Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"tumor suppressor gene"”.
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Functional analysis of the Neurofibromatosis Type II tumor suppressor gene
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Mutagenesis of the p̳53 tumor suppressor gene studied in Saccharomyces cerevisiae
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
… to transform normal cells into cancerous tumors. Additional driver mutations or epigenetic alterations are required to cooperate with the activating Ras mutations in tumorigenesis. In C. elegans, worms homozygous for activated Ras mutations have 60 - 80% penetrant visible multivulval (Muv) …
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Aberrations of A Putative Tumor Suppressor Gene Sel1L In Pancreatic Ductal Adenocarcinoma
… </em>(<em>SEL1L</em>) is a putative tumor suppressor gene that is downregulated in a significant proportion of human pancreatic ductal adenocarcinoma (PDAC). It was hypothesized that <em>SEL1L</em> expression could be down-modulated by somatic mutation, loss of heterozygosity (LOH), …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the disease and thus design more suitable therapeutic options. Neurofibromatosis Type 2 (NF2) is …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the disease and thus design more suitable therapeutic options. Neurofibromatosis Type 2 (NF2) is …
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A New Tumor Suppressor Gene Candidate Regulated By The Non-Coding Rna Pca3 In Human Prostate Cancer
… progression still remain elusive. The study of tumor biomarkers, due to their specific altered expression in tumor versus normal tissue, is a valid tool for elucidating key aspects of cancer biology, and may provide important insights into the molecular mechanisms underlining the tumorigenesis …
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Analysis of the Transcriptional Regulation and Bidirectional Nature Of the Promoter of the p53 Tumor Suppressor Gene
<p>p53 is a tumor suppressor protein that plays a role in many cellular processes ranging from cell cycle regulation to apoptosis. The protein's role as a transcription factor has shown that deregulated transcription, whether increased (as with mutant p53 transcription) or decreased (failure to …
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Creating a mouse model of neurofibromatosis type I : pathological and functional analysis of a tumor suppressor gene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Analysis of the function of the Nf2 tumor suppressor protein, Merlin
The Neurofibromatosis type 2 tumor suppressor gene (NF2) is mutated in inherited and sporadically occurring central nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal domain to members of the band 4.1 family of membrane-cytoskeletal …
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Downregulation of Pax2 Suppresses Ovarian Cancer Cell Growth
<p><em>PAX2</em> is one of nine <em>PAX</em> genes regulating tissue development and cellular differentiation in embryos. <em>PAX2</em> promotes cell proliferation, oncogenic transformation, cell-lineage specification, migration, and survival. Unattenuated <em>PAX2</em> has been found in several …
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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
… CDK9 is also essential for maintaining gene silencing at heterochromatic loci. Through a live cell screen, we discovered that CDK9 inhibition reactivates epigenetically silenced genes in cancer, leading to restored tumor suppressor gene expression and cell differentiation, along with …
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RNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA
… INVESTIGATED THE REGULATIONS OF ADARS ON TARGET GENES WITH EXTENSIVE 3?UTR EDITING. USING RNA-SEQ AND LUCIFERASE REPORTER ASSAYS, WE IDENTIFIED A NOVEL TUMOR SUPPRESSOR GENE METTL7A (METHYLTRANSFERASE LIKE 7A) AS A BONA FIDE 3?UTR EDITING TARGET OF ADARS. HCC PATIENTS WITH LOWER METTL7A …
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Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells
… by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor …
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EARLY GROWTH RESPONSE 1 (EGR1) AS A TUMOR SUPPRESSOR AND APOPTOSIS INDUCER IN RHABDOMYOSARCOMA
EGR1, one of the immediate-early response genes, plays an important role as a mediator for transmitting extracellular stimuli. EGR1 is down regulated in many cancers. Many studies show that it functions as a tumor suppressor gene in a variety of cancers. EGR1 also acts as an oncogene in number of …
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A cancer screen in zebrafish identifies many ribosomal proteins as haploinsufficient tumor suppressors
… displayed early mortality and externally visible tumors. Among such tumor-prone lines identified was one in which the known human tumor suppressor gene, neurofibromatosis type 2 (NF2), was mutated. This validated the screening approach, as well as confirmed the human relevance of the zebrafish …
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Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology
… cancer, is associated with mutated PTEN tumor suppressor gene. The type I endometrial cancer PTEN hotspot mutation involves a cytosine to guanine transversion. The mechanism for C to G transversions in endometrial tissue has not been previously explained. For the first time, we show that …
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Detection of Single Nucleotide Polymorphisms In Csmd1 Gene of Colon and Breast Cancer Patients
<p>CSMD1 is a candidate tumor suppressor gene that maps to chromosome 8p23 that codes for a novel multiple domain complement regulatory and adhesion protein. To determine whether mutations in CSMD1 affected tumor development or patient outcome, we used nucleotide sequencing to identify single …
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TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using …
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TIS21 inhibits cell migration and invasion
TIS21/BTG2/PC3 is tumor suppressor gene and frequently downregulated in cancer tissue. In human tissue, decreased BTG2 is correlated with cancer cell metastasis, suggesting that suppression of BTG2 has a critical role in cancer cell migration and invasion. When we overexpressed TIS21 in A549 cells, …
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