Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"tumor model"”.
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Radioimmunotherapy in an Immunocompetent Tumor Model utilizing a 177Lu-mAb
… conjugated to monoclonal antibodies that bind to tumor-associated antigens in the tumor, so that the decay of the radionuclide takes place inside the tumor. The aim of the research presented in this thesis was to investigate the effects of RIT (utilizing the radioconjugated antibody 177Lu-BR96) on …
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Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
… complexity of the native three-dimensional (3D) tumor microenvironment, resulting in a lack of correspondence between preclinical data and clinical trial outcomes. The establishment of high-throughput 3D models able to describe distinctive aspects of the tumor niche would advance our …
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A three-dimensional in vitro tumor model representative of the in vivo tumor microenvironment
… reproduce the complexities of the in vivo tumor microenvironment with reductionist-based two-dimensional in vitro cell culture models has been a notable deterrent in identifying therapeutic agents that reliably translate to in vivo animal and human clinical trials. In an effort to address …
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
Glioblastoma multiforme (GBM) are deadly brain tumors that are refractory to radiation and chemotherapy. Despite decades of work, little progress has been made in improving patient outcomes. Recent mapping of the GBM genome by the Cancer Genome Atlas Network revealed that these cancers commonly …
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A TISSUE ENGINEERING APPROACH TO THE DEVELOPMENT OF AN IN VITRO 3D TUMOR MODEL FOR DRUG DELIVERY STUDIES
The lack of good preclinical models has hampered anticancer drug discovery. Standard preclinical protocols require the growth of cells in high throughput two-dimensional culture systems. Such in vitro drug testing methods yield drug efficacy results that differ greatly from animal models. It is …
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VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM
Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a …
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A foe-inspired friend: Constructing a tumor tissue-mimicking biomaterial to study intratumoral drug transport
The design of an in vitro model of the tumor microenvironment and its implementation on drug screening of new anticancer therapies is an active challenge that sits at the interface of biomaterials and cancer biology. As recent clinical successes of human intratumoral therapies stimulate research on …
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The Combined Effect of In-Situ Tumor and Irradiation on Peritumoral Brain Vasculature
<p>In the USA, 200,000 brain tumors are diagnosed each year with glioma representing 8.4% of the 200,000. The standard treatment for glioma consists of surgical resection, when possible, followed by radiation therapy (RT) and/or chemotherapy. Radiation therapy is one of the most effective …
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Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
… clinical trials of novel drugs targeting the tumor vasculature using gadolinium-DTPA (Gd) as a contrast agent. However, it has some limitations, such as reproducibility, data acquisition times, the presence of noise, extracting contrast concentration, estimating T1 relaxation and estimating …
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Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
… oncoproteins E6 and E7, which serve as ideal tumor specific antigen targets. An effective therapeutic vaccine should be able to overcome tumor mechanisms of immune-evasion and immune-suppression, while inducing a robust anti-tumor mediated response. In this dissertation I investigated a novel …
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Apple vision pro for intraoperative 3D tumor visualization and surgical guidance
… headset for visualizing and localizing brain tumors during neurosurgical procedures. A complete workflow was developed to overlay a CT-derived 3D tumor model onto a patient-specific head surface mesh obtained using LiDAR scanning and machine-learning–based object tracking. A 3D-printed head …
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Examining autoimmune sequelae during cancer immunotherapy in a combined autoimmune thyroiditis and tumor mouse model
… autoimmune thyroiditis (EAT), a mouse model of Hashimoto's thyroiditis (HT), the importance of regulatory T cells (Tregs) has been well established; inhibition of Tregs leads to enhanced thyroiditis with repeated doses of mouse thyroglobulin (mTg) without adjuvant. To simulate cancer …
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
… CD8⁺ T cell responses, leading to significant tumor regression and prevention in a mouse tumor model. These results support αCD40-mSAs as an 'all-in-one' vaccine delivery platform with multifunctional immunopharmacological advantages and strong translational potential for personalized cancer …
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Adrenergic Mobilization of the Immune System and the Anti-Cancer Effects of Exercise
… potential, and evidence exists for an anti-tumor effect of exercise dependent upon NK-cells or CD8+ T-cells relative to the specific tumor model. We herein demonstrate that blockade of the β2-AR in humans during exercise significantly blunts the mobilization of lymphocytes, while β1-AR …
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
<p>Tumor growth often outpaces its vascularization, leading to development of a hypoxic tumor microenvironment. In response, an intracellular hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of …
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Nanomaterials for the detection of cancer-associated biomarkers
… thesis focuses on optical detection of prostate tumors through the development of biomarker-targeted molecular imaging probes. In the first part of this work, engineered human prostate cancer cell lines were developed and characterized to determine the dynamics of post-translational processing …
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Function follows form: novel structured encapsulation materials via microfluidics
… on the development of a high-throughput tissue model system and investigates the effects of cellular encapsulation and geometric effects of vasculature on tumorous tissue behavior. Similar in the way that cells are directly influenced by the stiffness of their substrate, we found that tumors are …
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