Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"tumor invasion"”.
-
Lattice-gas cellular automata for the analysis of cancer invasion
… autonomous growth, induction of angiogenesis, invasion and metastasis. In this thesis, the focus is on one of the latest stages of tumor progression, tumor invasion. Tumor invasion emerges from the combined effect of tumor cell-cell and cell-microenvironment interactions, which can be studied …
-
PTEN loss induces epithelial-mesenchymal transition in human colon cancer cells
… transition is a critical early event in the invasion and metastasis of many cancers, including colorectal cancer. Chronic inflammation is an inducer of several cancers and inflammatory cytokines have been implicated in tumor invasion. Materials and Methods: Human colon cancer cell lines …
-
Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
… The majority of patients die from local invasion or lymphatic metastasis. The mechanism(s) underlining the invasiveness of HNSCC are poorly understood. Utilizing a panel of HNSCC cell lines previously established in our laboratory, we tested the application and relevance of the three-step …
-
Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
<p>Antiangiogenesis is a promising anti-tumor strategy through inhibition tumor vascularformation to suppress tumor growth. Targeting specific VEGF/R has been showntherapeutic benefits in many cancer types and become a first approvedantiangiogenic modalities by Food and Drug Administration (FDA) in …
-
Viral jun oncogene serves as a suppressor of phorbol ester TPA induced tumor cell invasion and stromelysin gene expression
… whether expression of the v-jun gene in benign tumor forming mouse keratinocytes that already express an activated c-rasᴴᵃ oncogene would cause malignant progression. Our results showed that the v-jun transfection did not result in malignant progression; instead, we made the unexpected …
-
Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
… diseases like obesity, metabolic syndrome, tumor invasion and metastasis, and coronary heart disease. Currently, there is no Food and Drug Administration approval for inactivating higher levels of PAI-1. Therefore, PAI-1 is considered an attractive drug target. Due to PAI-1’s different …
-
The role of tunneling nanotubes in mediating intercellular communication in cancer
Tumors are highly heterogeneous entities composed of malignant and stromal cells functioning together as an invasive unit. Effective and efficient intercellular crosstalk in the three-dimensional complex tumor microenvironment is essential for cancer progression. A relatively new mechanism of …
-
Hybrid Microfluidic Sensing Platforms for Cancer Cell Study: Recent Advances and Future Prospects
… develop novel organ-on chips to study cancerous tumor invasion and substitute animal testing. Furthermore, many efforts have been made by incorporating sensing instruments with these microfluidic systems to monitor cellular/organ activities continuously and quantitively evaluate their behaviour …
-
LKB1, CCL2, and Macrophages: A New Axis of Endometrial Cancer Progression
… in women with no adequate treatments for tumors that have progressed beyond the uterus. The serine-threonine kinase LKB1 has been identified as a potent suppressor of uterine cancer. Combined genetic, proteomic, and in vivo studies in genetically engineered mouse models show that loss of …
-
Mechanisms and consequences of regulating neurabin and spinophilin's interaction with the tumor suppressor protein p140CAP
… available. SRC terminal kinase (SRC) is a tumorigenic protein that is highly expressed in glioblastoma samples. SRC inhibitor kinase 1 (SRCIN1), also known as p140Cap is a negative regulator of SRC. Silencing SRCIN1 results in increased tumor invasion. Our lab has discovered two novel …
-
MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… collective motility, immune activation, and tumor invasion. We recently demonstrated that RAB5A, an endocytic small GTPase, induces tissue fluidification, promotes BC progression, and triggers an inflammatory gene response via cGAS/STING pathway and the acquisition of malignant traits. While …
-
Complications in Laparoscopy-Assisted Gastrectomy: Multivariate Analysis of 300 Consecutive Cases
… additional operative procedure, depth of tumor invasion and stage. Outcome data consisted of mortality, major morbidities, and postoperative hospital stay. The 300 patients were divided into 2 periods; 50 cases in the 1st period and 250 cases in the 2nd period. RESULTS: Postoperative …
-
MODELLING CELL POPULATION GROWTH
The growth of biological matter, e.g., tumor invasion, depends on various factors, mainly the tissue’s mechanical properties, implying elasticity, stiffness, or apparent viscosity. These properties are impacted by the characteristics of the tissue’s extracellular matrix and constituent cells, …
-
Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models
… influence of myriad cell types present in the tumor microenvironment, such as neurons, contribute to glioma progression. This dissertation represents a multi-pronged effort to unravel GBM heterogeneity by leveraging patient-derived GBM organoids (GBOs), a 3-dimensional model inspired by human …
-
Correlation of Cyclooxygenase-2 and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract
… role in cancer progression by affecting tumor cell proliferation, resistance to apoptosis, angiogenesis, and tumor invasion in several types of cancers. However, studies about COX-2 expression in transitional cell carcinoma of the upper urinary tract have been limited. In this study, the …
-
Expression of E-cadherin and HGF in Hypopharyngeal Cancer
… of epithelium, and also may be involved in tumor invasion. So we examined the role of the E-cadherin/HGF on invasion and metastasis of hypopharyngeal squamous cell carcinoma(SCC). MATERIALS AND METHOD: We performed immunohistochemical stains on 40 tissues of hypopharyngeal cancer patients …
-
Identification and imaging different lipid species within phase-separated model membranes by integration of TOF-SIMS and principal component analysis
… changes in glycosylation are correlated with tumor invasion and cancer metastasis, knowledge of glycan structures and locations on individual cells is required to determine their normal and disease-related functions. Here we combined PCA with matrix-enhanced SIMS (ME-SIMS), which is the …
-
Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. However, there is controversial data in the literature about CXCR2 expression in tumor cells and its role in the tumor microenvironment. We hypothesized that tumoral expression of CXCR2 and its ligands promote …
-
Βιολογική εξέλιξη των επιφανειακών όγκων της ουροδόχου κύστεως
… with primary, non invasive, transitional tumor of the urinary bladder, have been studied thoroughly. We tried to determine those biological factors of the tumor, who have, seriously influenced the evolution of the patients. The mean age of our patients was 59,3 years and the men were …
Page 1 of 2