Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"tumor-infiltrating lymphocyte"”.
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Characterization and Optimization of Antigen-Specific T Cell Responses During Ex Vivo Expansion of Melanoma Tumor-Infiltrating Lymphocytes
Treatment of metastatic melanoma with tumor reactive T cells (adoptive T cell therapy, ACT) is a promising approach associated with a high clinical response rate. However, further optimization of this treatment modality is required to increase the clinical response after this therapy. ACT in …
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A Microfluidics-Based Approach For Isolation of Antigen-Specific Cd8+ T Cells
… patients.</p> <p> Immunotherapies that leverage tumor-specific CD8<sup>+ </sup>cytotoxic T cells have shown great promise for the treatment of NSCLC. However, although highly promising, the success of these therapies has largely been hampered by the challenge of isolating tumor-specific …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… with malignant cells in various stages of tumor development and can be polarized to two distinctive phenotypes – the pro-inflammatory M1 phenotype and the anti-inflammatory M2 phenotype. These M2 polarized tumor-associated macrophages (TAMs) are known to suppress immune responses and …
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The Association Between The Il-1 Pathway
… patients may develop an immune response to their tumors, but innate anti-tumor immune responses are insufficient for controlling the development of the tumor. Melanoma is a very immunogenic tumor, sometimes exhibiting spontaneous remissions, making it one of the foremost targets for immunotherapy. …
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BREAST CANCER DURING PREGNANCY AS A SPECIAL TYPE OF EARLY-ONSET BREAST CANCER: INSIGHTS INTO THE TUMOR MICROENVIRONMENT AND IMMUNE TRANSCRIPTOME
Breast cancer during pregnancy (PrBC) is a rare tumor with limited information on its immune landscape. Here, we sought to characterize the cellular composition of the tumor microenvironment (TME) and the immune transcriptome of PrBC to identify their differences from early-onset breast cancer …