Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1704 for “"tumour"”.
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Decoding mechanisms of brain tumour initiating cell adaption and tumour growth
… (GBM) remains the most common malignant brain tumour with only 5% and 0.76% of patients surviving for 5 and 10 years beyond diagnosis, respectively. The cancer stem cell subpopulation of such tumours has been shown to be responsible for tumour initiation and to be able to recapitulate tumours …
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Tumour Localisation in Histopathology Images
… the acquisition of manual annotations of tumours in scanned digital slides is still a limiting factor. In this thesis, an automated solution to tumour localisation is explored with the aim of replacing manual annotations. As an exemplar, human breast tissue microarrays stained with …
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Evaluations and Consequences of Tumour Evolution
… lineage, resulting in varying degrees of intra-tumour heterogeneity. Thus, the cancer genome encodes part of the evolutionary history of the tumour. Studying tumour evolution sheds light on the diversity of evolutionary paths to invasive disease and addresses challenges in cancer clinical …
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Nanoemulsion formulations for brain tumour therapy
… This is because the drug cannot reach the tumour site in sufficient amounts. The aim of this project is to investigate the hypothesis that nanoemulsion formulations play an effective role as drug-delivery vehicles for the treatment of glioma. Two commercially available nanoemulsion …
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Studying the Role of Mechanical Properties of Cancer Cells in Tumour Detachment, Migration and Secondary Tumour Formation
Tumour cell detachment, migration and invasion, and secondary tumour formation are critical oncogenic processes during cancer metastasis. Although several molecular mechanisms have been reported to facilitate metastasis, it remains elusive how cellular mechanics contribute to these processes. The …
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Analysis of the Tumour Microenvironment in CLL
… that CLL cell survival can be modulated by tumour cell interactions with the microenvironment in vivo.<br/>The first part of the thesis describes in vitro assays which demonstrated that CLL cell contact with endothelial cells in a co-culture system promotes CLL cell survival. The precise …
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Investigation of candidate imprinted tumour suppressor genes
Imprinting is an epigenetic phenomenon that silences one allele of a gene, so that expression in one or more cell types is exclusively monoallelic, and dependent on parental origin. Approaches used to identify novel imprinted genes rely on characteristic features such as the clustering of imprinted …
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Computational profiling of the tumour immune microenvironment
A tumour comprises not only cancer cells but other populations, including immune and stroma, collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and …
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Circulating Tumour DNA in Localised Urological Cancers
… for non-invasive monitoring of cancer through tumour genome analysis. MutDNA derived from plasma can monitor tumour burden. There is emerging evidence that mutDNA can identify mutations from multiple clones and is abundant in adjacent body fluids. This work explores the utility of plasma and …
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InterNAV2.0: Minimally Invasive Robot-Assisted Tumour Ablative Therapies
… treatment. A platform is being developed for tumour ablative therapies using minimally invasive robotic sys tems. As a proof-of-concept for the platform, a system has been built for Brachytherapy as a treatment for lung cancer. This system uses a navigational software, InterNAVl.0, to …
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Deep Learning-Based Brain Tumour Detection and Classification
Early and accurate detection of brain tumours is essential for improving patient outcomes and guiding effective treatment plans. Traditional diagnostic procedures such as biopsies, performed after brain surgery, are invasive and carry significant risk. With recent advancements in technology, deep …
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Identification of the Apoptin tumour specific kinase/s
… propose a novel role for PKG and PKC in the tumour specific activation of Apoptin in normal and transformed cells. In the absence of PKG, transformed cells activate Apoptin through PKC leading
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A cytochemical and immunological study of tumour cells
Initial tumour growth was found to be exponential following intraperitoneal inoculation of 5 x 106 Ehrlich ascites tumour cells into male BALB/c mice. After three days of this pattern the rate of growth became noticeably retarded and after 12 days a plateau phase ensued. The reduced growth rate was …
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Tumour suppression mediated through DPC4, p53 and APC
Mutations in the tumour suppressor genes SMAD4 (or DPC4, deleted in pancreatic cancer locus 4), APC (adenomatous polyposis coli) and p53 have been implicated in pancreatic cancer in humans. This thesis firstly documents the in vivo effects of mutations in these genes singly and in combination …
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Characterisation of the Tumour Microenvironment in Ovarian Cancer
The tumour microenvironment comprises the non-cancerous cells present in the tumour mass (fibroblasts, endothelial, and immune cells), as well as signalling molecules and extracellular matrix. Tumour growth, invasion, metastasis, and response to therapy are influenced by the tumour …
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Folate Metabolism in Normal and Tumour Bearing Mammals
… derivatives has been studied in normal and tumour bearing rodents. Within 48 h of administration of radioactive folate tissue radioactivity was incorporated largely into high molecular weight folate conjugates. The major derivative was isolated from rat liver and identified as …
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Graph Representation Learning to Study the Tumour Microenvironment
… where cancer cells are embedded, known as the tumour microenvironment (TME). Recent technical advances allow the acquisition of highly multiplexed biomedical images (HMBI) that generate spatial tissue maps of dozens of proteins capturing the intricacies of the TME. Combining the …
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