Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"tumour maintenance"”.
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
… whether HIF2α activation is necessary for tumour maintenance. This is of particular interest because current ccRCC therapies are not sufficient and a significant fraction of patients develop resistance. The need for new therapeutic strategies led to development of inhibitors of HIF2α which …
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Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer
… postulates that, akin to normal tissues, tumours are hierarchical and only a rare subpopulation of cells, so-called “cancer stem cells” (CSCs), possess the unique biological properties required for tumourigenesis. In addition to tumour initiation, cancer stem cells are held solely …
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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC
… that MYC, but not CCND1, is sufficient to rescue tumour maintenance upon HIF2A loss. While both cell cycle-associated genes drive proliferative signalling, I demonstrated that only MYC protects from apoptosis, providing mechanistic insights into the role of HIF2A-dependent *MYC* expression in …
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Identification of potential drug targets in glioblastoma using proteogenomic platforms
Glioblastoma Multiforme (GBM) is a solid tumour of the central nervous system. To this date, it is the most aggressive primary brain tumour in adults, and few therapeutic solutions are available. This, in addition to the aggressiveness of the tumour, determine a low survival rate in patients. The …
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Engineering functional recombinant proteins based on antibody domains and fragments of C. botulinum neurotoxin
… receptor present on the surface of various tumour cells. The variable part of chains shows great variability in amino acid sequence among the chains. The unique sequence of amino acid residues for variable fragments leads to the large diversity of structure, which counts for antibody …
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… stem cells (CSCs), which play a pivotal role in tumour maintenance, progression and drug resistance. Aldehyde dehydrogenases (ALDHs) have been used in some tumour types as CSC markers. Their high expression and high functional activity found in CSCs is also associated with drug resistance. …
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Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA
… stem cells (CSCs), which play a pivotal role in tumour maintenance, progression and drug resistance. Aldehyde dehydrogenases (ALDHs) have been used in some tumour types as CSC markers. Their high expression and high functional activity found in CSCs is also associated with drug resistance. …