Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"tumor necrosis factor (TNF)"”.
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… loss in PD. A number of cytokines, including TNF, are elevated in post-mortem brain and cerebrospinal fluid of patients with PD. Previous studies from our group have shown that blocking solTNF signaling at the time of a unilateral 6-OHDA striatal lesion attenuated behavioral deficits and the …
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Screening of the human tumor necrosis factor (TNF) gene and its receptor 1 (TNFR1) gene for DNA alterations and the subsequent investigation of these and an IL12p40 polymorphism for an association with paediatric tuberculosis
… diverse outcome are poorly understood, but host factors are thought to play an important role. In particular, a genetic component to susceptibility to tuberculosis has been proposed. An important clue was the description of a group of Maltese children with an unusual susceptibility to progressive …
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The effect of potential anticancer gene products on breast cancer cell lines
… to evaluate three different potential anticancer factors, decorin, interferon beta (IFNb), and tumor necrosis factor (TNF) related apoptotic inducing ligand (TRAIL). The overall hypothesis was that combinatorial treatment of two of anti-cancer factors would be more efficacious and exhibit less …
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Mechanisms of TRAF Signaling
… mechanisms of signal transduction activated by tumor necrosis factor (TNF) superfamily proteins. Ligands of the TNF family engage TNF receptor (TNFR) family proteins, leading to a wide variety of cellular effects, these interactions are implicated in inflammation, immune regulation, bone …
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Quantitative analysis of adenoviral vector modification of a cytokine-mediated cell death decision
… an adenoviral vector (Adv) sensitizes human tumor epithelial cells to tumor necrosis factor (TNF)-induced apoptosis. We first measured TNF-stimulated signaling profiles over a range of Adv infection levels for a distribution of kinases centrally involved in the TNF signaling network. We then …
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DUSP5 Regulation of Inflammation and Insulin Signaling
… is characterized by increased expression of tumor necrosis factor ? (TNF?). TNF? stimulates signaling of mitogen-activated protein kinases (MAPKs) within adipocytes (i.e. fat cells) and muscle cells that drive systemic inflammation and insulin resistance, leading to T2D. Until recently, most …
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The Tumor-Suppressive Properties of Neural Stem Cells
… of neural stem cells (NSCs) towards the tumor. This migration reflects the NSC wound repair response following CNS injury. Studies using NSCs surgically implanted into GBM tumors showed decreased tumor growth and increased animal survival in mice; however, the mechanisms underlying these …
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The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy
… analysis of gene microarrays. We found that Tumor Necrosis Factor (TNF) mediates axonal-Schwann cell communication, and that disruption of TNF signaling results in sensory and tissue dysfunction. These findings indicate that the threshold of wild-type physiological function in peripheral …
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Ligand-Directed Aavp to Deliver A Therapeutic Transgene to Neuroendocrine Tumors of The Pancreas
<p>Human pancreatic neuroendocrine tumors are rare tumors that form in the endocrine pancreas. Patients with these tumors have limited therapeutic options, and curative intervention is limited to surgical resection. These tumors do, however, consistently express somatostatin receptor type 2 (SSTR2) …
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Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha
… that has been identified as a blood-borne factor inherently linking feeding behavior and metabolism to the individual's nutritional state. The studies detailed herein examine hyperleptinemia elicited by tumor necrosis factor (TNF) alpha at many levels. Initial studies determined that …
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The Role of the CD14 molecule in equine endotoxemia
… antibodies (mAbs) to equine CD14 on LPS-induced TNF° expression of equine peripheral blood mononuclear cells (PBMCs). To determine serum concentrations of soluble (sCD14) in a population of horses with gastrointestinal diseases or other illnesses likely to result in endotoxemia; and identify …
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Investigating the Role of Pellin03 in TNF Signalling
Tumor necrosis factor (TNF) is an important modulator of the innate immune system, responsible for the activation of immune cells as well as the removal of damaged cells. Aberrant TNF signalling can cause a number of pathologic conditions. TNF binding to TNF receptor 1 triggers the activation of …
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The role of fibrolast-derived cytokines on melasma
… radiation, sex hormone, and genetic predisposing factors, however, the exact mechanism of pathogenesis is not clearly demonstrated. Previous studies have been bringing focus into the pigmentation formed by interaction between keratinocytes and melanocytes. Recently, it was reported that dermal …
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Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum
The object of this study was to compare growth factor and cytokine profiles in canine autologous conditioned serum (ACS) to canine plasma. Blood collected from 16 medium to large breed dogs was used to produce ACS (Orthokine® vet irap 10 syringes) and citrated plasma (control). Canine-specific …
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Cell-surface Tumoricidal Molecules and NF-kB in the Tumor-burdened Host
Tumor-distal immune suppression promotes tumor growth by preventing the recruitment of leukocytes to the tumor-proximal microenvironment. Tumor necrosis factor (TNF)-a is both secreted by and expressed on the cell-surface (mTNF-a) of macrophages. When stimulated with LPS, tumor-burdened host (TBH) …
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Cytokines and aeroallergens in the pathogenesis of summer-pasture associated obstructive pulmonary disease: effects on endothelin production, neutrophil activation and chemotaxis
… for differentiation. Cytokines IL-4 and tumor necrosis factor (TNF)-α induced up-regulation and directional (basolateral) release of ET-1 by differentiated airway epithelial cells, grown under air-liquid interface.
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Purification of SIMPL Antibody and Immunofluorescence of SIMPL Sub-Cellular Localization in Response to TNFα- and IL-1
… that alters the activity of transcription factor, NF-κB. In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal through the IL-1 and TNF-α receptors, respectively, which are found on various cell types. Activation of these receptors can …
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Production and Characterization of an Human Monoclonal Antibody IgG to TRAIL Receptor 2
Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) 은 TNF superfamily에 속하며, 수용성 TRAIL의 경우 DR4와 DR5및 결합하여 다양한 암세포에 세포독성을 가질 뿐 만 아니라, 정상세포에서는 세포독성이 적어 암 치료제로서 가능성이 높게 평가되고 있다. 그러나 수용성 TRAIL의 경우 불안정하며, 사람의 hepatocytes에서 세포독성을 일으킬 수 있고, TRAIL에 의한 저항성을 가지는 암세포 또한 보고된 바 있다. 따라서 현재는 …
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… signaling in mononuclear phagocytes induces tumor necrosis factor (TNF)-α hyperproduction and lethal inflammatory lung damage, with no detectable benefit to viral or bacterial clearance. In contrast, we show that interleukin (IL)-10 is crucial to counteract the lethal IFN-γ-induced cytokine …
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Medication utilization for rheumatoid arthritis among commercially insured patients
Background: Tumor necrosis factor inhibitor (TNFi) and non tumor necrosis factor (TNF) biologics are specialty drugs recommended by the American College of Rheumatology (ACR) guideline for the treatment of rheumatoid arthritis (RA). Barriers to their use include cost, side effects, and route of …
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