NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 30 for “"tumor stroma"”.

  1. Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology

    Hintz, Hallie2021

    … fibroblasts (CAFs) and localization to the tumor microenvironment. Here we document the discovery and validation of a monoclonal antibody that selectively binds to FAP. The lead antibody, B12, was identified from a naïve murine single-chain variable fragment antibody phage display library …

    umn Repository record

  2. The Biomechanical Role of Cancer-Associated Fibroblasts In Tumor-Stroma Reciprocity

    Massengill, Nathan Wasson

    … stimuli have been found to influence tumor cell proliferation and metastasis with increased stiffening of the extracellular matrix being a hallmark of tumorigenesis. This thesis examines the role of the extracellular environment surrounding tumors, the tumor stroma, and investigates …

    south-carolina Repository record

  3. Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma

    Lo, Albert2016

    … epithelial tissues and a desmoplastic stroma formed by accumulation of hematopoietic cells, mesenchymal stromal cells and extracellular matrix. The crosstalk between malignant epithelial cells and tumor stroma is becoming increasingly appreciated as a key determinant in tumor …

    penn Repository record

  4. Development of Microfluidic 3D Cell Array with Tumor-Stroma interaction for Cancer Immunotherapy Drug Screening

    Chi, Chun-Wei2026

    … some breast cancer subtypes that the presence of tumor infiltrated lymphocytes correlates patients’ survival rate, especially for TNBC patients. In addition, the immune checkpoint ligands, PD-L1, is upregulated in 30-50% of all the breast cancer subtypes. Atezolizumab and pembrolizumab, two …

    cuny Repository record

  5. Elucidating The Role of Cd44 Expression On Mesenchymal Stem Cells Within The Tumor Microenvironment

    Spaeth, Erika L2011

    The tumor microenvironment is comprised of a vast array of heterogeneous cells including both normal and neoplastic cells. The tumor stroma recruitment process has been exploited for an effective gene delivery technique using bone marrow derived MSC. Targeted migration of the MSC toward the tumor …

    uthsc Repository record

  6. The impact of Wnt5a signaling and tumor associated macrophages in breast cancer

    Hagerling, CatharinaDepartment of Laboratory Medicine, Lund University2012

    … death for women with breast cancer is secondary tumors. Downregulation of Wnt5a in primary ductal breast cancer has been correlated with poor outcome and higher tumor grade and found to be an independent predictor of recurrence. The ability of Wnt5a to inhibit tumor progression can partly be …

    lund Repository record

  7. Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma

    Li, YuankeUniversity of Missouri--Kansas City2020

    Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass, which acts as a barrier that impedes the delivery of antitumor drugs into the tumor microenvironment and reduces the therapeutic efficacy. The objective of …

    umkc Repository record

  8. An examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumors

    Zachariah, RoshiniBoston University2013

    … (EMT) and cancer stem cells (CSC) in solid tumors. Epithelial to mesenchymal transition describes the conversion of cancer cells from an adherent, differentiated, and polar phenotype (epithelial) to a motile, plastic, and apolar phenotype (mesenchymal). EMT is correlated with metastasis; EMT …

    bu Repository record

  9. Analysis of Cancer Margins in Mass Spectrometry Images

    Katherine Williams2024

    … analysis of metabolite activity surrounding a tumor border could enhance intraoperative tumor resection. One method to collect this data is mass spectrometry imaging, an analytical technique that can detect the patterns of metabolites within a sample and retain the spatial information. The …

    queens Repository record

  10. Immunhistologische Charakterisierung immunkompetenter Zellen in Plattenepithelkarzinomen des oberen Aerodigestivtraktes

    Bittner, ThomasUniversität Würzburg

    … wurde bezogen auf den Differenzierungsgrad des Tumors, definiert durch die Ausprägung der Basalmembran. Epithel und Stroma wurden getrennt ausgezählt. Der Verlust der Basalmembran wurde von einer Veränderung in der Zusammensetzung des Immunzelleninfiltrates begleitet: HLA-DR und LFA nahm in …

    wurz-thes Repository record

  11. Correlation Matrix Analysis Identifies Gene Signatures of Immune Cell Subsets and Their Interactions In Follicular Lymphoma

    Westin, Jason R.2015

    … analysis (CMA) of publicly available FL whole-tumor gene expression profiling (GEP) data, we have identified signatures of immune cell subsets. Overall survival correlated most highly with a model using signatures of macrophages, T cells, and stroma, which was able to add significantly to …

    uthsc Repository record

  12. Influence of Fibroblasts on Metastatic Cancer Cell Drug Resistance in a 3D Microfluidic Cell Array

    Benoy, Elizabeth C2017

    <p>Modeling an accurate depiction of the tumor microenvironment, (TME), is essential to observe the effect external factors might have on the tumor <em>in vivo.</em> In cancer therapy specifically, the outcomes of clinical treatments are heavily dependent on drug testing methods despite the …

    cuny Repository record

  13. Interaktionen von humanen mesenchymalen Stromazellen (hMSC) mit Plattenepithelkarzinomzellen des Oropharynx in indirekter Kokultur

    Fricke, Martin Dr.2012

    Maligne Tumorzellen interagieren auf vielfältige Weise mit dem benachbarten Tumorstroma mesenchymalen Ursprungs, wodurch grundlegende Eigenschaften hinsichtlich Invasivität und Metastasierungsverhalten gesteuert werden können. So wird z.B. bei hepatozellulären Karzinomen oder bei Zellen der …

    goettingen Repository record

  14. Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis

    Bergenfelz, CarolineDepartment of Laboratory Medicine, Lund University2014

    … one hand, the immune system protects us against tumor development by recognizing and eliminating cancerous cells. On the other hand, tumor-associated immune cells can contribute to tumor progression by secreting growth factors as well as immunosuppressive, pro-angiogenic and/or pro-metastatic …

    lund Repository record

  15. Myeloma-osteoclast interactions as a therapeutic target for multiple myeloma bone disease

    Roosma, Justin

    … promote osteoclastogenesis by re-educating the tumor stroma to increase expression of RANKL. Using in vitro models, we investigated the influences of multiple myeloma on the differentiation of osteoclasts and discovered divergence in the effect of the human multiple myeloma cell line, MM.1S, on …

    eastern-wash Repository record

  16. Development of a High-Throughput 3D Tumor Model for Bone Sarcomas

    Santoro, MarcoRice University2016

    … complexity of the native three-dimensional (3D) tumor microenvironment, resulting in a lack of correspondence between preclinical data and clinical trial outcomes. The establishment of high-throughput 3D models able to describe distinctive aspects of the tumor niche would advance our …

    rice Repository record

  17. Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor

    Hsu, Heng-Wei

    <p>Tumor angiogenesis is a hallmark of advanced cancers and promotes invasion and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for …

    loma-linda Repository record

  18. ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS

    BARZAGHI, BIANCAUniversità degli Studi di Milano2025

    … malignancy characterized by marked inter-/intra-tumor variability and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor and stromal cell behavior, promoting metastasis and driving therapy resistance. …

    milano Repository record

  19. RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression

    Morrow, Brittany, Morrow, Brittany A, <p>0000-0002-2124-8019</p>2024

    … to be a clinically effective strategy to enhance tumor specific immune responses. Recently discovered novel immunoglobulin superfamily ligand V-domain Ig suppressor of T-cell Activation (VISTA) is a new target for immunotherapy. VISTA expression is specifically upregulated on tumor infiltrating …

    uthsc Repository record

  20. Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma

    Zhang, Ying Zhang2016

    … commonly fails due to the immunosuppressive tumor microenvironment (TME). The aim of my dissertation is to develop strategies that dampen the TME’s immunosuppressive capacity and improve the antitumor performance of vaccine-induced melanoma-associated antigen (MAA)-specific CD8+T cells. I …

    penn Repository record

Page 1 of 2