Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"tumor recurrence"”.
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Blood Neutrophil-to-Lymphocyte Ratio predicts tumor recurrence in patients with hepatocellular carcinoma within Milan criteria after hepatectomy
… evaluate whether NLR could predict the risk of recurrence and death for the HCC patient confirming to Milan criteria after hepatectomy. Methods: Retrospective analysis was performed on a database of HCC patients who underwent hepatectomy between March 2001 and December 2011. The cutoff value of …
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… were associated with poor OS. In the analysis of tumor recurrence, 514 genomic regions with CNAs were associated with recurrence. Integrative analysis revealed that the overexpression of 16 genes including FGR (P=0.003), RELA (P=0.049), LTBP3 (P=0.050), and RIN1 (P=0.023) were significantly …
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Nuclear Basic Fibroblast Growth Factor Regulation of Triple-Negative Breast Cancer Dormancy/Recurrence
… within three years of treatment due to recurrent tumor growth. Developing ex vivo models for TN breast cancer recurrence and defining responsible molecules will be crucial to developing effective combination therapies for TN breast cancer patients. We have developed an in vitro model of TN breast …
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Novel Prognostic Markers and Therapeutic Targets for Glioblastoma
… is the most common and lethal malignant brain tumor with a survival rate of 14.6 months and a tumor recurrence rate of ninety percent. Two key causes for glioblastomas grim outcome derive from the lack of applicable prognostic markers and effective therapeutic targets. By employing a loss of …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
<p>Tumor recurrence following initial treatment is the leading cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression and to facilitate appropriate responses to environmental cues. However, it is increasingly appreciated that epigenetic …
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Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
… of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the expression patterns of XIAP in various neoplastic thyroid disorders and determine the association …
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Local exposure and efficacy of a reservoir-based drug delivery device
Prognoses for primary or metastatic brain tumor patients have been poor, despite developments in treatment over the last twenty years. 14,000 people die each year from glioblastoma multiforme (GBM). 200,000 new cases of breast cancer are diagnosed each year, with 15% of those patients experiencing …
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A histological and immunological response study of an implantable microcapsule drug delivery device for the treatment of glioblastoma
… (GBM) and the more prevalent metastatic brain tumor are some of the most deadly forms of cancer, accounting for the death of nearly 14,000 individuals yearly. Previous treatment options for brain cancers include tumor resection, radiation, and chemo therapy but such options provide limited …
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
Malignant brain tumors such as gliomas can arise from a subpopulation of cells frequently called glioma stem cells (GSCs). These cells are often resistant to conventional therapies, hence are the likely culprits of tumor recurrence. Here, we describe the derivation of a human GSC line, NNI-8. Our …
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Novel Approaches in Pancreatic Cancer Treatment: Bridging Mechanics, Cells, and Immunity
… (IRE), a cutting-edge non-thermal tumor ablation technique. This study demonstrates IRE-mediated ability to trigger programmed necrotic cell death, induce cell cycle arrest, and modulate immune cell populations within the tumor microenvironment. This transformation from a pro-tumor …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
The process of tumor metastasis is often enabled by the epithelial-mesenchymal transition (EMT), a key developmental program that is often activated during cancer invasion and metastasis. During the EMT process, cells undergo phenotypic changes, lose of E-cadherin expression and acquire invasive …
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Locally Administered Particle-Anchored Cytokines Safely Enhance Cancer Immunotherapy
… been proposed as a powerful approach to curing tumors, based on the natural function of the immune system in protecting its host with specificity, thus holding the potential for developing long-term memory that prevents tumor recurrence. However, the immunosuppressive feature of the tumor …
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High Throughput Screening for Small Molecule Interactions with Nucleic Acid Binding Proteins
… metastasis, as well as treatment resistance and tumor recurrence. Our ability to manipulate these entities in cells, and therefore our ability to understand their function precisely or to intervene in pathological processes, is extremely limited without genetic manipulation. To address this …
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CYTOKINE CONTROL OF GLIOMA ADHESION AND MIGRATION
… the most lethal primary central nervous system tumor, with median survival after diagnosis of less than 12 months because dissemination into the brain parenchyma limits the long-term effectiveness of surgical resection, and because GBM cells are resistant to radiation and chemotherapy. This sad …
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Treatment of enchondroma of hand using calcium sulfate and autobone grafting
… such as delayed union, nonunion, infection, or tumor recurrence in both groups. CONCLUSION: The use of injectable calcium sulfate avoids donor-site morbidity of the auto-bone grafting has no difference in result comparing with autograft. It appears as a safe and effective bone substitute for the …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… roughly 40% of patients exhibit no response, tumor recurrence or tumor progression following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to BCG standard of …
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Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells
… carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I utilized two distinct methods of E-cadherin inhibition that distinguish …
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Inhibition of biofilm growth on highly polycationic polyelectrolyte multilayers
… carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I utilized two distinct methods of E-cadherin inhibition that distinguish …
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Radiation therapy of pediatric brain tumors : comparison of long-term health effects and costs between proton therapy and IMRT
… is an important component of pediatric brain tumor treatment. However, radiation-induced damage can lead to adverse long-term health effects. Proton therapy has the ability to reduce the dose delivered to healthy tissue when compared to photon radiation therapy, but this dose benefit comes at …
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Examining location-specific invasive patterns: linking interstitial fluid and vasculature in glioblastoma
… is the most common and deadly primary brain tumor with an average survival of 15 months following diagnosis. Characterized as highly infiltrative with diffuse tumor margins, complete resection and annihilation of tumor cells is impossible following current standard of care therapies. Thus, …
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