Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"tumor metastasis"”.
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Functional Analysis of the Tumor Metastasis Suppressor, NDRG1
Metastasis suppressors regulate multiple steps during the process of dissemination of tumor cells from primary sites to distant organs, while they do not affect the growth of the primary tumor. Previously, we identified NDRG1 (N-myc downstream regulated gene 1) as a tumor metastasis suppressor gene …
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A role for the Spemann organizer gene, Goosecoid, in tumor metastasis
The process of invasion and metastasis during tumor progression is often reminiscent of cell migration events occurring during embryonic development. I hypothesized that genes controlling cellular changes in the Spemann organizer at gastrulation might be reactivated in tumors. The Goosecoid …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
Solid tumors typically require angiogenesis, the development of new blood vessels, for growth and metastasis. Vascular endothelial growth factor (VEGF) induces angiogenesis by activating receptors on host endothelial cells. One such receptor, Flt-1, occurs as either a membrane bound or a secreted …
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Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells
… carcinoma progression and metastatic spread of tumors. However, the precise mechanism and molecular basis of metastasis promotion by E-cadherin loss is not completely understood. To investigate its role in metastasis, I utilized two distinct methods of E-cadherin inhibition that distinguish …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… of endothelial glycocalyx is an early event in tumor cell (TC) adhesion and transmigration across vascular barriers. But how glycocalyx of TC affects TC adhesion and transmigration is unclear. Whether or not glycocalyx can be a target for tumor metastasis is also understudied. Therefore, the 2D …
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Roles of the MicroRNA miR-31 in tumor metastasis and an experimental system for the unbiased discovery of genes relevant for breast cancer metastasis
… as a potent inhibitor of breast cancer metastasis. miR-31 expression levels were inversely associated with the propensity to develop metastatic disease in human breast cancer patients. Additionally, various functional analysis revealed that miR-31 expression was both necessary and …
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Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
Nearly 90% of cancer mortality from solid tumors is due to metastasis of malignant cells to the distant vital organs. It is now well established that a plethora of stromal cells are present within the tumor, and contribute in various ways to tumor initiation and progression, and plasma membrane …
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The Role of the YXXΦ Motif in CD82 Trafficking and Function
<p>CD82, a tetraspanin, is a tumor metastasis suppressor. Tetraspanins are membrane spanning proteins that play critical roles in diverse biological and pathological processes, e.g., the regulation of cancer metastasis. CD82 is ubiquitously expressed in various types of tissues, but its expression …
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Collective cellular behavior on curved surface
… embryonic development, tissue repair as wells as tumor metastasis. While most of existing research of collective cellular behavior are on flat two dimensional (2D) space, most native biological systems however are intrinsically curved, including mature respiratory bronchioles, alveoli, and …
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Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… of DUBs contributes substantially to tumor formation and progression, and therefore targeting DUBs may be a promising cancer therapy strategy. My dissertation focuses on identifying the DUBs of EZH2 and SNAI1, two proteins critical for cancer progression and metastasis, and …
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Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal metastasis. TG2 is a multifunctional protein which catalyzes Ca2+-dependent cross-linking of …
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Ikkalpha Mediated Notch1 Activation Promotes Tumorigenesis Via Foxa2 Suppression
… malignant cell proliferation, angiogenesis, and tumor metastasis in many cancers. However, the mechanism of TNFa-mediated tumor development remains unclear. Here, we show that IKKa, an important downstream kinase of TNFa, interacts with and phosphorylates FOXA2 at S107/S111, thereby suppressing …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… to distant organs, such as bone, lung and liver. Tumor metastasis is responsible for nearly all of the morbidity and mortality associated with BC. Treatments of BC fail in the advanced stage, when metastases have already occurred. To mimic late stage BC in female patients, a mouse model was …
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Synthesis of Novel Antimycobacterials and a Fluorescent Sensor for Simple Carbohydrates
… of biological processes such as inflammation, tumor metastasis, and viral and bacterial infection. The goal of our research has been two-fold. The first objective was the synthesis of antimycobacterial compounds. A mannose containing tetrasaccharide from the mannan core of lipoarabinomannan …
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The role of tunneling nanotubes in mediating intercellular communication in cancer
Tumors are highly heterogeneous entities composed of malignant and stromal cells functioning together as an invasive unit. Effective and efficient intercellular crosstalk in the three-dimensional complex tumor microenvironment is essential for cancer progression. A relatively new mechanism of …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
Tumor initiation and progression depend on the metabolic reprogramming of cancer cells to meet heightened energy and biosynthetic demands. Triple-Negative Breast Cancer (TNBC), characterized by the absence of hormone and HER2 receptors, exhibits high glycolytic and oxidative phosphorylation …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
The process of tumor metastasis is often enabled by the epithelial-mesenchymal transition (EMT), a key developmental program that is often activated during cancer invasion and metastasis. During the EMT process, cells undergo phenotypic changes, lose of E-cadherin expression and acquire invasive …
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Influence of Anti-CD44 on Murine B Cell Activation
… activation, lymphocyte homing/trafficking, and tumor metastasis. Although the functions of CD44 have been shown in T cells and other leukocytes, little is known about its role in B cells. The effects of CD44 cross-linking on murine B cell activation via CD40L/IL-4 was explored using the …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
… lipid, albumin, amyloid beta, etc.), and tumor metastasis. Dysfunction of the lymphatic system thus can lead to various diseases, including lymphedema, lipedema, inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancer, and glaucoma. Despite the significant roles of …
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Investigation of the role of IQGAP1 in metastasis
Metastasis, or the spread of a primary tumor to distal sites in the body, is the major cause of human cancer-related morbidity and mortality. Metastasis requires a complex series of cellular events that remain poorly understood at the molecular level. Recently, advances in microarray technology …
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