Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 501 for “"tumorigenesis"”.
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Kininogen and Ferritin in Tumorigenesis
… uPAR is the most studied and most relevant to tumorigenesis. Tumor cells frequently overexpress uPAR. The work presented here focuses on the effects of HKa and ferritin on cancer cells and the signaling pathways initiated by HKa and ferritin in endothelial cells. HKa was shown to inhibit the …
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Polyclonal interactions in intestinal tumorigenesis
… lineage tracing with a mouse model of intestinal tumorigenesis to show that a significant proportion of tumours have a polyclonal origin following the loss of one allele of \textit{Apc} and subsequent mutagenesis. These polyclonal tumours cannot be explained by the random collision of independent …
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Genomic analysis of mouse tumorigenesis
… genes that are common to mouse and human tumorigenesis. Many analytic tools have emerged in recent years for human genome mining. Some of these tools have been translated to the murine versions. The work in this thesis described the application of two new whole-genome analytic techniques …
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Mouse modifiers of intestinal tumorigenesis
… gene as the pivotal event initiating intestinal tumorigenesis. Apdmin, an induced mutation in mouse homologue of APC, was identified several years ago by Moser et al., providing a genetic model system to study this process. We used the Apdmin system to identify additional genes influencing …
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MiRNA-Mediated Regulation of Colorectal Tumorigenesis
… The initiation and progression of colorectal tumorigenesis is characterized by the accumulation of genetic alterations that allow for uncontrolled gene expression and cellular responses that lead to the development of cancer. MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as …
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MicroRNAs in cellular transformation and tumorigenesis
… miRNAs might contribute to the development of tumorigenesis.
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EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide and the fourth cause of death. The major risk factors predisposing to HCC are well known although the lack of reliable markers and efficient pharmacological treatments for HCC patients remains a major problem. In the recent …
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
<p>Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyzes the trimethylation of histone H3 on lysine 27 (H3K27Me3), to repress gene transcription. Many types of cancer stem and progenitor cells, including breast, have demonstrated EZH2 to …
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EWSR1 and FUS fusion genes in tumorigenesis
… genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be identified. The sequence was found to have bidirectional activity …
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
Dysregulated Hippo pathway signaling promotes the onset of aggressive cancers through the induced nuclear activity of yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a …
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Functionality of mutant p53 in early tumorigenesis
… (p53mut/-) which is thought to promote tumorigenesis. The functionality of mutant-p53 in early tumorigenesis (p53mut/+) has been underexplored but it may uncover how the mutation primes a cell for aberrant activities. By modelling the heterozygous expression of p53R175H in unstressed, …
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Defining the role of aneuploidy throughout tumorigenesis
… We sought to elucidate aneuploidy's role in tumorigenesis by defining the factors that affect the prevalence of aneuploid cells in normal, pre-cancerous, and cancerous tissues. First, we investigated whether aneuploid mammalian cells experience fitness defects in vivo. We found that …
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Uncovering Signalling Pathways Mediating Gastrointestinal Morphogenesis and Tumorigenesis
… in gastric cancer, however, its role in tumorigenesis is unclear. By investigating the function of activated-YAP, I have shown its ability to induce gastric adenocarcinoma in a cell type-specific manner. Moreover, Yap deletion in a pre-clinical model of gastric cancer results in …
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Pten Function in Postnatal Brain Development and Tumorigenesis
<p><em>PTEN</em> (Phosphatase and Tensin homolog deleted on chromosome 10) is a tumor suppressor gene that is commonly mutated in multiple types of human cancers including endometrial, prostate, breast cancers and glioblastoma multiforme (GBM). PTEN functions as a phospholipid phosphatase …
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ELUCIDATION OF THE ROLE OF FAT10 IN TUMORIGENESIS
… that FAT10 plays an important role in tumorigenesis and cell malignancy, consistent with the reports of FAT10 overexpression in human tumor samples and we demonstrated that disruption of FAT10 and Mad2 binding significantly resulted in tumor regression and reduced cell malignancy. Our …
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
<p>Reversible acetylation has emerged as an important post-translational modification that rivals phosphorylation in regulating chromatin structure and gene expression. Acetylation of histone is associated with transcriptional activation while deacetylation is linked to transcriptional repression. …
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Investigations into the role of inflammation in tumorigenesis
… 1 opens with a broad overview of inflammation in tumorigenesis while Chapter 2 focuses on a review and discussion of current HS literature. Our investigations into the role of inflammation specifically in HS are initiated in Chapter 3 where we explore the role of the regulatory NLR, NLRX1, in the …
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Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
… in organ size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been identified as a novel oncogene that is overexpressed in non-small cell lung cancer (NSCLC) cells and mediates their proliferation, transformation and tumorigenesis. However, the molecular …
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