Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"tumour heterogeneity"”.
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The Intra-Tumour Heterogeneity Landscape of Human Cancers
Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, convey a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. Somatic mutations can be measured through massively parallel …
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Evaluations and Consequences of Tumour Evolution
… lineage, resulting in varying degrees of intra-tumour heterogeneity. Thus, the cancer genome encodes part of the evolutionary history of the tumour. Studying tumour evolution sheds light on the diversity of evolutionary paths to invasive disease and addresses challenges in cancer clinical …
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Inferring tumour evolution from single-cell and multi-sample data
Tumour development has long been recognised as an evolutionary process during which cells accumulate mutations and evolve into a mix of genetically distinct cell subpopulations. The resulting genetic intra-tumour heterogeneity poses a major challenge to cancer therapy, as it increases the chance of …
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DawnRank: discovering personalized driver genes in cancer
… genomic studies have revealed that the genetic heterogeneity of the same type of cancer is greater than previously thought. A key question in cancer genomics is the identification of driver genes. Although existing methods have identified many common drivers, it remains challenging to predict …
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Investigating G-protein coupled receptors as novel biomarkers for diagnosis, prognosis, and targeted therapy in ovarian cancer
… driven by the identification of GPCRs as tumour specific biomarkers. It can be very well imagined that an array of frequently overexpressed GPCRs – matched to ovarian tumour heterogeneity – will in a first step be implemented as a diagnostic tool. In a second step targeted drug carriers …
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SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS
… crucial for personalizing cancer treatment, but tumour heterogeneity presents a challenge in the identification of effective targets. Polo-like kinase 1 is overexpressed near ubiquitously across cancer types and dysregulation of polo-like kinase 1 is closely tied to chromosomal instability and …
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Comparative Study of Colon Cancer Subclones Uncovers Potential Roles for AKAP7 and TP53RK in the Antiviral Response.
Tumour heterogeneity is a key hurdle for the effective treatment of cancer using oncolytic viruses (OVs). A better understanding of the pathways involved in delineating tumour cell resistance and hypersensitivity to OVs is critical in order to guide the development of new therapeutic strategies to …
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T-cell-directed bioorthogonal catalysis for localised prodrug activation in cancer therapy
… remain limited by poor efficacy due to tumour heterogeneity, immune evasion and acquired resistance or dose-limiting toxicities. Immunotherapy opened up new possibilities of targeted treatments to increase specificity, but strategies that enable selective activation of therapeutics at …
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Integration of Genome Scale Data for Identifying New Biomarkers in Colon Cancer: Integrated Analysis of Transcriptomics and Epigenomics Data from High Throughput Technologies in Order to Identifying New Biomarkers Genes for Personalised Targeted Therapies for Patients Suffering from Colon Cancer
… in colon cancer is a challenging task because of tumour heterogeneity. This Ph.D.-thesis presents the molecular and cellular mechanisms leading to colorectal cancer. A systematical review of the literature is conducted on Microarray Gene expression profiling, gene ontology enrichment analysis, …
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Interactions between cancer cells and inorganic materials
… of this threat. One aspect of complexity is tumour heterogeneity, subpopulations of which have been identified as being fundamental to the understanding the formation, progression and treatment of the disease. Cancer stem cells and cells undergoing epithelial to mesenchymal transition are two …
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Studying the Clonal Origins of Drug Resistance in Human Breast Cancers
… arise from pre-existing populations within the tumour, rather than from de novo evolution, yet few studies have experimentally tested this understanding. Indeed, recent reports in the literature have described epigenetically regulated drug tolerant populations within cancers, defined by …
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Machine Learning Methods for Cancer Immunology
Tumours are highly heterogeneous collections of tissues characterised by a repertoire of heavily mutated and rapidly proliferating cells. Evading immune destruction is a fundamental hallmark of cancer, and elucidating the contextual basis of tumour-infiltrating leukocytes is pivotal for improving …
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Preclinical Modelling of Breast Cancer Drug Responses
… disease, exhibiting both inter- and intra- tumour heterogeneity at genomic and phenotypic levels. This remains a key limitation in the treatment of the disease. While recent advances have dramatically improved our understanding and treatment strategies for specific subgroups of patients, …
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Evaluating deep learning for enhanced breast cancer diagnosis: a comparative analysis of CNN architectures
… models, including addressing the complexities of tumour heterogeneity and incorporating multimodal data, will be crucial for their widespread adoption in oncology.
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… known to be highly heterogeneous, but while this heterogeneity has been well studied for IM, little is known about the clonal dynamics in GM and OAC. Clonal dynamics can be explored through longitudinal or multi-sample genomic studies, or experimentally. There is no physiologically relevant in …
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Diagnostic and Prognostic Biomarkers for Early Prostate Cancer
… in prostate cancer. However, the significance of tumour heterogeneity and partial PTEN loss are not clearly defined, nor are interactions between PTEN loss and the TMPRSS2-ERG fusions, the most common genetic aberration found in prostate cancer. We investigated their prognostic utility using …
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The application of genomic technologies to cancer and companion diagnostics.
… quantitation of somatic mutations in circulating tumour DNA, and demonstrate the impact this can have in understanding tumour heterogeneity and evolution during treatment. I also demonstrate how next-generation sequencing technologies may allow multiple genetic abnormalities to be analysed in a …
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Unravelling the Spatial and Temporal Heterogeneity of High-Grade Serous Ovarian Cancer Using Imaging-Based Biomarkers
… by significant spatial and temporal heterogeneity, which has been linked to poor survival outcomes. In this challenging landscape, the quest to characterise heterogeneity through non-invasive image-based biomarkers extracted from routinely collected radiological data is paramount. …
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Somatic evolution in normal human endometrium
… of driver mutations, provided insights into the tumour burdens and underlying mutational processes, sub-clonal diversification and tumour heterogeneity. However, all cancers arise from cells that were once normal. Over time, they acquired certain mutations which increased their fitness, giving …
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Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
As cancer tumours develop, competition between cells will favour those with some mutations over others, creating a dynamic heterogeneous system made up of different cell populations, called sub-clones. This heterogeneity poses a challenge for treatment, as this variety serves to ensure there is …
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