Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"tumor therapy"”.
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A novel nanodelivery system for combination tumor therapy
Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in inducing tumor regression in the clinic due to both the cytostatic nature of …
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Liposome-anchored local delivery of immunomodulatory agents for tumor therapy
… the immunosuppression present in advanced tumors. Agonistic antibodies against the co-stimulatory receptors CD40 and CD137, Toll-Like Receptor (TLR) ligands such as CpG oligonucleotides, and immunostimulatory cytokines such as IL-2 have all previously demonstrated potent, synergistic …
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Development and characterization of anti-EGFR protein-drug conjugates for tumor therapy
… combine the ability of an antibody to target tumor-specific antigens with the cell-killing potential of a cytotoxic payload after cellular internalization. The epidermal growth factor receptor (EGFR) is a validated tumor marker overexpressed in various cancers such as squamous cell carcinoma …
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A comparison of three gadolinium based approaches to cancer therapy
Some recent neutron capture therapy (NCT) research has focused on using compounds containing the element gadolinium (Gd), which produces internal conversion and Auger cascade electrons upon absorbing thermal neutrons. The low energy, nanometer-range, Auger electrons are absorbed locally and …
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The Effects of Levamisole, CORYNEBACTERIUM PARVUM, and Unblocked Lymphocytes on Mice Injected with Herpes Virus Type 2-transformed Cells
… were used as negative controls and received no tumor cell injection. All other groups received subcutaneous injections of 1 x 10<sup>6</sup> cells/ mouse. Tumor therapy by means of irrmunostimulation was started for each group of mice 1 day after the initial tumor cell injection and proceeded on …
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Comparing water to DNA for simulation of Auger electron direct damage to DNA using Geant4
… nano scale. The increased interest in targeted tumor therapy using Auger electrons has requires an understand of the radiobological effectiveness of low energy electrons. A chromatin ber was constructed within the Geant4 simulation toolkit down to the molecular level. The Binary Encounter Bethe …
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A novel function of tissue inhibitor of metalloproteinase-1 as a chemoattract molecule for neural stem cells
… to migrate to damaged brain area, such as brain tumor or ischemic region. So, we hypothesized that human glioma or ischemic tissues secreted chomoattract molecules that induce NSC migration toward that area. In present study, we reported one candidate protein, TIMP-1, commonly expressed from …
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Design and development of an RNA vaccine against tumor-mediated angiogenesis and metastasis targeting a KLH-Adrenomedullin fusion protein
… response. AM is overexpressed by most solid tumors, which makes it a good target for anti-tumor therapy. In this study, we designed and tested a mRNA vaccine directed against a fusion antigen composed by a small piece of keyhole limpet hemocyanin (KLH), as a hapten, and mouse AM. The in …
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A Novel System and Image Processing for Improving 3D Ultrasound-guided Interventional Cancer Procedures
… Interventional approaches, such as biopsy, brachytherapy, and ablation procedures, have been used in the management of cancer for many anatomical regions, including the prostate and liver. Needles and needle-like tools are often used for achieving planned clinical outcomes, but the increased …
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Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… to these malignant cells participates in tumorigenesis and is required for the tumor to advance past the hyperplastic stage. Angiogenesis, or expansion of the existing vascular network, is required for the growth of solid tumors. For this reason, tumor angiogenesis is an attractive target …
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Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
… cell exhaustion is a major barrier limiting anti-tumor therapy. Though checkpoint blockade temporarily improves exhausted CD8 T cell (Tex) function, the underlying epigenetic landscape of Tex remains largely unchanged, preventing their durable “reinvigoration.” Whereas the transcription factor …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… as a) single agents with combination chemotherapy potential having dual antiangiogenic effects and cytotoxic effects or b) one-carbon metabolism inhibitors for targeted tumor therapy; or c) selective <em>Pneumocystis jirovecii </em>(pj)<em> </em>dihydrofolate reductase (pjDHFR) inhibitors …
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DUPA α-Amanitin Conjugates for Targeted Prostate Cancer Therapy - Optimization and Evaluation of In Vivo Potency
… the main limitations in the use of ADCs in solid tumor therapy seems to be restrained tumor penetration due to the high molecular size of this class of therapeutics. In this work a library of small molecule drug conjugates (SMDCs) as an alternative for large molecular ADCs was developed and tested …
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Studien zur Entwicklung eines prädiktiven Chemosensitivitätstests mit Mikrosensoren
… die mittlere Überlebenszeit von Tumorpatienten verlängern können. Dennoch finden sie bisher kaum klinische Anwendung. Im Gegensatz zu herkömmlichen auf empirischen Daten basierenden Therapieschemata individualisieren sie die Chemotherapie, ermöglichen so eine evidenzbasierte …
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PRECLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION OF NEW ANTICANCER AGENTS FOR BRAIN TUMOR CHEMOTHERAPY
… (GBM) is the most common malignant primary brain tumor in adults for which overall prognosis remains poor despite recent treatment advances, thus emphasizing the need for developing effective therapeutic agents. Styryl sulfones belong to a class of non-ATP competitive antineoplastic agents in …
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… most intracellular pathogens (e.g., HIV) and tumors require functional CTL immunity and are ineffectively treated by antibodies or humoral immunity. Traditional needle-based vaccination strategies primarily induce humoral immunity and are inefficient at eliciting robust CTL responses using …
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Comparison of the therapeutic efficacy of SNAP-tag fusion protein and the synergistic actions of chemotherapy and photodynamic therapy in killing resistant melanoma
… surgical excision of primary nonmetastatic tumor remains the gold standard of therapy worldwide. Upon metastases, melanoma becomes highly resistant to conventional radio-and chemotherapy. Chemotherapy, using dacarbazine (DTIC), remains the standard treatment option. In melanoma, chemotherapy …
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Irreversible Electroporation Therapy for the Treatment of Spontaneous Tumors in Cancer Patients
… technique for diseased tissues, including tumors. IRE electric pulses may be delivered through small (ø ≈ 1 mm) needle electrodes, making treatments minimally invasive and easy to apply. There is sub-millimeter demarcation between treated and unaffected cells, which may be correlated with …
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Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide and Tumor Escape
… to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted the transfer of the CAR-cognate-antigen from tumor to NK cells, resulting in (1) lower tumor antigen density, thus …
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