Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"tumor penetration"”.
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PRECLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION OF NEW ANTICANCER AGENTS FOR BRAIN TUMOR CHEMOTHERAPY
… (GBM) is the most common malignant primary brain tumor in adults for which overall prognosis remains poor despite recent treatment advances, thus emphasizing the need for developing effective therapeutic agents. Styryl sulfones belong to a class of non-ATP competitive antineoplastic agents in …
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Exploring multivalency and chemical modifications in the development of anti-PD-L1 peptide inhibitors for cancer immunotherapy
… to drawbacks associated with Abs, such as low tumor penetration, high immunogenicity, and prolonged occupancy of target receptors. Over the past decade, peptides have garnered considerable interest as promising alternatives to address the limitations of existing anti-PD-L1 therapies and to …
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Bacteria-Enabled Autonomous Drug Delivery Systems: Development, Characterization of Intratumoral Transport and Modeling
… but also on the transport of the drug to all tumor cells in sufficient concentrations. Intratumoral drug transport is limited by characteristics of the tumor microenvironment such as elevated interstitial pressure and sparse, irregular vascularization. Moreover, poor tumor selectivity, leads …
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Rational engineering strategies to improve antibody fragment pharmacokinetics and bioavailability
… affords favorable properties such as increased tumor penetration as well as the ability to utilize lower-cost prokaryotic production methods. However, they suffer from poor pharmacokinetics in vivo. This poor pharmacokinetic profile can be attributed to multiple factors, including an inability …
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Quantitative analysis of perivascular antibody distribution in solid tumors
… shown efficacy in a range of blood and solid tumors. Antibodies targeting solid tumors face considerable transport barriers in vivo, including blood clearance, extravasation, diffusion within the tumor interstitium, binding to antigen, endocytosis, and degradation. The unique pathology of the …
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Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
… tissues and concentration of the drug within the tumor. As such, encapsulation of chemotherapeutic agents inside nanoparticles capable of enhancing tumor-targeted drug delivery is a particularly promising innovation. Yet, initial investigations into the intratumoral fate of nanomedicines have …
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Peptide Targeted Drug Delivery to Non-Small Cell Lung Cancer
… is expressed in more than half of NSCLC patient tumor samples and only rarely expressed in normal tissue. Importantly, αᵥβ₆ is turned on early in the disease progression of NSCLC, indicating that it may be a good biomarker for early cancer detection and treatment. The phage display selected …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… has efficacy in SCID mice with human B cell tumors. Furthermore, homodimers consisting of two conjugated IgG molecules of HD37 are more effective than monomers at inducing tumor cell death. Yet, their large size prevents effective tumor penetration, and normal Fc effector funtions are often …
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Engineering antibodies for improved targeting of solid tumors
… due to their ability to specifically bind tumor-expressed antigens. Unfortunately, attempts to treat solid tumors with these drugs are often limited by an inability of the antibodies to fully penetrate the tumor tissue, leaving large regions of untargeted and viable cells. The goal of this …
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DUPA α-Amanitin Conjugates for Targeted Prostate Cancer Therapy - Optimization and Evaluation of In Vivo Potency
… the main limitations in the use of ADCs in solid tumor therapy seems to be restrained tumor penetration due to the high molecular size of this class of therapeutics. In this work a library of small molecule drug conjugates (SMDCs) as an alternative for large molecular ADCs was developed and tested …
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Engineering Tumor-Targeting Bacteria and Characterizing Their Interactions with Tumor Cells in Therapy-Resistant Breast Cancers
… or resistant ER+, and Luminal B tumors. For these high-risk subtypes, molecular heterogeneity undermines targeted therapies, and clinical management still relies on maximum tolerable doses of systemic chemotherapy, causing severe dose-limiting toxicities. Moreover, the dense …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
… lesions, complete surgical removal of solid tumor may be impossible. Adjuvant chemotherapy is often associated with significant dose-limiting systemic toxicities, and can lead to platinum-resistant disease. To date, there are no FDA-approved therapies that significantly prolong the overall …
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
… growth factor (VEGF) can transiently normalize tumor vasculature, thereby improving delivery of systemic chemotherapy. Bevacizumab (BEV), an anti-VEGF antibody, has been shown to transiently normalize tumor vasculature by increasing tumor vessel maturity, decreasing tumor vessel permeability, …
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Discovery of IKBKE and CD24 siRNAs for the treatment of triple-negative breast cancer
… surface protein and plays an important role in tumor growth, invasion, and metastasis. Moreover, overexpression of CD24 in tumors is associated with resistance to therapies. Small interfering RNA (siRNA) can specifically knockdown the expression of target genes. It represents a promising tool …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… in the treatment of central nervous system (CNS) tumors such as malignant glioma have only been modest. One particular challenge facing treatment of brain tumors is the delivery of therapeutically effective concentrations of anti-cancer agents to the target site in the brain. The sanctuary of the …