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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 280 for “"tumor necrosis factor"”.
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Determining the Roles of Q-SNAREs in Mast Cell Tumor Necrosis Factor Exocytosis
<p>As evidence accumulates on the contributions of mast cell function to the development of allergic disorders, cardiovascular and neurological pathologies, and cancers, there is a growing recognition of the importance of mast cell-derived TNF to mast cell-mediated pathophysiology. However, our …
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The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy
… analysis of gene microarrays. We found that Tumor Necrosis Factor (TNF) mediates axonal-Schwann cell communication, and that disruption of TNF signaling results in sensory and tissue dysfunction. These findings indicate that the threshold of wild-type physiological function in peripheral …
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Identifying Depression Utilizing Tumor Necrosis Factor–[alpha] and Endothelial Function in Spinal Cord Injury
… symptomology, biomarker derangement of tumor necrosis factor-alpha (TNF-α), and endothelial function in people with SCI. SCI participants showed higher levels of depression, TNF-α and shorter time to reach maximum level of nitric oxide (NO)-dependent vasodilation. Although these …
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The multiple organ dysfunction syndrome in mice. Characterization and interventions at tumor necrosis factor.
Contains fulltext : 146548.pdf (Publisher’s version ) (Open Access)
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The Role of Tumor Necrosis Factor-Stimulated Gene 6 Protein (TSG-6) in Osteoarthritis
… OA progression in human articular cartilage. Tumor Necrosis Factor-Stimulated Gene 6 (TSG-6) was identified to be significantly associated with OA progression and validated in both medial and lateral compartment dominant OA samples. </p><p>Next, we explored mechanisms underlying the …
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Tumor Necrosis Factor Dependent Mechanisms and Neuroprotective Strategies in Models of Parkinson's Disease
… are unclear. Elevated levels of the cytokine tumor necrosis factor in cerebrospinal fluid and postmortem brains of Parkinson's patients and in animal models of the disease implicate tumor necrosis factor in contributing to disease pathology; but a specific role for this cytokine in mediating …
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Tumor necrosis factor-alpha- and interleukin-1-induced cellular responses: coupling proteomic and genomic information
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-α
Tumor necrosis factor-a (TNFa) is primarily a macrophagederived cytokine. TNFa, in vitro, kills or inhibits growth of approximately one third of surveyed transformed cell lines dincluding the L929 and WEHI 164 murine fibrosarcoma cell lines. Very little is known about the mechanisms of TNFa action. …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… is the primary microglia-derived inflammatory factor that compromises survival of dopaminergic neurons. Furthermore, these studies suggest that TNF-dependent neuroinflammation directly contributes to the delayed and progressive degeneration of nigral DA neurons after neurotoxic injury and …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… accompanied by a decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of nitric oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be …
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Tumor necrosis factor induced oxidative stress in the central nervous system contributes to sympathoexcitation in heart failure
… in the pathogenesis of CHF. The increase in tumor necrosis factor (TNF), a primary PIC, correlates closely with heart disease severity. Moreover, central PIC production increases post-MI, and can affect the brain’s cardiovascular regulatory regions that control sympathoexcitation. Therefore, …
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Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms
… unknown, but are probably related to host immune factors. Cytokines play significant roles in inflammatory and immune defense. This study was undertaken to investigate the association between HBV infection and polymorphisms of tumor necrosis factor-a (TNF-α) and interleukin-10 (IL-10) gene …
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Modulation of macrophage tumor necrosis factor-alpha production by omega-3 polyunsaturated fatty acids, eicosanoids, and calcium
Made available in DSpace on 2011-05-07T13:06:27Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9411584.pdf: 5136937 bytes, checksum: e2d5ecc84f036f49d27c51932622b5b8 (MD5) Previous issue date: 1993
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Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha
… that has been identified as a blood-borne factor inherently linking feeding behavior and metabolism to the individual's nutritional state. The studies detailed herein examine hyperleptinemia elicited by tumor necrosis factor (TNF) alpha at many levels. Initial studies determined that …
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Regulation of tumor necrosis factor-alpha induced apoptosis via posttranslational modifications in a human colon adenocarcinoma cell line
… time points during early apoptosis induced by tumor necrosis factor-α
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Regulation of Tumor Necrosis Factor-alpha Signaling in Rheumatoid Arthritis Synovial Fibroblasts by Green Tea Polyphenol Epigallocatechin-3-gallate
… when cytokines, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α, stimulate synovial fibroblast proliferation leading to joint damage and destruction. Epigallocatechin-3-gallate (EGCG) is a polyphenol found in green tea that has been shown to have an anti-inflammatory effect in RA. …
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Tumor Necrosis Factor-α Production By Murine Peritoneal Macrophages in Response to Candida Albicans Yeasts, Germ Tubes, and Mycelia
… the production of a variety of cytokines, one is Tumor Necrosis Factor-α. TNF-α has been implicated as a mediator in endotoxic shock syndrome. However, there is also evidence that this cytokine can have beneficial effects when produced at low levels. The focus of this study was to determine if …
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