Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"tumor metabolism"”.
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The influence of nutrient availability on tumor metabolism
Tumor growth and progression are profoundly influenced by nutrient availability in the tumor microenvironment (TME). Nutrient accessibility not only shapes cancer metabolism but also affects therapeutic responses, genetic dependencies, and metastatic behavior. This dissertation explores how …
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Targeting Tumor Metabolism, Optimizing the tumor microenvironment for radio- and immunotherapy combinations
Contains fulltext : 310749.pdf (Publisher’s version ) (Open Access)
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Investigation of Trophon® 2 For High Level Disinfection of Rigid Endorectal Mri Coils
… superb soft-tissue contrast. However, changes tumor metabolism may precede changes in gross size of the tumor. Newer studies present the use of 13C in MR imaging to interrogate tumor metabolism. With this additional information, not only can the size and makeup of a tumor be obtained, but also …
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Computational modeling of tumor cell growth as a function of nutrient dynamics guided by time-resolved microscopy
… and extreme nutrient conditions found in the tumor microenvironment force reprogramming of metabolism in tumor cells. This metabolic reprogramming has been identified as a hallmark of cancer. This dissertation focuses on the development and validation of an experimental-mathematical approach …
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An Automated Syringe Pump System For Improving The Reproducibility of Dynamic Hyperpolarized Mri Phantoms
… hyperpolarized pyruvate as a contrast agent for tumor metabolism during MR scans has the potential to provide information about tumor metabolism in vivo that is not available from traditional imaging measurements or any other method. Hyperpolarization is achieved through dynamic nuclear …
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Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin
… of aspartate formed via reductive glutamine metabolism promotes resistance to mitochondrial inhibition. Altered metabolism is an important feature of cancer and there is significant interest in understanding how differences in tumor metabolism can be exploited for therapy. NSCLC cells subject …
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Statistical analysis of 11CO2 contamination correction in 11C-acetate PET imaging studies
… on the biological process of interest, such as tumor metabolism, cell proliferation, or blood flow. The most common tracer is fluorodeoxyglucose ([18F]FDG), which accumulates in tissues with high glucose metabolism (e.g., brain, heart, and many tumors), and is used for cancer detection, staging, …
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Examining metabolic vulnerabilities for cancer therapy
… precursors. Many chemotherapeutics that target metabolism are essential components of standard cancer treatment regimens, arguing that there is a therapeutic window to target the metabolic dependencies of cancer cells. However, the use of these drugs as cancer therapies was determined …
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Examining cancer metabolism in vivo
… we address key challenges to study cancer metabolism in the living organism. We present novel experimental and analytical methods to study tumor metabolism in mouse models. This includes: (1) an approach to determine the metabolic fate of any radioactive or stable-isotope tracer in tumors …
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Development of integrated imaging techniques for investigating biomarkers in glioblastoma
… in GBM during the treatment, we observed an antitumor response in GBM after one month. Notably, the index of the ratio of primary metabolites, NAA/Cho, in tumor strongly predicted 6-month overall survival; these data therefore suggest that NAA/Cho is the MRS-detectable biomarker that relates to …
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Improved statistical quantitation of dynamic PET scans
… the specific biologic process (e.g., tumor metabolism, proliferation or blood flow). The standardized uptake value (SUV) obtained at a single time point is widely employed in clinical practice. However, well beyond this simple static uptake measure, more detailed metabolic information …
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Functional Heterogeneity and Metabolic Adaptation of Fibroblasts In Cancer
<p>The tumor microenvironment is comprised of a multitude of cell types producing a milieu of cytokines, growth factors an extracellular matrix. Together, this intricate network of cells plays highly critical roles in determining a tumor’s potential to progress and metastasize. As the predominant …
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Metaboloptics: In Vivo Optical Imaging to Enable Simultaneous Measurement of Glucose Uptake, Mitochondrial Membrane Potential, and Vascular Features in Cancer
<p>Altered metabolism is a hallmark of almost all cancers. A tumor’s metabolic phenotype can drastically change its ability to proliferate and to survive stressors such as hypoxia or therapy. Metabolism can be used as a diagnostic marker, by differentiating neoplastic and normal tissue, and as a …
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The physics of cell-fate choice
… model of the key metabolic pathways active in tumors and other fast-proliferating cells. Our model recapitulates tumor cell behavior across contexts and makes useful predictions concerning the ways tumor cells can evade metabolic therapies. Overall, this thesis describes multiple examples of …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… of detectable MBMs but did not affect primary tumor growth or the incidence of lung metastases. To clarify if OXPHOS promotes the formation of MBMs or the outgrowth of micrometastases, we used an imageable experimental MBM model to demonstrate that IACS-010759 treatment prevented the growth of …
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
… deprivation therapy (ADT). Despite initial tumor regression, PCa inevitably recurs within 2-3 years and becomes known as castration-resistant PCa (CRPC), a terminal and treatment-resistant disease. Second only to potatoes, tomatoes are widely consumed in a variety of forms throughout the …
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… This includes early in development, while the tumor is still manageable, or following initial therapy, when alternative treatments should be considered. The main goal of this project was to determine whether metabolic imaging with hyperpolarized magnetic resonance spectroscopy (MRS) could …