Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 301 for “"tumor progression"”.
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Role of Phosphorylated Dicer1 In Tumor Progression
… DICER1 functions as a haploinsufficient tumor suppressor which regulates miRNAs and Epithelial-to-Mesenchymal Transition (EMT). The Arur laboratory discovered that DICER1 is phosphorylated by active ERK and that ERK-mediated phosphorylation triggers DICER1 to translocate from the …
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
<p>Tumor recurrence following initial treatment is the leading cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression and to facilitate appropriate responses to environmental cues. However, it is increasingly appreciated that epigenetic …
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Hypoxia Mediated Downregulation of Mirna Biogenesis Leads to Increased Tumor Progression
… been a growing recognition of the importance of tumor associated microenvironment in the initiation and progression of tumors. However, a mechanistic understanding of the complicated biological interplay between the stromal framework and malignant regions of the tumor remains incompletely …
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Role of the Activin/Follistatin system during angiogenesis and tumor progression
… to examine the role of AC/FS system in tumor angiogenesis and tumor growth. To address these questions, three different model systems were utilized: (i) 3D in vitro sprouting angiogenesis model, (ii) in vivo Matrigel assay and (iii) xenotransplant tumorigenesis assay. Results confirmed …
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The role of phosphoglycerate dehydrogenase in cell proliferation and tumor progression
… disease of inappropriate cell proliferation, and tumor cells require a unique metabolic program to support proliferation. Phosphoglycerate dehydrogenase (PHGDH) catalyzes the first step in the serine biosynthesis pathway, and the gene encoding this enzyme is amplified in human cancer. …
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The Roles of Malt1 In Nf-Κb Activation and Solid Tumor Progression
… it has been suggested thatNF-κB is critical in tumorigenesis and tumor progression, the molecular mechanism by which NF-κB is activated in solid tumor remains largely unknown. In the current work, we focus on growth factor receptor-induced NF-κB activation and tumor progression, including …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
<p>Hypoxia is a hallmark of most solid tumors. In response to hypoxic stress tumor cells adapt by regulating survival, metabolism and angiogenesis. The heterodimeric HypoxiaInducible Factor (HIF) transcription factors are the master regulators of this response. HIFs play key roles in many critical …
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
… and colon cancer; moreover, it functions as a tumor suppressor capable of inhibiting tumor cell growth both in vitro and in vivo. In this study, we show that a putative tumor suppressor, miR-145, is regulated through the phosphoinositide-3 kinase (PI-3K)/Akt and p53 pathways. Importantly, p53 …
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Functional study of the IFITM1 gene related to tumor progression of NF1
"국문요약 i 차례 iv 그림차례 v 표차례 vi Ⅰ. 서론 1 Ⅱ. 재료 및 방법 9 1. Tissue sample 9 2. Primary fibroblast 배양 10 3. 유전자 과발현을 위한 IFITM1 construct 구축 10 4. Total RNA 추출 및 cDNA 합성 12 5. RT-PCR (Reverse Transcription-PCR) 12 6. Western blot analysis 13 7. Ras activation assay 15 8. Cell death assay 15 9. Transfection …
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Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
… were based on the hypothesis that metastatic progression in bone is a result of a cooperative effort between bone marrow adipocytes, macrophages, osteoclasts, and PCa cells. We specifically focused on two adipocyte-supplied chemokines, CXCL1 and CXCL2, and bone marrow macrophage-secreted …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… polarity determinants may contribute to ductal tumor progression. Podocalyxin is an anti-adhesive glycoprotein that may be involved, as it is important in epithelial morphogenesis, and its overexpression in clinical breast tumors is associated with poor outcome. Despite this, overexpression of …
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Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
… lipid availability has been implicated in tumor initiation, growth,and metastasis, and metabolic genes involved in lipid uptake and synthesis are downstream of oncogenic alterations.Though excess lipids are known to correlate with disease progression, the precise enzymatic players required …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… in the United States. The long latency of PCa tumorigenesis provides ample opportunity for chemopreventive strategies to be applied. Generally, phytochemicals have diverse impacts on multiple pathways that can affect cancer cell growth and metabolism. Using combinations of compounds that target …
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Development of Tools to Assess the Effects of Lunasin on Normal Development and Tumor Progression in Drosophila Melanogaster
… cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. In this study we attempt to understand the developmental effects of Lunasin overexpression in vivo and create reagents that will help us understand Lunasin’s anti tumorigenic effects in an intact …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
… suppressed the growth of LNCaP-abl xenograft tumors by 81%. Tumor growth suppression was associated with decreased tumor cell proliferation, as determined by proliferating cell nuclear antigen (PCNA) levels, and modulation of intratumoral biomarkers associated with cell survival, growth, and …
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Therapeutic Aerobic Exercise in a Mouse Model of Breast Cancer: Effects on Tumor Progression, Angiogenesis, and Response to Chemotherapy
… mechanisms by which physical activity affects tumor physiology are poorly understood. Accordingly, clinicians lack critical information to properly advise breast cancer patients on the use of exercise as an adjunct to more conventional therapies.</p><p>The beneficial effects of exercise on …
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Application of the single cell genomics in deciphering tumor heterogeneity and its role in tumor progression and drug resistance
Tumor progression, from the single mutated cell to the advanced stages of cancer, represents an evolutionary process. During tumor progression, cancer cells acquire new genetic mutations, becoming more heterogeneous, leading to tumor progression and resistance to therapy. However, clear genetic …
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