affect the central nervous system in adults. With a median survival time of only 15 months following diagnosis, it is a disease of high morbidity and mortality. Immunotherapies have shown great promise in the treatment of other …

    auckland-ms Repository record

  8. MicroRNAs and Extracellular Vesicles: investigating their role in the Testicular Germ Cell Tumour Microenvironment.

    Alonso Crisostomo, LuzUniversity of Cambridge2020

    Testicular germ cell tumours (TGCT) are the most common malignancy in young adult men and are characterised by their broad heterogeneity in terms of differentiation stage, histological presentation and capacity for progression. In addition, the tumour microenvironment (TME) of these tumours varies …

    cambridge Repository record

  9. Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs

    Zimarino, CarloUniversity of Cambridge2021

    … heterogeneous immune population found within the tumour microenvironment (TME). We sought to explore the potential role of microenvironment components on the suppressive behaviour, development and maintenance of MDSCs, focusing mainly on the role of the SIRPα-CD47 signalling axis. In an orthotopic …

    cambridge Repository record

  10. The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy

    Sammut, Stephen JohnUniversity of Cambridge2019

    … of response, though little is known on how tumours and their microenvironments are modulated by neoadjuvant chemotherapy. The thesis aims at molecularly characterising tumour changes during neoadjuvant chemotherapy in a cohort of 168 patients. Serial tumour samples at diagnosis, and, when …

    cambridge Repository record

  11. The role of the tumour microenvironment components in cancer cell behaviour and drug response

    Senthebane, Dimakatso AliceDepartment of Integrative Biomedical Sciences (IBMS)2022

    … reports demonstrate the key role played by the tumour microenvironment (TME) in tumour progression and the development of drug resistance. This study investigated the interactions between cancer cells and the stroma within the TME, specifically fibroblasts, mesenchymal stem cells (MSC), cancer …

    cape-town Repository record

  12. The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment

    Harris, Jennifer NicoleUniversity of Cambridge2019

    … cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a highway for metastatic tumour cells, recent reports propose lymphatics as modulators of immunity, highlighting a need for greater …

    cambridge Repository record

  13. pH Regulatory Molecules In The Tumour Microenvironment: Modulators Of Aggressiveness And Immune Profile Of Human Hepatocellular Carcinoma

    Tuccitto, AlessandraThe Open University2018

    … (HCC) arises in an inflammatory, hypoxic/acidic microenvironment that favours tumour progression and fosters immunosuppression. Tumour cells survive this hostile environment by over-expressing pH regulatory molecules such as carbonic anhydrase (CA) IX, XII and V-ATPase complex, but the relevance …

    the-open-u Repository record

  14. Characterisation of the effect of electroporation and electrochemotherapy on cancer cells and immune cells in the tumour microenvironment

    Bendix, MauraUniversity College Cork2022

    … a locally very effective treatment, with local tumour reduction of up to 85%, while the systemic effects are more varied. For clinical application ECT treatment modalities have been standardized since 2006, after the ESOPE study, which optimized ECT parameters to 8 pulses at 1000V/cm with 100µs …

    cork Repository record

  15. Investigating the impact of ageing on the tumour microenvironment and its crosstalk with malignant cells in pancreatic cancer

    Araos Henriquez, JoaquinUniversity of Cambridge2024

    … (PDAC) is characterised by an extensive tumour microenvironment (TME), which contributes to disease progression and therapy response. PDAC primarily affects elderly individuals as patients are typically diagnosed when 70 years old or older. While ageing has been shown to impact the TME …

    cambridge Repository record

  16. Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models

    Zhang, Ting2025

    … are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. …

    plymouth Repository record

  17. Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention

    Graziano, VincenzoUniversity of Cambridge2023

    … to favour a pro-tumorigenic and tolerogenic microenvironment. Results: Using syngeneic, *in vivo* murine models of PDAC with differential immune infiltration and response to IOT and the KPC mouse model, CD39 and CD73 were shown to be highly expressed on tumour-infiltrating immune cells. The …

    cambridge Repository record

  18. Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment

    Tulkki, Valtteri Heikki JuhaniUniversity of Cambridge2018

    … with adverse outcome independent of the tumour stage (p=0.046). Furthermore, this copy number gain correlated with Oncostatin M receptor (OSMR) overexpression and sensitised these cells to Oncostatin M (OSM) leading to increased Signal transducer and activator of transcription 3 (STAT3) …

    cambridge Repository record

  19. The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis

    Zhang, Yun2013

    … known about the molecular mechanisms underlying tumour cells' alteration of their microenvironment, entrance into the circulation, and colonization of distant organs. In recent years, accumulating evidence has indicated that tumour microenvironment, which consists of a variety of cell types and …

    duke Repository record

  20. PET-MR Imaging of Hypoxia and Vascularity in Breast Cancer

    Carmona-Bozo, Julia CarlotaUniversity of Cambridge2021

    … provide anatomical or structural description of tumours in the clinical setting. It is widely accepted that the tumour microenvironment influences the phenotype, progression and treatment of breast cancer. This gave the impetus to move beyond tumour visualization in images to radiomics in order …

    cambridge Repository record

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