Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"tumor models"”.
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AGO2 in overexpression exhibits oncogenic functions KrasG̳1̳2̳D̳ -associated mouse tumor models
… and growth. Simultaneously, mutations in tumor suppressor genes are frequently detected, allowing cells to evade cell cycle checkpoints, resulting in the inhibition of cell death signals. Therefore, identifying genetic abnormalities that promote tumor initiation and progression is …
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Identification and Knockout of Immunodominant Endogenous Retroviral Antigen in Murine Tumor Models
… the dominant role of T cells in an anti-tumor response, but the functional role of B cells and their antibodies in cancer remains less clear. In murine tumor models, curative immunotherapies have been previously shown to result in the development of immunotherapy-induced antibodies …
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Noninvasive Assessment of Tumor Hypoxia Using MRI in Clinical and Preclinical Tumor Models
Tumor oxygenation influences response to radiation and plays important roles in malignant progression, angiogenesis and metastasis. While methods are available to quantitatively map pO2 dynamics in preclinical studies, new techniques are needed to noninvasively characterize tumor hypoxia and …
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Experimental evaluation and mathematical modeling of the pharmacokinetics of boronophenylalanine-fructose (BPA-f) in murine tumor models
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1999.
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Engineered microsystems and their application in the culture and characterization of three-dimensional (3D) breast tumor models
… have been utilized for engineering the tumor extracellular matrix, but very few studies have thoroughly characterized the phenotypic changes in their cell models, which is critical for translational applications of biomaterial systems. The overall objective of these studies is to …
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Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and 18F Misonidazole PET in Murine Tumor Models
http://pubs.rsna.org/doi/full/10.1148/radiol.2015150416
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Locally Administered Particle-Anchored Cytokines Safely Enhance Cancer Immunotherapy
… been proposed as a powerful approach to curing tumors, based on the natural function of the immune system in protecting its host with specificity, thus holding the potential for developing long-term memory that prevents tumor recurrence. However, the immunosuppressive feature of the tumor …
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Engineered Platforms for the Development of Electroporation-based Tumor Therapies
… the clinic, however, are limited in the size of tumors that they can safely treat without increasing the applied voltage to an extent that induces thermal damage or muscle contractions in patients. A method to increase ablation size safely is needed. To make this advancement and to advance other …
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Investigations into therapeutic discovery and delivery of heparin-like glycosaminoglycans
… in cancer growth, metastasis and angiogenesis, tumor systems were studied using heparinases I and III which have distinct substrate specificities. Studies, focusing on the biochemistry of the heparinase active site, elucidated key interactions important for enzymatic activities, thus enabling …
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Experimental brain tumors, dendritic cells and immunotherapy
… astrocytomas are the most common primary tumors of the adult central nervous system. Surgical resection of tumor mass in combination with radiotherapy and chemotherapy is only palliative and there is a clear need for new and more effective therapeutic strategies. The aim of this study was …
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Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… Lymphoma. However, treatment of solid tumors by radioimmunotherapy remains a challenge, driven in part by a lack of high affinity antibodies against highly tumor-selective surface antigens. Herein, we characterize novel<sup> </sup>anti-B7-H3 immuno-conjugates for PET imaging and RIT of …
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Engineering Tumor-Localized Therapies for Cancer – from Antioxidant Enzymes to Cytokines and Radiation Therapy
… the treatment of cancer, improving tumor control and increasing survival in a growing subset of cancer patients. Immunotherapies activate the patient’s immune system to recognize and kill cancer cells, while targeted therapies broadly target molecules or pathways involved in growth …
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Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide and Tumor Escape
… to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted the transfer of the CAR-cognate-antigen from tumor to NK cells, resulting in (1) lower tumor antigen density, thus …
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뇌종양 동물모델에서의 인간신경줄기세포주의 종양으로의 특이적 이주에 관한 입체적 분석
… culture 3 2. In vivo protocol of experimental tumor models 3 3. In vitro and in vivo cell proliferation assays 4 4. In vivo analysis of tumor-tropism of human neural stem cells 5 5. X-gal stain 6 6. Cell count and unbiased stereology in a tumor region of rats 7 7 .Cell count and unbiased …
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Development of PAC-1 as a privileged agent for combination chemotherapy
… cancer cells and be efficacious in select murine tumor models. Described herein is the evaluation of PAC-1 in combination with diverse chemotherapeutics, and leveraged for the treatment of challenging cancers. Concurrent external development of a second class of mechanistically-distinct …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… anti-PD-1 therapy. Depletion of PTDSS1 in tumor cells increased expression of IFNγ-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1. Loss of PTDSS1 in tumor cells also led to increased expression of MHC-I, which was associated with increased expression of cytolytic function related …
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Tissue oxymetry using magnetic resonance spectroscopy
… The implementation of this method in stroke and tumor models is discussed. Thesis Supervisor: Bruce Jenkins
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Type 1 Interferon: A Negative Regulator Of Myeloid-Derived Suppressor Cells Function In Cancer
… activity. These cells play an important role in tumor progression and limit the efficacy of cancer therapies. Whereas many pathways stimulate the generation of MDSC, the key natural mechanisms restricting these processes are not well understood. Here, we present evidence that type I interferons …
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