Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"tumor xenograft"”.
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
… manner. In addition, using a human pancreatic tumor xenograft model, we show that gene delivery of CXCR2 C-tail sequence (containing the PDZ motif) by adeno-associated virus type 2 viral vector potently suppresses human pancreatic tumor growth in immunodeficient mice. In summary, our results …
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Consequences of Pathogenic Mitochondrial DNA Mutations in Cancer Progression
… by the establishment of a collection of patient tumor xenograft models with varied mtDNA status. Chapter two details the development of a new cytoplasmic hybrid (cybrid) generation method that simplifies the creation of transmitochondrial cybrids and enables transplantation of any mtDNA within …
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The Role of Oxygen and Oxygen-Dependent Enzymes in Protein Folding, Metabolism, and Redox Homeostasis
Low levels of oxygen (hypoxia) in solid tumors contributes to therapy resistance and poor patient prognosis. How the cells in the tumor microenvironment (TME) adapt to hypoxia at a transcriptional, epigenetic, and translational level has been extensively explored. Here, we provide a comprehensive …
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Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways
… ALAD, which results in proteasome inhibition and tumor cell growth suppression, suggesting that targeting this relationship is a promising approach for cancer treatment. Additionally, a series of new metal-based complexes with various metal centers, including cobalt, gold, gallium and the copper …
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Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
<p>Previous studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation …
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Sensitivity of Diffuse Reflectance Spectroscopy to Dose- and Depth-dependent Changes in Tumor Oxygenation after Radiation Therapy
… to radioresistance processes happening within a tumor on the molecular level. Radioresistance remains a big challenge for modern oncology. The ability to identify radioresistance at the early stage of radiotherapy would help physicians to improve therapy efficiency. At the current moment, despite …
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Characterizing ASCL1-Dependent Neuroendocrine Non-Small Cell Lung Cancers
… cancer, it is important to accurately classify tumors using a combination of factors, including patho-physiological features, tumor gene expression profiles, response to therapy, and oncogene/tumor suppressor mutation status. Gene expression analyses, including immunohistochemistry, single mRNA …
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Basis For Targeting Met Activation Mediated Resistance to Pi3K Inhibition In Breast Cancer
… We also analyzed DNA from 971 FFPE early breast tumors, and showed that <em>MET</em> and <em>PIK3CA</em> are frequently co-amplified, and a high copy number of either gene is associated with poorer prognostic features and the triple negative disease.(<a …
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Assembly of Highly Asymmetric Genetically-Encoded Amphiphiles for Thermally Targeted Delivery of Therapeutics
… polypeptides (CPs) to actively target drugs to tumors as conjugation to macromolecular carriers has demonstrated improved efficacy by increasing plasma retention time, reducing uptake by healthy tissues, and enhancing tumor accumulation by exploiting the leaky vasculature and impaired lymphatic …
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THE ROLE OF POU5F1B IN PROSTATE CANCER
… Here, we report that POU5F1B from prostate tumor encodes functional proteins that exhibit gene transactivation activity comparable to its parent gene, Oct4. Further, we report that POU5F1B overexpression in prostate cancer cell lines increases prostate cancer cell proliferation, migration, …
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Microfluidic Technology for Low-Input Epigenomic Analysis
… as stem cell pluripotency/differentiation and tumorigenesis. Chromatin immunoprecipitation (ChIP) is the technique of choice for examining in vivo DNA-protein interactions and has been a great tool for studying epigenetic mechanisms. However, conventional ChIP assays require millions of cells …
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The role of metabolic rewiring in endocrine resistance
… cancer specific deaths in women with ERα (+) tumor occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to prevent or delay recurrence of ERα (+) tumors. The overall objective of this dissertation project is to define the …
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Charakterisierung von Schlüsselproteinen der Signaltransduktion (EGF-R, c-erbB2, Hsp90) in humanen Tumorxenografts mittels Gewebemikroarray
… Mal beschrieben wurden. <br>Die Freiburger Xenograft-Sammlung besteht aus mehr als 350 Tumormodellen. Patiententumoren werden subkutan in Nacktmäuse implantiert und in Serienpassage etabliert. Patientendaten, wie klinische und pathologische Eigenschaften, sowie das Ansprechen der Tumoren auf …