Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"tumour initiation"”.
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Investigating the role of endoplasmic reticulum stress in neutrophils during tumour initiation
… sites. In recent years, immune suppressive and tumourpromoting neutrophils were found enriched in the tumour microenvironment, suggesting their role in driving the development of cancer. However, the role of neutrophils during tumour initiation is less clear. Studies in zebrafish tumour …
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway
… number of prostate cancer stem cells within a tumour. Tumour initiation, maintenance and spreading have been attributed to this subpopulation of tumour cells. Wnt activity and β-catenin signalling have been associated with different types of cancer and microarray data from our laboratory …
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Decoding mechanisms of brain tumour initiating cell adaption and tumour growth
… (GBM) remains the most common malignant brain tumour with only 5% and 0.76% of patients surviving for 5 and 10 years beyond diagnosis, respectively. The cancer stem cell subpopulation of such tumours has been shown to be responsible for tumour initiation and to be able to recapitulate tumours …
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Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer
… postulates that, akin to normal tissues, tumours are hierarchical and only a rare subpopulation of cells, so-called “cancer stem cells” (CSCs), possess the unique biological properties required for tumourigenesis. In addition to tumour initiation, cancer stem cells are held solely …
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The emerging roles of BAP1 and cancer stem cells in Malignant Mesothelioma
… 1) BAP1 gene. BAP1 is a deubiquitinase and a tumour suppressor, involved in cell cycle, apoptosis, epigenetic modifications and DNA damage response. Herein, it has been demonstrated that BAP1 mutated and silenced MMe cells are more resistant to a DNA damage drug, gemcitabine, causing the …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
… cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel therapeutic targets are thus required to combat this disease. The most effective targets are likely to be factors essential for maintaining ccRCC cell …
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
… of multiple target genes involved in ccRCC initiation. However, it is unclear whether HIF2α activation is necessary for tumour maintenance. This is of particular interest because current ccRCC therapies are not sufficient and a significant fraction of patients develop resistance. The need …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… and in combination with Gemcitabine resulted in tumour growth and metastasis suppression, likely through inhibition of cancer cell proliferation, extracellular matrix degradation, and epithelial-mesenchymal transition (EMT). The combination treatment notably suppressed cancer stemness, a key …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP antagonist Noggin was targeted to the epidermis and …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… dynamics and molecular mechanisms governing tumour initiation and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, little progress has been made in understanding the …
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Endogenous Reporter Systems for High-Throughput Functional Screening in Clear Cell Renal Cell Carcinoma
… carcinoma (ccRCC), loss of von Hippel-Lindau tumour suppressor (VHL), seen in 90% of ccRCCs, leads to the stabilization of hypoxia inducible factor HIF2A and aberrant expression of its downstream targets such as the chemokine receptor CXCR4. Activation of HIF2A has been shown to be important …
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Identifying unique cell states in early liver oncogenesis with transcription coupled repair
… aberrantly. These mutations appear to precede tumour initiation, as DNA sequencing has shown that cancer driver mutations can be found in otherwise-healthy tissues at high levels. Though an increase in mutational burden increases the risk of cancer, not all cells with driver mutations will form …
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Epigenetic dysregulation of novel candidate genes in melanoma
… suggests that they are less effective when tumour load is high and patient performance status poor, as is often the case in advanced disease. New strategies for the early detection of sub-clinical relapsed and/or metastatic disease are therefore urgently required. Development of such …