Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"tumor plasticity"”.
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Understanding tumor cell plasticity in spatial transcriptomics with graph attention networks and walk-based pseudotime analysis
Tumor cell plasticity in cancer is a key driver in tumor progression, heterogeneity, metastasis, and treatment resistance. Tumor cells change states from the conventionally easier to treat epithelial state to the more resistant mesenchymal state. Understanding the transition dynamics of these …
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ASCL2 Positive Tumor Cells Modulate the Response of Metastatic Colorectal Cancer to MAPK-Targeting Therapy
… heterogeneity. Due to its central role in tumorigenesis, CRC is commonly treated with MAPK pathway inhibitors (MAPKi). However, clinical trials repeatedly demonstrates that durability of benefit is short-lived in many patients. While genomic mechanisms of acquired resistance have been …