Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 404 for “"tumor microenvironment"”.
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence indicates that, besides current known immune …
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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
… in children comprising 4% of all pediatric tumors. Early intervention increases survival rates up to 95% in developed countries; being survival rates associated to socio-economic status. Despite the high survival rates in developed countries, preservation of the eye and vision are continuing …
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Exploring the tumor microenvironment of immunogenic cancers
Contains fulltext : 302594.pdf (Publisher’s version ) (Open Access)
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CHCHD2 and the tumor microenvironment in glioblastoma
… aggressive, and deadly form of primary brain tumor in adults, with a median survival time of only 14.6 months. GBM tumors present with chemo- and radio-resistance and rapid, diffuse invasion, making complete surgical resection impossible and resulting in nearly universal recurrence. While …
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… cells face substantial pressure within the tumor microenvironment. Physical constraints and nutrient limitations in the tumor prevent excessive cell proliferation, while other cell types such as stromal and immune cells can compete with or kill cancer cells. To overcome these restrictions, …
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Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma
… In cancer, cell-to-cell interactions between tumor cells and their microenvironment are critical determinants of tumor tissue biology and therapeutic responses. Interactions between glioblastoma (GBM) cells and endothelial cells (ECs) establish a purported stem cell niche. We hypothesized that …
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Interrogations of The Tumor Microenvironment Using Magnetic Resonance Imaging
<p> Both tumor acidosis and tumor hypoxia are characteristics commonly found in the microenvironment of solid malignant tumors. Accurate characterization of the two phenomena could provide important information to clinicians for devising suitable treatment plans. Tumor acidosis and hypoxia are …
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Role of biomechanics and tumor microenvironment in osteosarcoma progression
… presents research conducted under the themes of tumor heterogeneity, mechanobiology and the tissue microenvironment. It aims to understand the different influences, physical and biochemical, present in the osteosarcoma tissue microenvironment and connect them to give a broader understanding of …
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The Role of Fusobacterium nucleatum in the Tumor Microenvironment
… characterization of microbes in several tumors including colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) has revealed the presence of multiple species of intracellular bacteria within tumors. However, there is limited knowledge on how these bacteria colonize tumors, …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… in a less differentiated mesenchymal-like tumor cell phenotype, which reinforces the need for effective companion therapies. Cyclooxygenase-2 (COX-2) inhibition has been shown to promote tumor cell differentiation and improve standard therapy response in pancreatic cancer. Here, I evaluate …
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Elucidating The Roles of Il-15 In The Tumor Microenvironment
<p>ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT</p> <p>Rosa M. Santana Carrero, B.S.</p> <p>Advisory Professors: Shao-Cong Sun, Ph.D. & Kimberly S. Schluns, Ph.D.</p> <p>Interleukin-15 (IL-15) is a factor that promotes activation, proliferation, cytotoxicity, and survival of CD8 T …
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Generative modeling of the tumor microenvironment : deconvolution, completion, and integration
Modern biological measurement technologies provide increasingly diverse views of tissue state, including spatial transcriptomics, spatial proteomics, and multi-sequence medical imaging. However, the data collected by these platforms is often incomplete, aggregated, or distributed across unpaired …
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Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
<p>In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. Additionally, cancer cells exposed to these stresses are more resistant to therapies, more likely to metastasize and often are …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
The causes underlying the extent and character of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of individual patients. Tumors are complex and organized tissues that include …
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Computational analysis of cell-cell communication in the tumor microenvironment
… stromal cells influences many aspects of in vivo tumor biology, including tumorigenesis, tumor progression, and therapeutic resistance. As a result, targeting receptor-ligand interactions, for instance with immune check-point inhibitors, can provide significant benefit for patients. However, our …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… part due to the presence of an immunosuppressive tumor microenvironment (TME), driven by a highly desmoplastic stroma in mBC. For my dissertation, I explored strategies to re-engineer the desmoplastic TME to overcome therapeutic resistance to immune checkpoint blockade (ICB), and developed an …
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Development of Quantitative Ultrasound-Mediated Molecular Imaging of The Tumor Microenvironment
… and characterization of biomarkers within the tumor microenvironment (TME), which can then be combined with the anatomical information provided from diagnostic imaging.</p> <p>Two such biomarkers of interest are blood oxygen saturation (SO<sub>2</sub>) and cell receptor expression. SO<sub>2 …
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Bhlhe40: Required For Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
… of various cancers, such as those with high tumor burden like melanoma(Brahmer et al., 2012; Hodi et al., 2010). Immunotherapy, specifically immune checkpoint therapy (ICT) provides antagonist effect on specific immune checkpoints to control effector T cell functions(Pardoll, 2012). This …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… the most aggressive breast cancer subtypes. The tumor microenvironment (TME) is critical in driving these aggressive breast cancers' clinical phenotype and aggressiveness. Therefore, we explored novel actionable targets and complementary therapies targeting the TME to improve the outcomes of …
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