Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 59 for “"tumor suppression"”.
-
Tumor Suppression by a TRNA Synthetase
… healthy mammary cells must bypass tumor suppressive checkpoints and activate pro-growth pathways. Enhanced protein translation is one such hallmark of tumor transformation and cancer progression; many oncogenes promote translation by driving synthesis and activity of translational …
-
Cooperative Tumor Suppression by ARF and p53
… disease characterized by the inactivation of tumor suppressor genes and enhanced activity of oncogenes leading to deregulated cellular proliferation. Two tumor suppressor genes, p53 and Arf, play important roles in protecting cells against numerous biological stresses. In response to oncogenic …
-
The retinoblastoma gene family in tumor suppression and development
The retinoblastoma tumor suppressor and the closely related p107 and p130 proteins play important roles in the regulation of both tumorigenesis and tissue-specific differentiation. To determine the role of Rb in development more precisely, we analyzed chimeric embryos and adults made with marked …
-
The role of NK cells in selectin-dependent tumor suppression
… that, in the absence of selectins, human tumors transplanted subcutaneously into Rag2'- mice grow significantly larger. This implicates selectins and the innate immune system in tumor immune surveillance. We have extended the xenograft tumor model to immunocompetent C57BL/6 mice. Similarly …
-
Secreted Factors from CD36+ Fibroblasts Induce Tumor Suppression in Subtypes of Breast Cancer
… mechanisms. To inhibit or potentially reverse tumor growth, our goal is to emulate this signaling and reprogram the microenvironment. For example, in a healthy mammary gland, fibroblasts (FBs) overexpress CD36; the downregulation of CD36 is one of the hallmarks of cancer-associated FBs. …
-
Germline HOXB13 G84E Mutation Inhibits MEIS1-HOXB13 Driven Tumor Suppression in Prostate Cancer
… on HOXB13 was studied in the context of HOXB13’s tumor suppressive co-transcription factor, MEIS1, yielding dysregulation of proteoglycans consistent with a loss-of-function HOXB13 status. The G84E mutation resulted in faster onset and progression of 22Rv1 tumor xenografts in SCID mice and were …
-
E2F1 and Tumor Suppression: The Role of P21, Mirnas, and The Dna Damage Response
… (DDR). Moreover, E2F1 has opposing roles in tumor development, acting as either a tumor suppressor or an oncogene depending on the context. In human cancer, E2F1 is often deregulated through aberrations in the Rb-p16INK4a-cyclin D1 pathway. In these studies we examined three mechanisms by …
-
The Role of Autophagy in Early Development and Tumor Suppression Using a Zebrafish Model System
… important roles for autophagy in development and tumorigenesis have been suggested. Genetic analyses indicate that autophagy is essential for eukaryotic differentiation and development. However, little is known about whether autophagy contributes to morphogenesis during embryonic development. To …
-
Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… is known to be an active contributor to tumorigenesis, rather than being a by-product of malignant progression. The retinoblastoma protein (pRB) is the prototypic tumor suppressor. Its tumor suppressive properties are linked to its ability to negatively regulate proliferation by …
-
P53 Dimers Elicit Unique Tumor Suppressive Activities Through An Altered Metabolic Program
<p>p53 is the most frequently mutated tumor suppressor in human cancer. As a tetrameric transcription factor, mutation of the p53 Tetramerization Domain (TD) is a mechanism by which cancers abrogate wild-type (WT) p53 function. p53 TD mutations result in a protein that preferentially forms monomers …
-
Genetic Analysis of The Hippo Pathway In Mouse Liver
<p>Cancer therapy and tumor treatment remain unsolved puzzles. Genetic screening for tumor suppressor genes in <em>Drosophila</em> revealed the Hippo-signaling pathway as a kinase cascade consisting of five core components. Disrupting the pathway by deleting the main component genes breaks the …
-
Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
… p53, both p63 and p73 have been shown to mediate tumor suppression in multiple tissue types. Interestingly, however, both genes are expressed as multiple isoforms, which appear to have different and, in many cases, antagonistic functions. Through the use of isoform-specific null alleles of p63 and …
-
Rmi1 Is Essential For Early Embryonic Development and Attenuation of Tumor Development
… double-heterzygous mice showed shortened tumor latency and aggressive tumor types when comparing with wild type, RMI1+/- and p53+/- control cohorts. My study suggests a dual-functional role of RMI1 in early embryonic development and tumor suppression.
-
Tissue-specific interactions between oncogenic K-ras and the p19A̳r̳f̳_p53 pathway determine susceptibility to transformation
Tumor development is a multi-step process driven by the collective action of gain-of-function mutations in oncogenes and loss-of-function alterations in tumor suppressor genes. The particular spectrum of mutations in a given cancer is rarely the result of random chance but instead derives from the …
-
Axl RTK and microRNAs in urogenital cancers
… which were measured in a cohort of 198 RCC tumors. Importantly, we identified a 2-microRNA ratio, miR(21/10b), which is an independent prognostic factor in metastasis-free ccRCC patients. These microRNAs are both linked to chronic kidney disease, a risk factor for ccRCC, and could …
-
THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… the Arf promoter. It is also a bona fide tumor suppressor that is activated by oncogenic Ras and HER2 signalings and in turn stimulates the Arf-p53 tumor suppression pathway. Dmp1 physically interacts with cyclin D1 that is frequently overexpressed in breast cancer. Cyclin D1 can either …
-
The Tumor-Suppressive Properties of Neural Stem Cells
… system malignancy that commonly causes immune suppression in patients to avoid immune recognition and clearance. This complicates treatment options and limits the effectiveness of immunotherapy strategies. Interestingly, GBM formation can stimulate the neurogenic subventricular zone of the …
-
TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using …
-
Novel Oligomeric Fluoropyrimidines and Their Efficacy for the Treatment of Colorectal Carcinoma Independent of p53 Mutation
… 5-FU displays towards normal p53 function, a tumor suppressor protein that is commonly mutated in advanced CRC. In addition to the relatively low success rate of 5-FU in aggressive CRC, 5-FU treatment also causes systemic toxicity, particularly to the GI-tract. The presented studies aimed to …
-
The Novel Purification and Biophysical Characterization of CXC Chemokines
… diseases such as tissue damage or sun burn, tumor suppression and regulation, and obesity from insulin resistance. In particular, the CXC family of chemokines are active as monomers, homodimers, and heterodimers, with binding affinities for multiple CXC G-protein-coupled receptors. This …
Page 1 of 3