Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"tumour evolution"”.
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Evaluations and Consequences of Tumour Evolution
… of cancer. By the principles of clonal evolution, cancer development is characterized by the acquisition of advantageous driver mutations followed by expansion of the corresponding subclonal lineage, resulting in varying degrees of intra-tumour heterogeneity. Thus, the cancer genome …
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Tumour evolution in ovarian cancer using high-throughput genomics technologies
… if resistance could be explained by the model of tumour evolution. We performed SNP array analysis of a cell line model system of platinum resistance consisting of matched cell lines from three cases of HGSOC established before and after clinical resistance developed, the OVOl clinical study …
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Inferring tumour evolution from single-cell and multi-sample data
Tumour development has long been recognised as an evolutionary process during which cells accumulate mutations and evolve into a mix of genetically distinct cell subpopulations. The resulting genetic intra-tumour heterogeneity poses a major challenge to cancer therapy, as it increases the chance of …
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Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
Immunoediting describes the process in tumour development whereby tumours evolve to avoid the immune system. The relevance of immunoediting in carcinogenesis, metastasis and immunotherapy resistance makes understanding the mechanisms of immunoediting essential in informing cancer therapy and …
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Identification of epigenetically dysregulated genes in tumours that metastasise to the brain
Tumour metastasis to the brain is a common and deadly development in certain cancers; 18-30% of breast tumours metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms plays in metastasis to the brain is not well understood. To identify epigenetic drivers of …
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Polyclonal interactions in intestinal tumorigenesis
… of cancer driver genes, with mutations in the tumour suppressor gene \textit{APC} thought to be necessary and sufficient for transformation. However, large-scale sequencing efforts have uncovered significant intratumoural genetic heterogeneity which is inconsistent with such a linear model of …
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Cellular and molecular mechanisms of response to, and recurrence following, breast radiotherapy
… surgery and radiotherapy. Ipsilateral breast tumour recurrences following breast conserving treatment have long been noted to predominantly occur in or close to the tumour bed from which the index cancer was removed with a smaller number arising in other quadrants of the breast. A widely held …
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Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
… over the last two decades, and the progressive evolution of chemotherapy resistance is common. The development of precision medicine approaches has been significantly impeded by the extreme genomic complexity underlying this disease. HGSOC is characterised by somatic copy number aberrations …
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The somatic evolution of the canine transmissible venereal tumour
This dissertation investigates the evolution of the canine transmissible venereal tumour (CTVT), a sexually transmitted cancer which manifests as genital tumours in dogs. This cancer first arose in an individual dog several thousand years ago, and has since survived by transfer of living cancer …
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Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing
… to a high burden of neoantigens and increased tumour immunogenicity. As a result, hypermutated cancers show the highest response rates to immune checkpoint blockade (ICB), a type of immunotherapy that has revolutionised the treatment landscape for multiple cancer types. Yet, durable responses …
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The Impact of Radiation on Glioblastoma Evolution
… by chemo-radiotherapy. The clonal diversity and evolutionary dynamics inherent to GBs is considered a major obstacle to effective treatment response. While studies have focused on temozolomide, a role for radiotherapy as an independent driver of GB evolution has not been investigated. We …
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A Neural Network and Genome Language Model Based Approach to Understanding DNA Replication in Cancer
… are critical for understanding cancer onset, evolution and treatment resistance. DNA replication during cell division is a tightly regulated process, and maintaining genome integrity requires complete, error-free duplication of the DNA. In this PhD thesis, I leveraged our development of an …
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Characterising Heterogeneity of Glioblastoma using Multi-parametric Magnetic Resonance Imaging
A better understanding of tumour heterogeneity is central for accurate diagnosis, targeted therapy and personalised treatment of glioblastoma patients. This thesis aims to investigate whether pre-operative multi-parametric magnetic resonance imaging (MRI) can provide a useful tool for evaluating …