Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"tumor tissue"”.
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Distribution and metabolism of antibodies and macromolecules in tumor tissue
Tumor targeting drugs that selectively treat cancerous tissue are promising agents for lowering the morbidity and mortality of cancer. Within this field, antibody treatments for cancer are currently being developed for both imaging and therapeutic applications. A major limitation with this class of …
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Fractal vasculature and vascular network growth modeling in normal and tumor tissue
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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A foe-inspired friend: Constructing a tumor tissue-mimicking biomaterial to study intratumoral drug transport
The design of an in vitro model of the tumor microenvironment and its implementation on drug screening of new anticancer therapies is an active challenge that sits at the interface of biomaterials and cancer biology. As recent clinical successes of human intratumoral therapies stimulate research on …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
The selective delivery of anticancer agents to tumor tissue remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and …
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The effects of dietary lipids on the fatty acid composition of tissue and membrane fractions of spontaneous mammary adenocarcinomas and mammary glands of Strong strain A mice
The fatty acid composition of whole tissue and plasma membrane fractions of mammary adenocarcinomas and normal mammary glands excised from Strong A female mice fed a 15% safflower oil and 15% tallow diets were studied. Previous work has indicated that high fat diets in general and high unsaturated …
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A study of the Project for American Studies in the Secondary Schools and its effect on curricular change
… and spermidine, on growth of crown gall tumors, to assay levels of spermidine and spermine in normal and crown gall tumor tissue and to determine the effects of selected anti-tumor compounds on growth of crown gall tumors as well as on the endogenous levels of the polyamines in those …
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Differences in miR-122 and miR-191 Expression in HBV- versus HCV-associated Hepatocellular Carcinoma
… in HBV- and HCV-associated HCC, the related non-tumor tissue, and normal liver tissue. Relative quantification of miR-122 and miR-191 in 16 HCV-associated HCC, 10 HBV-associated HCC, the respective neighboring non-tumor tissue, and 9 normal liver tissue samples was performed using RT-PCR. This …
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The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells
… (β-alanyl- L -histidine) inhibits the growth of tumor cells in vitro and in vivo. Considering carnosine for the treatment of glioblastoma, we investigated which proton-coupled oligopeptide transporters (POTs) are present in glioblastoma cells and how they contribute to the uptake of carnosine. …
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Manometric Studies of Earle's Strain L Sarcoma Cells
In his classic report, "Metabolism of Tumors" in 1925, Warburg postulated several generalizations concerning malignant tumor tissue metabolism, and summarized from his studies that "interference with the respiration in growing cells is, from the standpoint of the physiology of metabolism, the cause …
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Epitelinio kiaušidžių vėžio predikcinių imuninių žymenų paieška /
… resistance in the epithelial ovarian tumor microenvironment and peripheral blood, and to investigate the relationships among them. Objectives: to evaluate the suppressive/cytotoxic lymphocyte populations in patients peripheral blood; to measure the concentration of cytokines in tumor …
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EVALUATING SOLUBLE AXL AS A BIOMARKER FOR GLIOBLASTOMA
… determine relative AXL expression in 13 patient tumor tissue samples. Additionally, T-1 weighted MRI scans were used to interpolate pre-operative tumor volume in all participating patients. Here we report that sAXL was elevated in the 84 GBM samples compared to the 40 control samples (<em>p = …
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Expression of Vascular Endothelial Growth Factor(VEGF), Vascular Endothelial Growth Factor Receptor-1(VEGFR-1), Hypoxic Induced Factor-1alpha(HIF-1α) mRNA in Papillary Thyroid Microcarcinoma(PTMC)
PURPOSE: Angiogeneisis is essential process for tumor growth and metastasis. Vascular endothelial growth factor(VEGF) is major regulator of angiogenesis. Recently, the incidence of papillary thyroid microcarcinoma(PTMC) increased because of development in diagnostic modality. Several recent reports …
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Quantitative analysis of perivascular antibody distribution in solid tumors
… shown efficacy in a range of blood and solid tumors. Antibodies targeting solid tumors face considerable transport barriers in vivo, including blood clearance, extravasation, diffusion within the tumor interstitium, binding to antigen, endocytosis, and degradation. The unique pathology of the …
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Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
… minimization of drug exposure to healthy tissues and concentration of the drug within the tumor. As such, encapsulation of chemotherapeutic agents inside nanoparticles capable of enhancing tumor-targeted drug delivery is a particularly promising innovation. Yet, initial investigations into …
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Detection and monitoring of treatment resistance in metastatic cancer through non-invasive DNA methylation-based biomarkers
… work focuses on empowering plasma circulating tumor DNA (ctDNA) analysis, as a non-invasive approach for precision oncology, with applications ranging from early detection and minimal residual disease (MRD) assessment to dynamic monitoring of treatment response and molecular profiling in …
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A synthesis of a homologous series of aryl mono- and diboronic acids
… esters which show a preferential affinity for tumor tissues for use in radiation therapy of neoplatic disorders (1,2). The data of Soloway, as extended and refined by Hansch and his coworkers, successfully correlates the low lipid solubility and electron releasing substituents of phyenl boronic …
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NANO-PARTICULATE DRUG CARRIERS FOR EFFECTIVE TARGETING AND DRUG DELIVERY TO BLADDER TUMORS
… of specificity of drugs/drug carriers for the tumors and the short residence time of the instilled agent in the bladder due to urine voiding. To address these challenges, albumin-based carriers in two forms i.e., native albumin chains (~16nm) and albumin nanoparticles (HNP ~100nm), both …
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Angiotensin-(1-7) Reduces Prostate Cancer Growth and Metastasis by Altering the Tumor Microenvironment
… that is produced in the circulation and in tissues by proteolytic cleavage of angiotensin I or II. The heptapeptide mediates biological responses by activating a unique G-protein-coupled angiotensin-(1-7) [AT(1-7)] receptor mas, thereby providing specific targeted actions when used as a …
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Protoporphyrin IX distribution in rat brain following the administration of 5-aminolevulinic acid and its hexylester
… and development of glioblastoma multiforme tumors in vivo, Rowett nude rats were injected with the maximum tolerable ALA or h-ALA dose. Animals were sacrificed four hours post-injection and intact brains were removed. Fluorescence microscopy was performed to quantify PpIX production. Results …
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… to produce a diffuse photon density wave in the tissue. The phase of the diffuse photon density wave is measured by comparing the reference signal with the signal from tissue by using a phasemeter. In parallel, we have developed and evaluated fluorescent Alexa Fluor 680 and Alexa Fluor …
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