Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"tumor promotion"”.
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Targeting Akt/Mtor Signaling Pathways During Murine Skin Tumor Promotion and The Impact of Dietary Energy Balance Manipulation
… across a broad range of species and tumor types. Previous data has demonstrated differential signaling through Akt and mTOR via the IGF-1R and other growth factor receptors across the diet-induced obesity (DIO)/CR spectrum. Furthermore, mTORC1 is known to be regulated directly via …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… human cancers and murine mouse models of tumorigenesis. Previous studies from our lab and others have established a critical role for Stat3 in epithelial tumorigenesis, but the role of Stat1 is largely unknown. The current study was designed to explore the role of Stat1 during multistage …
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Regulation of Hepatic Detoxification Enzymes by Glucosinolate Breakdown Products in Cruciferous Vegetables
… breakdown products studied here also have anti-promotional effects through inhibition of AP-1 induced tumor promotion in vitro.
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Structure-Activity Relationship and Mechanistic Studies on the Chemopreventive Activity of Dipyridamole and Its Analogues
… activity against JB6 P<sup>+</sup>cells (tumor promotion sensitive). To probe the effects of <strong>DPM</strong> structural features on its antitumor promotion activity, the soft-agar colony forming efficiency assay was used to screen an in-house library of structurally varied novel …
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Toward the design, synthesis and evaluation of Protein Kinase C inhibitors
… plays critical roles in cell differentiation, tumor promotion, oncogenesis and cell regulatory processes. The primary driving force of this project was the study and development of enantioselective PKC inhibitors. To accomplish this objective the four stereoisomers, (2S/4S)-, (2RI4S)-, …
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The Enantiospecific Total Syntheses of Adda and Nodularin
… to elucidate roles of protein phosphatases in tumor promotion or suppression.
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The Role of Peroxiredixin Ⅲ in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cell
… neurodegenerative disorders, as well as to tumor promotion. Normal cellular processes that involves oxygen result in the production of reactive oxygen species. Intracellular H2O2 is removed mostly by catalase, glutathione peroxidase, and peroxiredoxin(Prx). The newly identified Prx family of …
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Role of Il-17/Il-17Ra Signaling In The Pancreatic Tumor Microenvironment
… of a highly immunosuppressive fibro-cellular tumor microenvironment (TME). Our research has revealed the important role of IL-17 in the development and progression of pancreatic cancer, yet the specific cellular compartment responsible for IL-17-mediated tumor promotion remains unknown. We …
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
… bile acids have been shown to promote intestinal tumorigenesis in rodent models. Since high fat diet is considered a major risk factor for colorectal cancer (CRC), and is associated with increased bile acid concentrations in the colon, it has been proposed that bile acids contribute to the …
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Beteiligung der Gene E6 und E7 des Mastomys natalensis Papillomvirus an der Entstehung von Hauttumoren in transgenen Mäusen
… werden, daß sie bei der Entstehung von malignen Tumoren der Haut beteiligt sind. Jedoch wurden bei Patienten mit Epidermodysplasia verruciformis spezifische kutane HPV-Typen in malignen Tumoren nachgewiesen. Die vorliegende Arbeit untersucht die Beteiligung der E6- und E7-Onkoproteine des kutanen …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… wound-like microenvironment that explained the tumor promotion seen in the absence of Notch1 in the skin. Therefore, skin carcinogenesis is a non-cell autonomous consequence of Notch deletion in keratinocytes, which represents the end result of a crosstalk between barrier-defective epidermis and …
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The use of cultured cells with defects of citrulline metabolism in diagnosis and in the study of intercellular communication
… divalent cations on junctional communication. Tumor promoters such as phorbol esters and organochlorine pesticides have been reported to inhibit intercellular junctional communication in other systems, and this inhibitory activity may be related to the mechanism of tumor promotion. The …
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Carbonate Ions and Gastric Cancer
… models in attempts to generate gastric tumors in these animals. In the first study underlying this thesis, rats were subjected to gastric resection to generate duodenogastric reflux (DGR) and subsequent development of gastric adenocarcinomas. The effects of various food supplements on …