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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"tumorigenicity"”.
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Mechanical and epigenetic regulation of cell plasticity and tumorigenicity
Made available in DSpace on 2015-09-29T21:08:15Z (GMT). No. of bitstreams: 2 SINGH-THESIS-2015.pdf: 283696 bytes, checksum: 0f7e963da95634dafa16e9e9a970da45 (MD5) LICENSE.txt: 4208 bytes, checksum: dd735d55c1189c6cc1ef21be4dc1ab2c (MD5) Previous issue date: 2015-07-22
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
An extracellular matrix (ECM) rich in fibrillar collagens is a principal component of pancreatic ductal adenocarcinoma (PDA). The ECM provides structural support for the tumor and facilitates tumor cell survival and chemoresistance by activating cell surface receptors on tumor cells. Fibrillar …
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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
<p>Glioblastoma Multiforme (GBM) is an aggressive brain tumor, characterized by high cellular heterogeneity, is refractory to treatment and has dismal prognosis. These characteristics of GBM have suggested the presence of stem-like cells that have the ability to initiate and maintain tumors of a …
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Determining how variations in cell and nuclear size contribute to mitosis and tumorigenicity in cancer cells that undergo whole genome doubling
… with cell fitness, chromosomal instability, and tumorigenicity in cancer cell lines and clinical outcome in human tumors.
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Evaluation of Chronic RalGTPase Activation as a Core Specifier of Oncogenic Transformation
… that RalA and RalB collaborate to maintain tumorigenicity through regulating both proliferation and survival. Remarkably, RalB is specifically required for survival in Ras-dependent tumor cells rather than normal cells, while RalA is required for anchorage-independent proliferation but …
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TARGETING METABOLIC PLASTICITY OF GLIOBLASTOMA TUMOR INITIATING CELLS TO RESTORE SENSITIVITY TO LSD1-DIRECTED THERAPY
… survival, stem cell-like traits and in vivo tumorigenicity of LSD1i-sensitive cells, but it exerts no effects in LSD1-resistant cells. Indeed, we measured no modifications in in vitro proliferation, even upon exposure to a prolonged treatment, survival, self-renewal and in vivo …
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Cop 9 Signalosome Subunit 6 Stabilizes Cop1, A Novel E3 Ubiquitin Ligase For 14-3-3Σ
… cell growth, transformation and promotes tumorigenicity. Significantly, 14-3-3σ expression can correct the abnormalities mediated by CSN6 expression. These data suggest that the CSN6-COP1 axis is involved in 14-3-3σ degradation, and that deregulation of this axis will promote cell growth …
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Studies of Genetic and Epigenetic Determinants of Prostate Cancer
… the forced expression of miR-101 reduces the tumorigenicity of PCa cells. These results suggest that miR-101 plays a regulatory role in PCa, and restoring its expression may be an effective therapeutic approach. In the second study, Jianfeng Xu et al. performed an Affymetrix SNP microarray …
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Tumor-like growth of mouse embryonic stem cells
… subcutaneously into NOD-SCID mice to test their tumorigenicity. The mouse ESCs maintained in standard conditions generated a well-developed tumor in 4 weeks, whereas the mouse ESCs cultured in CDSF conditions failed to form a tumor up to 6 months. When CDSF culture was supplemented with the serum …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
… EMT induces enhanced invasion, survival and tumorigenicity which can promote disease progression and recurrence after therapy. Many factors that induce EMT during development and in culture are known and these include the transcription factors Twist, Snail1/2, ZEB1/2 and goosecoid. …
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IL-2 and Antisense TGF-B1 Gene Therapy of the H238 Tumor and Analysis of TGF-B Receptors
… >2000pg/ml. Previous attempts to control H238 tumorigenicity had sub-optimal efficacies. In addition, studies had shown that the FI238 cell line was not responsive to TGF-p. This project was an attempt to develop an improved modality to reduce H238 tumorigenicity and investigate potential …
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Regulation of Hgf Expression By Δegfr-Mediated C-Met Activation In Glioblastoma Cells
… anchorage-independent colony formation and the tumorigenicity of intracranial xenografts. Building on prior findings that ∆EGFR enhanced c-Met activation, we found that ∆EGFR also led to increased HGF expression, which was reversed upon ∆EGFR inhibition with AG1478. ∆EGFR required c-Met to …
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SCRIBBLE: A POTENTIAL DUAL KINASE INHIBITOR
… activase ERK6, and its over-expression confers tumorigenicity. We hypothesized the presence of scaffolding molecules specific to ERK6, similar to other known MAP kinases. We performed yeast two-hybrid assays using ERK6 as bait, and Scribble was identified as a binding partner. Scribble contains …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
… and GBM cancer stem cells results in decreased tumorigenicity following intracranial implantation of these cells into immunocompromised mice. Collectively, these data indicate that NDRG4 does not function as a tumor suppressor like other NDRG family members, but rather it is essential for GBM …
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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
… targets that are selectively required for tumorigenicity in the presence of pathological ERK1/2 signaling. Such targets could be leveraged in jiu jitsu fashion to breach selective pressure to engage any of the many BRAF-independent ERK1/2 pathway activation mechanisms. By integration of …
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HECAT5 regulates cell proliferation via interaction with M3R in cell type-specific manner
… promotes self-renewal capacity and it enhances tumorigenicity in cell type-specific manner. HECAT5 has effects on those through the interaction with M3R (Muscarinic acetylcholine receptor 3), candidate interacting partner of HECAT5, as modulators of M3R activities regulate cell proliferation in …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… crucial roles in cell cycle progression and tumorigenicity, through regulating the expression of genes in the cellular proliferation network including the Hippo signaling pathway. Altogether, these studies support a model whereby pervasive lncRNA transcripts, previously regarded as …
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Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
… TβRIII-SS (EMT) cells exhibit decreased tumorigenicity but increased tumor growth in vitro and in vivo. These studies suggest that the balance of cell surface and soluble TβRIII may regulate a dichotomous role for TβRIII during cancer progression.</p><p>We have also demonstrated that …
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Several consequences of aneuploidy
… cancer cells. Thirdly, I compared the tumorigenicity of euploid and trisomic cell lines that were genetically-identical and differed only in karyotype. I discovered that under most circumstances, aneuploidy impeded proliferation, anchorage-independent growth, and tumor formation in …
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